Association of inflammation with raised serum IgA in ankylosing spondylitis.

abstract：OBJECTIVE:To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. METH...

journal_title：Annals of the rheumatic diseases

authors： Rasmussen A,Ice JA,Li H,Grundahl K,Kelly JA,Radfar L,Stone DU,Hefner KS,Anaya JM,Rohrer M,Gopalakrishnan R,Houston GD,Lewis DM,Chodosh J,Harley JB,Hughes P,Maier-Moore JS,Montgomery CG,Rhodus NL,Farris AD,Segal BM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I). METHODS:Arthritis patients from the DANBIO database were followed-up for cancer in the Danish Cancer Registry during 2000-2008. RESULTS:Hazard ratio for cancer overall was 1.02 (95% confidence inte...

journal_title：Annals of the rheumatic diseases

authors： Dreyer L,Mellemkjær L,Andersen AR,Bennett P,Poulsen UE,Juulsgaard Ellingsen T,Hansen TH,Jensen DV,Linde L,Lindegaard HM,Loft AG,Nordin H,Omerovic E,Rasmussen C,Schlemmer A,Tarp U,Hetland ML

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA). METHODS:A randomised, double-blind, placebo-controlled, dose-e...

journal_title：Annals of the rheumatic diseases

authors： Burmester GR,Feist E,Sleeman MA,Wang B,White B,Magrini F

更新日期：2011-09-01 00:00:00

abstract：:Sera from patients with rheumatoid arthritis (RA), patients with infectious mononucleosis (IM), and blood donors were tested by indirect immunofluorescence for the presence of antikeratin antibody (AKA), antibody to cytoskeletal intermediate filaments of prekeratin or vimentin type (AIFA) and antiperinuclear factor (A...

journal_title：Annals of the rheumatic diseases

authors： Kataaha PK,Mortazavi-Milani SM,Russell G,Holborow EJ

更新日期：1985-07-01 00:00:00

abstract：OBJECTIVES:To develop a preliminary composite psoriatic disease activity index (CPDAI) for psoriasis and psoriatic arthritis. METHODS:Five domains were assessed and specific instruments were employed for each domain to determine the extent of domain involvement and the effect of that involvement on quality of life/fun...

journal_title：Annals of the rheumatic diseases

authors： Mumtaz A,Gallagher P,Kirby B,Waxman R,Coates LC,Veale J D,Helliwell P,FitzGerald O

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in patients with active, refractory systemic lupus erythematosus (SLE). METHODS:Twelve patients received a median of two (range 1-4) 21-day cycles of i...

journal_title：Annals of the rheumatic diseases

authors： Alexander T,Sarfert R,Klotsche J,Kühl AA,Rubbert-Roth A,Lorenz HM,Rech J,Hoyer BF,Cheng Q,Waka A,Taddeo A,Wiesener M,Schett G,Burmester GR,Radbruch A,Hiepe F,Voll RE

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

journal_title：Annals of the rheumatic diseases

authors： Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To study the risk of a second malignant neoplasm (SMN) and mortality in patients with rheumatoid arthritis (RA) with a history of a primary cancer diagnosis and treated with biological disease-modifying antirheumatic drugs (bDMARD). METHODS:Among patients with RA (n=15 286) registered in the DANBIO Register ...

journal_title：Annals of the rheumatic diseases

authors： Dreyer L,Cordtz RL,Hansen IMJ,Kristensen LE,Hetland ML,Mellemkjaer L

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Soluble E-selectin (sE-selectin) is a marker of activation of vascular endothelium. OBJECTIVE:To examine serum levels of sE-selectin in a cohort of 85 patients with early rheumatoid arthritis (RA) followed up for five years. METHODS:sE-selectin levels were assessed annually using an enzyme linked immunosor...

journal_title：Annals of the rheumatic diseases

authors： Kuuliala A,Eberhardt K,Takala A,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of antithyroid antibodies and the presence of autoimmune thyroiditis among patients with primary Sjögren's syndrome. DESIGN:A case-control study. METHODS:53 consecutive patients with primary Sjögren's syndrome, 30 with rheumatoid arthritis, 12 with secondary Sjögren's syndrome ass...

journal_title：Annals of the rheumatic diseases

authors： Tunc R,Gonen MS,Acbay O,Hamuryudan V,Yazici H

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To investigate if the increased concentrations of stromelysin (MMP-3) found in the synovial fluid (SF) of patients with various arthritides reflect the concentrations in the circulation. METHODS:Using a double antibody ELISA, we have measured proMMP-3 concentrations in sera from these patient groups and in o...

journal_title：Annals of the rheumatic diseases

authors： Taylor DJ,Cheung NT,Dawes PT

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVES:To determine the probability of drug continuation in a large cohort of methotrexate treated rheumatoid arthritis (RA) patients, the reasons for discontinuation of methotrexate, the overall survival of the members of this cohort, and the causes of death in these patients. METHODS:Yearly follow up was conduct...

journal_title：Annals of the rheumatic diseases

authors： Alarcón GS,Tracy IC,Strand GM,Singh K,Macaluso M

更新日期：1995-09-01 00:00:00

abstract：:Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease. To date, no intervention is available that alters the underlying mechanism of inflammation in AS. Currently available conventional treatments are palliative at best, and often fail to control symptoms in the long term. Cu...

journal_title：Annals of the rheumatic diseases

authors： Dougados M,Dijkmans B,Khan M,Maksymowych W,van der Linden S,Brandt J

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence and clinical significance of carotid artery intima-media thickness (IMT) in patients with primary antiphospholipid syndrome (APS). METHODS:28 patients with primary APS with at least a five year follow up, and 28 healthy subjects, matched by age and sex, were included in the stud...

journal_title：Annals of the rheumatic diseases

authors： Medina G,Casaos D,Jara LJ,Vera-Lastra O,Fuentes M,Barile L,Salas M

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To formulate EULAR recommendations for the management of early arthritis. METHODS:In accordance with EULAR's "standardised operating procedures", the task force pursued an evidence based approach and an approach based on expert opinion. A steering group comprised of 14 rheumatologists representing 10 Europea...

journal_title：Annals of the rheumatic diseases

authors： Combe B,Landewe R,Lukas C,Bolosiu HD,Breedveld F,Dougados M,Emery P,Ferraccioli G,Hazes JM,Klareskog L,Machold K,Martin-Mola E,Nielsen H,Silman A,Smolen J,Yazici H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Qualitative differences in synovitis between the cartilage-pannus junction (CPJ) region and the adjoining suprapatellar pouch (SPP) have been reported in rheumatoid arthritis and the spondyloarthropathies. OBJECTIVE:To determine if the distribution of synovitis is the same in osteoarthritis (OA) using sensi...

journal_title：Annals of the rheumatic diseases

authors： Rhodes LA,Conaghan PG,Radjenovic A,Grainger AJ,Emery P,McGonagle D

更新日期：2005-09-01 00:00:00

abstract：:One hundred acute geriatric inpatients were assessed to investigate the prevalence of shoulder disorders; 21 had symptoms due to shoulder disease. Conditions included supraspinatus tendinitis (five), chronic rotator cuff rupture (seven), frozen shoulder (two), glenohumeral osteoarthritis (two), apatite related shoulde...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Hazleman BL

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVES:Development of non-Hodgkin's lymphoma (NHL) is the major adverse outcome of Sjögren's syndrome (SS) affecting both morbidity and mortality. Preliminary evidence suggested that, although not deregulated compared with sicca controls, miR200b-5p levels are decreased in the minor salivary glands (MSGs) of SS pat...

journal_title：Annals of the rheumatic diseases

authors： Kapsogeorgou EK,Papageorgiou A,Protogerou AD,Voulgarelis M,Tzioufas AG

更新日期：2018-08-01 00:00:00

abstract：:In this retrospective study of 57 patients with primary hyperparathyroidism who underwent parathyroidectomy, the overall incidence of chondrocalcinosis was 40%. Neither joint symptoms nor chondrocalcinosis regressed after the operation. In several patients the condition appeared to deteriorate both clinically and radi...

journal_title：Annals of the rheumatic diseases

authors： Glass JS,Grahame R

更新日期：1976-12-01 00:00:00

abstract：OBJECTIVE:To clarify the deleterious effects of Mayer's haematoxylin staining procedure which result in a decrease in, or complete loss of, the number of calcium pyrophosphate dihydrate (CPPD) crystals, and to determine the proper staining period for preserving the crystals in a histological paraffin section of articul...

journal_title：Annals of the rheumatic diseases

authors： Ohira T,Ishikawa K

更新日期：2001-01-01 00:00:00

abstract：:The viscosity of plasma (PV) was investigated in 27 outpatients with classical or definite rheumatoid arthritis (RA) according to the American Rheumatism Association (ARA) criteria. The measurements showed a significantly raised PV in patients with RA (p less than 10(-5)) compared with a control group. There was a pos...

journal_title：Annals of the rheumatic diseases

authors： Harreby M,Danneskiold-Samsøe B,Kjer J,Lauritzen M

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:To identify differentially expressed genes in peripheral blood mononuclear cells (PBMCs) from patients with ankylosing spondylitis (AS) compared with healthy individuals. METHODS:RNA was extracted from PBMCs collected from 18 patients with active disease and 18 gender-matched and age-matched controls. Expres...

journal_title：Annals of the rheumatic diseases

authors： Duan R,Leo P,Bradbury L,Brown MA,Thomas G

更新日期：2010-09-01 00:00:00

abstract：:Sixteen patients with classic rheumatoid arthritis (RA) complicated by severe vasculitis were studied and compared with a matched control group of 16 RA patients without vasculitis. Seven of the patients with vasculitis died within 4 to 120 months (median 32 months) after developing vasculitic symptoms. Gangrene of di...

journal_title：Annals of the rheumatic diseases

authors： Geirsson AJ,Sturfelt G,Truedsson L

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjögren syndrome. METHODS:Cryostat sections of labial salivary glands from 15 patients with primary Sjögren syndrome were examined by an indirect immunoperoxidase technique and monoclonal antibodies to a pa...

journal_title：Annals of the rheumatic diseases

authors： Aziz KE,McCluskey PJ,Wakefield D

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：:An 85 year old man with a longstanding history of non-tophaceous gout developed a single large tophus, unassociated with inflammation, on his paretic leg over a six week period following an acute hemiplegia. The rapidity of tophus formation, its localisation to the paretic limb, and the apparent blunting of the acute ...

journal_title：Annals of the rheumatic diseases

authors： Donegan CF,Berman P,Doherty M

更新日期：1993-04-01 00:00:00

abstract：:The early changes (five weeks) in the structure of newly synthesised and endogenous articular cartilage sulphated proteoglycans were studied in lapine IgG induced experimental immune synovitis. Rabbits with immune synovitis (IS-IgG) were compared with animals with a developed hypersensitivity to IgG (I-IgG) and with n...

journal_title：Annals of the rheumatic diseases

authors： Malemud CJ,Yoo JU,Goldberg VM,Kresina TF

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

更新日期：2004-02-01 00:00:00

abstract：:Eighty-one patients with 116 osteoarthritic knees were seen by the author at the University College Hospital (UCH), Ibadan in six years. Below the age of 50 the disease was significantly commoner among Nigerians than Caucasians; 39.5% of our patients were less than 50 years old, compared with 1.1% of Caucasians. In co...

journal_title：Annals of the rheumatic diseases

authors： Ebong WW

更新日期：1985-10-01 00:00:00

abstract：:T cells from patients with systemic lupus erythematosus exhibit a notable array of defects that probably contribute to the origin and development of the disease. Such abnormalities include an abnormal response to stimulation, aberrant expression of molecules that play key roles in intracellular signalling pathways, al...

journal_title：Annals of the rheumatic diseases

authors： Crispín JC,Kyttaris V,Juang YT,Tsokos GC

更新日期：2007-11-01 00:00:00