Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.

abstract：OBJECTIVES:Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is known yet about the mechanisms determining the double-edged role of eosinophils....

journal_title：Annals of the rheumatic diseases

authors： Andreev D,Liu M,Kachler K,Llerins Perez M,Kirchner P,Kölle J,Gießl A,Rauber S,Song R,Aust O,Grüneboom A,Kleyer A,Cañete JD,Ekici A,Ramming A,Finotto S,Schett G,Bozec A

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

journal_title：Annals of the rheumatic diseases

authors： Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Medical management of adults with osteoarthritis (OA) who require non-steroidal anti-inflammatory drugs (NSAIDs) must be decided after assessing prevalent gastrointestinal (GI) and cardiovascular (CV) risks in the individual patient. OBJECTIVE:To evaluate the GI and CV risk profile of patients with OA who r...

journal_title：Annals of the rheumatic diseases

authors： Lanas A,Tornero J,Zamorano JL

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/C...

journal_title：Annals of the rheumatic diseases

authors： Raghu H,Lepus CM,Wang Q,Wong HH,Lingampalli N,Oliviero F,Punzi L,Giori NJ,Goodman SB,Chu CR,Sokolove JB,Robinson WH

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Hyperplasia of synovial fibroblasts, infiltration with lymphocytes and tissue hypoxia are major characteristics of rheumatoid arthritis (RA). Extensive data support a key role for toll-like receptors (TLRs) in RA. Little is known regarding the impact of hypoxia on TLR-induced inflammation in RA. The aim of t...

journal_title：Annals of the rheumatic diseases

authors： Hu F,Mu R,Zhu J,Shi L,Li Y,Liu X,Shao W,Li G,Li M,Su Y,Cohen PL,Qiu X,Li Z

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy. CASE REPORTS:Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate. METHODS:Iliac crest biopsy samples were t...

journal_title：Annals of the rheumatic diseases

authors： Preston SJ,Diamond T,Scott A,Laurent MR

更新日期：1993-08-01 00:00:00

abstract：:Three aspects of polymorphonuclear leucocyte (PMN) function were studied in 19 patients with Behçet's syndrome (BS). By 2 different techniques directed motility was found to be increased. This increase was largely due to the subgroup of patients with ocular involvement. Counts of absolute numbers of cells migrating hi...

journal_title：Annals of the rheumatic diseases

authors： Fordham JN,Davies PG,Kirk A,Currey HL

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis OA in a 13 week, multicentre, randomised, double blind study. METHODS:After a 37 day washout period for nonsteroidal antiinflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg...

journal_title：Annals of the rheumatic diseases

authors： Tannenbaum H,Berenbaum F,Reginster JY,Zacher J,Robinson J,Poor G,Bliddal H,Uebelhart D,Adami S,Navarro F,Lee A,Moore A,Gimona A

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVES:To investigate the hypothesis that synovial fluid (SF) from patients with osteoarthritis (OA) may contain calcium phosphate crystals that are either too small, or too few in number to be identified by conventional light microscopy techniques. METHODS:Twelve SF from 11 patients with established knee OA, five...

journal_title：Annals of the rheumatic diseases

authors： Swan A,Chapman B,Heap P,Seward H,Dieppe P

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functio...

journal_title：Annals of the rheumatic diseases

authors： Bocelli-Tyndall C,Trella E,Frachet A,Zajac P,Pfaff D,Geurts J,Heiler S,Barbero A,Mumme M,Resink TJ,Schaeren S,Spagnoli GC,Tyndall A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of golimumab over 104 weeks in patients with active ankylosing spondylitis. METHODS:At baseline, patients with active ankylosing spondylitis (n=356) were randomly assigned (1:1.8:1.8) to subcutaneous injections of placebo (group 1), golimumab 50 mg (group 2) or golimumab 100...

journal_title：Annals of the rheumatic diseases

authors： Braun J,Deodhar A,Inman RD,van der Heijde D,Mack M,Xu S,Hsu B

更新日期：2012-05-01 00:00:00

abstract：:The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This artic...

journal_title：Annals of the rheumatic diseases

authors： Flossmann O,Bacon P,de Groot K,Jayne D,Rasmussen N,Seo P,Westman K,Luqmani R

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To assess risk of cartilage loss in the tibiofemoral joint in relation to baseline damage severity, and to analyse the association of nearby pathologic findings on the risk of subsequent cartilage loss. METHODS:The Multicenter Osteoarthritis Study is a longitudinal study of individuals with or at high risk for...

journal_title：Annals of the rheumatic diseases

authors： Roemer FW,Felson DT,Wang K,Crema MD,Neogi T,Zhang Y,Nevitt MC,Marra MD,Lewis CE,Torner J,Guermazi A,MOST study investigators.

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:Chondrocytic matrix metalloproteinases (MMPs) are believed to be important in osteoarthritic cartilage degradation. The cartilage lesion of osteoarthritis (OA) is focal and often progressive. During its development chondrocytes differentially up and down regulate production of mRNA for individual MMPs. This ...

journal_title：Annals of the rheumatic diseases

authors： Freemont AJ,Byers RJ,Taiwo YO,Hoyland JA

更新日期：1999-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is diagnosed based on phenotypic characteristics. The 2010 ACR/EULAR criteria were derived with the aim of classifying RA earlier in the disease course than the 1987 ACR criteria. When reviewing thus far published validation studies, it is clear that the 2010 criteria can be fulfilled earlier...

journal_title：Annals of the rheumatic diseases

authors： van der Helm-van Mil AH,Huizinga TW

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS:970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The pri...

journal_title：Annals of the rheumatic diseases

authors： Lohmander LS,McKeith D,Svensson O,Malmenäs M,Bolin L,Kalla A,Genti G,Szechinski J,Ramos-Remus C,STAR Multinational Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Pulmonary hypertension in systemic lupus erythematosus (SLE) is rare in the absence of parenchymal lung disease. We report such a case, which was complicated by the subsequent development of a left recurrent laryngeal nerve palsy, and in which there was a strong family history of SLE. ...

journal_title：Annals of the rheumatic diseases

authors： Aszkenasy OM,Clarke TJ,Hickling P,Marshall AJ

更新日期：1987-03-01 00:00:00

abstract：:A nutritional assessment of 50 patients with rheumatoid arthritis (RA) showed evidence of malnutrition in 13 (26%), while all 50 control subjects had normal nutritional status. Of the anthropometric measurements the body-mass index and triceps skinfold thickness values in men and women were significantly reduced in RA...

journal_title：Annals of the rheumatic diseases

authors： Helliwell M,Coombes EJ,Moody BJ,Batstone GF,Robertson JC

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Soluble E-selectin (sE-selectin) is a marker of activation of vascular endothelium. OBJECTIVE:To examine serum levels of sE-selectin in a cohort of 85 patients with early rheumatoid arthritis (RA) followed up for five years. METHODS:sE-selectin levels were assessed annually using an enzyme linked immunosor...

journal_title：Annals of the rheumatic diseases

authors： Kuuliala A,Eberhardt K,Takala A,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:To compare levels of disability of people with and without hip and knee arthroplasty in a random national sample. METHODS:In 1999 a screening questionnaire to classify people into groups of increasing probabilities of disability was sent to 417 500 people; response rate 86%. The study population was obtaine...

journal_title：Annals of the rheumatic diseases

authors： Boutron I,Poiraudeau S,Ravaud JF,Baron G,Revel M,Nizard R,Dougados M,Ravaud P

更新日期：2003-08-01 00:00:00

abstract：:Four patients with Neisseria meningitidis infection complicated by arthritis are described. Three patients had an acute polyarthritis which responded quickly to antimicrobial therapy. A fourth patient developed a prolonged arthritis which occurred after the initial infection had been successfully treated. Tenosynoviti...

journal_title：Annals of the rheumatic diseases

authors： Kidd BL,Hart HH,Grigor RR

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Vascular damage is a key pathological process in systemic sclerosis (SSc) and accounts for significant disease-related morbidity. To determine the clinical burden of severe digital vasculopathy (SDV), we have reviewed hospital-based treatment for this important complication of SSc in a large single centre co...

journal_title：Annals of the rheumatic diseases

authors： Nihtyanova SI,Brough GM,Black CM,Denton CP

更新日期：2008-01-01 00:00:00

abstract：:HLA A, B, and C antigens were studied in 25 patients with ankylosing hyperostosis. There was no evidence of an increased frequency of any antigen in association with the condition itself. However, a high frequency of several antigens was found, reflecting the predominance of Jewish patients in the series. ...

journal_title：Annals of the rheumatic diseases

authors： Perry JD,Wolf H,Festenstein H,Storey GO

更新日期：1979-02-01 00:00:00

abstract：:Animals were injected intra-articularly with antigen after prior immunization with that antigen in Freund's incomplete adjuvant in order to precipitate immune complexes in the surfaces of menisci, ligaments, and cartilage. On reimmunization with antigen in Freund's complete adjuvant 10 weeks later, generally an arthri...

journal_title：Annals of the rheumatic diseases

authors： Fox A,Glynn LE

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVES:To compare the effects of etanercept (ETN) 50 mg once weekly plus methotrexate (MTX) versus MTX alone on patient-reported outcomes (PROs) and the relationship between remission and PRO improvement. METHODS:In this double-blind, randomised clinical trial (COMET), PROs included: the Health Assessment Question...

journal_title：Annals of the rheumatic diseases

authors： Kekow J,Moots RJ,Emery P,Durez P,Koenig A,Singh A,Pedersen R,Robertson D,Freundlich B,Sato R

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Anti-citrullinated protein antibodies (ACPA) and anti-cyclic citrullinated peptide (anti-CCP) antibodies are a hallmark of rheumatoid arthritis and are believed to play a role in disease pathogenesis. These antibodies are typically detected in ELISA with citrullinated peptides (eg, CCP2) or proteins as antige...

journal_title：Annals of the rheumatic diseases

authors： Ioan-Facsinay A,el-Bannoudi H,Scherer HU,van der Woude D,Ménard HA,Lora M,Trouw LA,Huizinga TW,Toes RE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Antenatal and postnatal treatment with dexamethasone (DEX) may negatively affect the neuropsychological development in children. Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies may also be associated with learning disabilities in offspring. OBJECTIVE:To assess neuropsychological development in babies...

journal_title：Annals of the rheumatic diseases

authors： Brucato A,Astori MG,Cimaz R,Villa P,Li Destri M,Chimini L,Vaccari R,Muscarà M,Motta M,Tincani A,Neri F,Martinelli S

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to determine whether late apoptotic cell material directly induces autoantibodies characteristic of systemic lupus erythematosus (SLE) and to investigate the innate recognition pathways involved. METHODS:B6, B6.MyD88(-/-), B6.TLR7(-/-) and B6.TLR9(-/-) mice were subcutaneou...

journal_title：Annals of the rheumatic diseases

authors： Pan ZJ,Maier S,Schwarz K,Azbill J,Akira S,Uematsu S,Farris AD

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Bone erosion is a common manifestation of chronic tophaceous gout. OBJECTIVES:To investigate the effects of monosodium urate monohydrate (MSU) crystals on osteoblast viability and function. METHODS:The MTT assay and flow cytometry were used to assess osteoblast cell viability in the MC3T3-E1 and ST2 osteob...

journal_title：Annals of the rheumatic diseases

authors： Chhana A,Callon KE,Pool B,Naot D,Watson M,Gamble GD,McQueen FM,Cornish J,Dalbeth N

更新日期：2011-09-01 00:00:00

abstract：:Eighty-one patients with 116 osteoarthritic knees were seen by the author at the University College Hospital (UCH), Ibadan in six years. Below the age of 50 the disease was significantly commoner among Nigerians than Caucasians; 39.5% of our patients were less than 50 years old, compared with 1.1% of Caucasians. In co...

journal_title：Annals of the rheumatic diseases

authors： Ebong WW

更新日期：1985-10-01 00:00:00