Pneumococcal septic arthritis in rheumatoid arthritis.

abstract：OBJECTIVE:Although genome-wide association studies (GWAS) have identified approximately 100 loci for rheumatoid arthritis (RA), the disease mechanisms are not completely understood. We evaluated the pathogenesis of RA by focusing on rare coding variants. METHODS:The coding regions of 98 candidate genes identified by G...

journal_title：Annals of the rheumatic diseases

authors： Motegi T,Kochi Y,Matsuda K,Kubo M,Yamamoto K,Momozawa Y

更新日期：2019-08-01 00:00:00

abstract：:Leishmaniasis is an intracellular protozoan infection that can lead to cutaneous, mucocutaneous, visceral or systemic manifestations depending on the parasite species and virulence and on the host immune response. It is endemic in countries of Europe (Mediterranean basin), Asia, Africa, Central and South America, but ...

journal_title：Annals of the rheumatic diseases

authors： Bogdan C

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Fractalkine expressed on endothelial cells mediates activation and adhesion of leucocytes expressing its receptor, CX(3)CR1. Soluble fractalkine exhibits chemotactic activity for leucocytes expressing CX(3)CR1. OBJECTIVE:To determine the role of fractalkine and its receptor in systemic sclerosis (SSc) by as...

journal_title：Annals of the rheumatic diseases

authors： Hasegawa M,Sato S,Echigo T,Hamaguchi Y,Yasui M,Takehara K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:For our understanding of the pathogenesis of rheumatoid arthritis (RA), it is important to elucidate the mechanisms underlying early stages of synovitis. Here, synovial cytokine production was investigated in patients with very early arthritis. METHODS:Synovial biopsies were obtained from pat...

journal_title：Annals of the rheumatic diseases

authors： Yeo L,Adlard N,Biehl M,Juarez M,Smallie T,Snow M,Buckley CD,Raza K,Filer A,Scheel-Toellner D

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:Systemic sclerosis (SSc) is a rare disease requiring multicentre collaboration to reveal comprehensive details of disease-related causes for morbidity and mortality. METHODS:The European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) group initiated a database to prospectively ga...

journal_title：Annals of the rheumatic diseases

authors： Meier FM,Frommer KW,Dinser R,Walker UA,Czirjak L,Denton CP,Allanore Y,Distler O,Riemekasten G,Valentini G,Müller-Ladner U,EUSTAR Co-authors.

更新日期：2012-08-01 00:00:00

abstract：:In a multicentre study patients with rheumatoid arthritis judged by prevailing criteria to be suitable for synovectomy of the knee or metacarpophalangeal (MCP) joints were randomly allocated to one of two groups. One group had the operation, the other was observed without operation from a notional corresponding date. ...

journal_title：Annals of the rheumatic diseases

authors：

更新日期：1975-10-01 00:00:00

abstract：:Three patients, two with typical primary Sjögren's syndrome (SS) and the third with several features of SS, including abnormal sialography and reduced tear secretion, developed B cell non-Hodgkin's lymphoma (NHL) of parotid or lung, or both. Isoelectric focusing of concentrated urine specimens in agarose, followed by ...

journal_title：Annals of the rheumatic diseases

authors： Walters MT,Stevenson FK,Herbert A,Cawley MI,Smith JL

更新日期：1986-03-01 00:00:00

abstract：:(1) An epidemiological study of a rural African community has been carried out in the Western Transvaal. Altogether 801 respondents over 15 years old were examined; radiographs of the hands and feet were obtained in all these individuals. Serological tests for rheumatoid factor were carried out on 516 blood samples. (...

journal_title：Annals of the rheumatic diseases

authors： Beighton P,Solomon L,Valkenburg HA

更新日期：1975-04-01 00:00:00

abstract：OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...

journal_title：Annals of the rheumatic diseases

authors： Belcher C,Yaqub R,Fawthrop F,Bayliss M,Doherty M

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Precise diagnosis and follow up treatment of rheumatoid arthritis (RA) requires objective quantification, which is still lacking. For this purpose, radiological analyses are considered to be the most appropriate method. OBJECTIVE:To develop computer assisted quantification software that is particularly appl...

journal_title：Annals of the rheumatic diseases

authors： Wick M,Peloschek P,Bögl K,Graninger W,Smolen JS,Kainberger F

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:Reduced caveolin-1 levels in lung fibroblasts from patients with scleroderma and the lungs of bleomycin-treated mice promote collagen overexpression and lung fibrosis. This study was undertaken to determine whether caveolin-1 is deficient in leucocytes from bleomycin-treated mice and patients with scleroderm...

journal_title：Annals of the rheumatic diseases

authors： Tourkina E,Richard M,Oates J,Hofbauer A,Bonner M,Gööz P,Visconti R,Zhang J,Znoyko S,Hatfield CM,Silver RM,Hoffman S

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate changes in the levels of circulating cytokines with a focus on the Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS). METHODS:Plasma and serum samples of 34 pregnant patients, 19 with RA, ...

journal_title：Annals of the rheumatic diseases

authors： Østensen M,Förger F,Nelson JL,Schuhmacher A,Hebisch G,Villiger PM

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To elucidate factors involved in the arthritogenicity of bacterial cell walls. METHODS:For characterisation of an arthritogenic Eubacterium aerofaciens cell wall, peptidoglycan-polysaccharide (PG-PS) polymers were isolated by removing cell wall associated proteins (CWPs), PG and PS moieties were separated, a...

journal_title：Annals of the rheumatic diseases

authors： Zhang X,Rimpiläinen M,Simelyte E,Toivanen P

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) have an increased risk of certain solid cancers, in particular lung cancer, compared to the general population. Treatment with tumour necrosis factor (TNF) inhibitors (TNFi) may further enhance this risk. OBJECTIVES:To compare the risk of solid cancer in patients with...

journal_title：Annals of the rheumatic diseases

authors： Mercer LK,Lunt M,Low AL,Dixon WG,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium.

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. METHODS:322 Finnish patients with rheumatoid arthritis were typed for ...

journal_title：Annals of the rheumatic diseases

authors： Laivoranta-Nyman S,Möttönen T,Hermann R,Tuokko J,Luukkainen R,Hakala M,Hannonen P,Korpela M,Yli-Kerttula U,Toivanen A,Ilonen J,FIN-RACo Trial Group.

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:In patients with systemic sclerosis (scleroderma, SSc), impaired hand function greatly contributes to disability and reduced quality of life, and is insufficiently relieved by currently available therapies. Adipose tissue-derived stromal vascular fraction (SVF) is increasingly recognised as an easily accessi...

journal_title：Annals of the rheumatic diseases

authors： Granel B,Daumas A,Jouve E,Harlé JR,Nguyen PS,Chabannon C,Colavolpe N,Reynier JC,Truillet R,Mallet S,Baiada A,Casanova D,Giraudo L,Arnaud L,Veran J,Sabatier F,Magalon G

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Calprotectin is a major leucocyte protein, shown to correlate well with laboratory and clinical assessments in several inflammatory rheumatic diseases, and large concentrations of calprotectin have been found in synovial fluid from patients with rheumatoid arthritis (RA). The objective of the present study wa...

journal_title：Annals of the rheumatic diseases

authors： Hammer HB,Odegard S,Fagerhol MK,Landewé R,van der Heijde D,Uhlig T,Mowinckel P,Kvien TK

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population. METHOD:The screening questionnaire was based on signs and symptoms, previous diagnosis of OA and validated OA criteria. A random sample of telephone nu...

journal_title：Annals of the rheumatic diseases

authors： Roux CH,Saraux A,Mazieres B,Pouchot J,Morvan J,Fautrel B,Testa J,Fardellone P,Rat AC,Coste J,Guillemin F,Euller-Ziegler L,KHOALA Osteoarthritis Group.

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The heteropolymer technology was developed to remove pathogens from the circulation. OBJECTIVES:To evaluate the safety and tolerability of a single administration and to establish proof of principle for ETI-104 in normal healthy volunteers (NHV) and patients with systemic lupus erythematosus (SLE) METHODS: ...

journal_title：Annals of the rheumatic diseases

authors： Iking-Konert C,Stocks S,Weinsberg F,Engelbrecht R,Bleck E,Perniok A,Fischer-Betz R,Pincus S,Nardone L,Schneider M

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of the skin and the internal organs. Except for anticentromere, antitopoisomerase I and antipolymerase III antibodies, there are no reliable circulating markers predicting susceptibility and internal organ complications. This study h...

journal_title：Annals of the rheumatic diseases

authors： van Bon L,Cossu M,Loof A,Gohar F,Wittkowski H,Vonk M,Roth J,van den Berg W,van Heerde W,Broen JC,Radstake TR

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To compare individually tailored, based on trimestrial biological parameter monitoring, to fixed-schedule rituximab reinfusion for remission maintenance of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAVs). METHODS:Patients with newly diagnosed or relapsing granulomatosis with polyangii...

journal_title：Annals of the rheumatic diseases

authors： Charles P,Terrier B,Perrodeau É,Cohen P,Faguer S,Huart A,Hamidou M,Agard C,Bonnotte B,Samson M,Karras A,Jourde-Chiche N,Lifermann F,Gobert P,Hanrotel-Saliou C,Godmer P,Martin-Silva N,Pugnet G,Matignon M,Aumaitre O,

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE:To study associations betwee...

journal_title：Annals of the rheumatic diseases

authors： Claessen KM,Kloppenburg M,Kroon HM,Bijsterbosch J,Pereira AM,Romijn JA,van der Straaten T,Nelissen RG,Hofman A,Uitterlinden AG,Duijnisveld BJ,Lakenberg N,Beekman M,van Meurs JB,Slagboom PE,Biermasz NR,Meulenbelt I

更新日期：2014-02-01 00:00:00

abstract：:The prevalence of anticardiolipin antibodies was evaluated in 70 children with juvenile chronic arthritis (JCA), in 25 adult patients with rheumatoid arthritis, in 42 healthy children and in 40 adult controls. Thirty seven (53%) patients with JCA were positive for IgG or IgM anticardiolipin antibodies, or both, and 30...

journal_title：Annals of the rheumatic diseases

authors： Caporali R,Ravelli A,De Gennaro F,Neirotti G,Montecucco C,Martini A

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:Chondrocytic matrix metalloproteinases (MMPs) are believed to be important in osteoarthritic cartilage degradation. The cartilage lesion of osteoarthritis (OA) is focal and often progressive. During its development chondrocytes differentially up and down regulate production of mRNA for individual MMPs. This ...

journal_title：Annals of the rheumatic diseases

authors： Freemont AJ,Byers RJ,Taiwo YO,Hoyland JA

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor (TNF) treatment is clinically efficacious in patients with active ankylosing spondylitis (AS) and leads to improvement of spinal inflammation, as assessed by magnetic resonance imaging. It is unclear whether anti-TNF treatment affects chronic spinal changes in AS. OBJECTIVES:To a...

journal_title：Annals of the rheumatic diseases

authors： Baraliakos X,Listing J,Rudwaleit M,Brandt J,Sieper J,Braun J

更新日期：2005-10-01 00:00:00

abstract：:In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in response to alterations in the environment owing to mechanical injury and inflammation. These processes not only stimulate the production of enzymes that degrade the cartilage matrix but also inhibit repair. With the use of in vitro ...

journal_title：Annals of the rheumatic diseases

authors： Goldring MB,Otero M,Tsuchimochi K,Ijiri K,Li Y

更新日期：2008-12-01 00:00:00

abstract：:A controlled study compared 6 months' treatment of 60 patients with rheumatoid arthritis (RA). Half were randomly allocated to treatment with chloroquine 250 mg daily, the other half dapsone 100 mg daily (50 mg/day for the first 7 days) following a one-month run-in assessment period. All patients had active or progres...

journal_title：Annals of the rheumatic diseases

authors： Fowler PD,Shadforth MF,Crook PR,Lawton A

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：:The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9....

journal_title：Annals of the rheumatic diseases

authors： Tokunaga M,Ohuchi K,Yoshizawa S,Tsurufuji S,Rikimaru A,Wakamatsu E

更新日期：1981-10-01 00:00:00