Report on chloroquine and dapsone in the treatment of rheumatoid arthritis: a 6-month comparative study.

abstract：OBJECTIVE:To evaluate traditional and non-traditional risk factors for subclinical atherosclerosis in systemic lupus erythematosus (SLE). METHODS:A prospective cohort of 78 patients with SLE without overt atherosclerotic disease was studied. SLE clinical and laboratory parameters, disease activity and damage, treatmen...

journal_title：Annals of the rheumatic diseases

authors： Doria A,Shoenfeld Y,Wu R,Gambari PF,Puato M,Ghirardello A,Gilburd B,Corbanese S,Patnaik M,Zampieri S,Peter JB,Favaretto E,Iaccarino L,Sherer Y,Todesco S,Pauletto P

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVES:To investigate whether methotrexate or tumour necrosis factor inhibitors (TNFi) affect osteophyte formation in patients with psoriatic arthritis (PsA). METHODS:41 patients with PsA were examined for the presence of osteophytes and erosions at the metacarpophalangeal joints by high-resolution micro-CT imagin...

journal_title：Annals of the rheumatic diseases

authors： Finzel S,Kraus S,Schmidt S,Hueber A,Rech J,Engelke K,Englbrecht M,Schett G

更新日期：2013-07-01 00:00:00

abstract：:Purified peripheral blood polymorphonuclear leucocytes (PMNs) from patients with rheumatoid arthritis (RA) have been found to differ from purified PMNs from normal subjects in ways that are consistent with their prior activation. However, it is currently contentious whether activated PMNs really circulate in patients ...

journal_title：Annals of the rheumatic diseases

authors： McCarthy DA,Bernhagen J,Taylor MJ,Hamblin AS,James I,Thompson PW,Perry JD

更新日期：1992-01-01 00:00:00

abstract：:Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are a marker of bone formation. Because bone demineralisation is a common finding in patients with rheumatoid arthritis (RA)...

journal_title：Annals of the rheumatic diseases

authors： Pietschmann P,Machold KP,Wolosczuk W,Smolen JS

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVES:To compare levels of disability of people with and without hip and knee arthroplasty in a random national sample. METHODS:In 1999 a screening questionnaire to classify people into groups of increasing probabilities of disability was sent to 417 500 people; response rate 86%. The study population was obtaine...

journal_title：Annals of the rheumatic diseases

authors： Boutron I,Poiraudeau S,Ravaud JF,Baron G,Revel M,Nizard R,Dougados M,Ravaud P

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To study the association between the occurrence of peripheral arthritis and of acute anterior uveitis during the course of ankylosing spondylitis (AS). METHODS:Retrospective clinical follow up by both chart review and direct patient interview was performed on 271 individuals comprised of 222 local white and ...

journal_title：Annals of the rheumatic diseases

authors： Maksymowych WP,Chou CT,Russell AS

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:The 2010 ACR/EULAR classification criteria for rheumatoid arthritis (RA) were developed to improve the identification of individuals for studies of RA. We aimed to summarise the performance of the criteria based on the published literature. METHODS:We performed a systematic literature search to identify all...

journal_title：Annals of the rheumatic diseases

authors： Radner H,Neogi T,Smolen JS,Aletaha D

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS:In the population based, nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener's granulomatosis, 1969-95, was identified. Through linkage with...

journal_title：Annals of the rheumatic diseases

authors： Knight A,Askling J,Granath F,Sparen P,Ekbom A

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:The threshold for disease activity required to start antitumour necrosis factor (TNF) therapy has been arbitrarily set in patients with axial spondyloarthritis (axSpA) at Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4. How this relates to spinal inflammation is unknown. OBJECTIVE:To systema...

journal_title：Annals of the rheumatic diseases

authors： Kiltz U,Baraliakos X,Karakostas P,Igelmann M,Kalthoff L,Klink C,Krause D,Schmitz-Bortz E,Flörecke M,Bollow M,Braun J

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) blockade using infliximab, a chimeric anti-TNFalpha antibody, is an effective treatment for both psoriasis and psoriatic arthritis (PsA). OBJECTIVE:To analyse the early effects of infliximab treatment on serial skin and synovial tissue biopsy samples. METHODS:Twelve ...

journal_title：Annals of the rheumatic diseases

authors： Goedkoop AY,Kraan MC,Teunissen MB,Picavet DI,de Rie MA,Bos JD,Tak PP

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the nature of positional changes of humeroulnar (HU) and humeroradial (HR) joints in a cohort of 74 patients with seropositive and erosive rheumatoid arthritis (RA) followed up prospectively. METHODS:At the 15 year follow up standard anteroposterior and lateral radiographs of 148 elbow joints wer...

journal_title：Annals of the rheumatic diseases

authors： Lehtinen JT,Kaarela K,Kauppi MJ,Belt EA,Mäenpää H,Kuusela P,Lehto MU

更新日期：2001-08-01 00:00:00

abstract：:The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

journal_title：Annals of the rheumatic diseases

authors： Stevenson AC,Silcock SR,Scott JT

更新日期：1976-04-01 00:00:00

abstract：:A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. Magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient ...

journal_title：Annals of the rheumatic diseases

authors： Peh WC,Shek TW,Ip WY

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To elucidate the clinical importance of the anti-signal recognition particle (SRP) autoantibody in patients with myositis. METHODS:Retrospective systematic assessment of the clinical, laboratory and histological characteristics of 23 anti-SRP-positive patients from six European centres. Data were compared wi...

journal_title：Annals of the rheumatic diseases

authors： Hengstman GJ,ter Laak HJ,Vree Egberts WT,Lundberg IE,Moutsopoulos HM,Vencovsky J,Doria A,Mosca M,van Venrooij WJ,van Engelen BG

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of the skin and the internal organs. Except for anticentromere, antitopoisomerase I and antipolymerase III antibodies, there are no reliable circulating markers predicting susceptibility and internal organ complications. This study h...

journal_title：Annals of the rheumatic diseases

authors： van Bon L,Cossu M,Loof A,Gohar F,Wittkowski H,Vonk M,Roth J,van den Berg W,van Heerde W,Broen JC,Radstake TR

更新日期：2014-08-01 00:00:00

abstract：:Pulmonary hypertension in systemic lupus erythematosus (SLE) is rare in the absence of parenchymal lung disease. We report such a case, which was complicated by the subsequent development of a left recurrent laryngeal nerve palsy, and in which there was a strong family history of SLE. ...

journal_title：Annals of the rheumatic diseases

authors： Aszkenasy OM,Clarke TJ,Hickling P,Marshall AJ

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Despite the importance of timely management of patients with inflammatory arthritis (IA), delays exist in its diagnosis and treatment. OBJECTIVE:To perform a systematic literature review to identify strategies addressing these delays to inform an American College of Rheumatology (ACR)/European League Agains...

journal_title：Annals of the rheumatic diseases

authors： Villeneuve E,Nam JL,Bell MJ,Deighton CM,Felson DT,Hazes JM,McInnes IB,Silman AJ,Solomon DH,Thompson AE,White PH,Bykerk VP,Emery P

更新日期：2013-01-01 00:00:00

abstract：:The effect of two gold(I) compounds on stability of lysosomes in vitro was studied. Lysosomes from homogenates of rat kidney cortex were isolated by differential centrifugation. These lysosomes were incubated at 37 degrees C with widely varied concentrations of sodium aurothiomalate and sodium aurothiosulphate for 5, ...

journal_title：Annals of the rheumatic diseases

authors： Graabaek PM,Pedersen SM

更新日期：1988-06-01 00:00:00

abstract：:An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degener...

journal_title：Annals of the rheumatic diseases

authors： Gibson T,Burry HC,Poswillo D,Glass J

更新日期：1977-02-01 00:00:00

abstract：:Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associ...

journal_title：Annals of the rheumatic diseases

authors： Clegg DO,Zone JJ,Samuelson CO Jr,Ward JR

更新日期：1985-04-01 00:00:00

abstract：AIMS:The aim of this work was to assess the feasibility of using dynamic contrast enhanced (DCE) MRI of bone marrow oedema, to compare it with conventional marrow oedema scoring systems, and to determine the effects of anti-tumour necrosis factor (TNF)alpha therapy. METHODS:The wrist and metacarpophalangeal (MCP) join...

journal_title：Annals of the rheumatic diseases

authors： Hodgson R,Grainger A,O'Connor P,Barnes T,Connolly S,Moots R

更新日期：2008-02-01 00:00:00

abstract：:The clinical and laboratory data for an 8 year old girl with abdominal pain as a presenting manifestation of acute rheumatic fever are reported. An abdominal investigation with ultrasonography carried out at the same time showed free peritoneal fluid. These findings support the proposal that the abdominal pain classic...

journal_title：Annals of the rheumatic diseases

authors： Picard E,Gedalia A,Benmeir P,Zucker N,Barki Y

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that ankylosing spondylitis (AS) is a T helper cell type 2 polarised disease by quantifying the T cell cytokines interferon gamma (IFNgamma), interleukin 4 (IL4), tumour necrosis factor alpha (TNFalpha), and IL10 at the single cell level in patients with AS in comparison with healthy HL...

journal_title：Annals of the rheumatic diseases

authors： Rudwaleit M,Siegert S,Yin Z,Eick J,Thiel A,Radbruch A,Sieper J,Braun J

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically. OBJECTIVE:To compare evoked potential studies in APS patients and patients with multiple sclerosis with similar neurological disability. METHODS:30 APS patients with CNS manifestat...

journal_title：Annals of the rheumatic diseases

authors： Paran D,Chapman J,Korczyn AD,Elkayam O,Hilkevich O,Groozman GB,Levartovsky D,Litinsky I,Caspi D,Segev Y,Drory VE

更新日期：2006-04-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Roberts-Thomson PJ

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of tumour necrosis factor alpha (TNFalpha) blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX). METHODS:Participants were consecutive patients with RA and PsA who had undergone MTX treatment...

journal_title：Annals of the rheumatic diseases

authors： Seitz M,Reichenbach S,Möller B,Zwahlen M,Villiger PM,Dufour JF

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate quantitatively the mRNA expression levels of YKL-40, an established marker of rheumatoid and osteoarthritic cartilage degeneration in synovial fluid and serum, and a closely related molecule YKL-39, in articular chondrocytes. METHODS:cDNA array and online quantitative polymerase chain reaction...

journal_title：Annals of the rheumatic diseases

authors： Knorr T,Obermayr F,Bartnik E,Zien A,Aigner T

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:Over 50% of patients with rheumatoid arthritis (RA) harbour a variety of anti-modified protein antibodies (AMPA) against different post-translationally modified (PTM) proteins, including anti-carbamylated protein (anti-CarP) antibodies. At present, it is unknown how AMPA are generated and how autoreactive B ...

journal_title：Annals of the rheumatic diseases

authors： Dekkers JS,Verheul MK,Stoop JN,Liu B,Ioan-Facsinay A,van Veelen PA,de Ru AH,Janssen GMC,Hegen M,Rapecki S,Huizinga TWJ,Trouw LA,Toes REM

更新日期：2017-08-01 00:00:00

abstract：:T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through binding to its corresponding cell surface receptor. Three forms of the receptor are recognised based on IL2 binding affinity. The high affinity receptor is a heterotrimer composed of alpha, beta, and gamma(c)-polypeptide chain...

journal_title：Annals of the rheumatic diseases

authors： Morris JC,Waldmann TA

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:To assess the long-term effect of bariatric surgery on the incidence of gout and hyperuricaemia in participants of the Swedish Obese Subjects (SOS) study. METHODS:This report includes 1982 subjects who underwent bariatric surgery and 1999 obese controls from the SOS study, a prospective intervention trial d...

journal_title：Annals of the rheumatic diseases

authors： Maglio C,Peltonen M,Neovius M,Jacobson P,Jacobsson L,Rudin A,Carlsson LM

更新日期：2017-04-01 00:00:00