The degree of spinal inflammation is similar in patients with axial spondyloarthritis who report high or low levels of disease activity: a cohort study.

Abstract:

BACKGROUND:The threshold for disease activity required to start antitumour necrosis factor (TNF) therapy has been arbitrarily set in patients with axial spondyloarthritis (axSpA) at Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4. How this relates to spinal inflammation is unknown. OBJECTIVE:To systematically compare the clinical, laboratory and imaging data of patients with axSpA with respect to their BASDAI level. METHODS:A total of 100 consecutive patients with axSpA who had never been treated with TNF blockers were included. Laboratory parameters, spinal MRI and x-rays were quantified. Data were stratified according to BASDAI ≥ 4. RESULTS:44 patients were diagnosed as non-radiographic axSpA (nraxSpA) and 56 patients as ankylosing spondylitis (AS): median age 40.3 ± 10.4 years; 57% male, mean disease duration since diagnosis 6.4 ± 8.4 years, 88% HLA-B27+, mean modified Stokes Ankylosing Spondylitis Spinal Score 8.3 ± 16.4. 60% of patients had spinal inflammation by MRI. The stratification based on BASDAI ≥ 4 disclosed significant differences in most clinical parameters but not for inflammation: patients with nraxSpA and BASDAI < 4 versus ≥ 4 had 0.9 ± 1.4 and 0.5 ± 0.6 inflammatory lesions/patient, respectively (p=0.6), while patients with AS had 3.6 ± 3.7 and 2.7 ± 3.0 inflammatory lesions/patient, respectively (p=0.4). CONCLUSION:The burden of inflammation is quite comparable in patients with axSpA-regardless of disease activity. These data clearly challenge the concept of the recommended cut-off point of BASDAI ≥ 4.

journal_name

Ann Rheum Dis

authors

Kiltz U,Baraliakos X,Karakostas P,Igelmann M,Kalthoff L,Klink C,Krause D,Schmitz-Bortz E,Flörecke M,Bollow M,Braun J

doi

10.1136/annrheumdis-2011-200508

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1207-11

issue

7

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2011-200508

journal_volume

71

pub_type

杂志文章
  • Elaboration and validation of a questionnaire assessing patient expectations about management of knee osteoarthritis by their physicians: the Knee Osteoarthritis Expectations Questionnaire.

    abstract:OBJECTIVES:To develop a questionnaire assessing the expectations of patients regarding management of osteoarthritis (OA of the knee. METHODS:A detailed document reporting on a qualitative analysis of interviews of patients with knee OA was sent to experts and a Delphi procedure was adopted for item generation. Eighty ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2011-201206

    authors: Benhamou M,Boutron I,Dalichampt M,Baron G,Alami S,Rannou F,Ravaud P,Poiraudeau S

    更新日期:2013-04-01 00:00:00

  • Destructive arthritis associated with acne fulminans: a case report.

    abstract::Arthralgias have previously been reported in association with acne fulminans, but the following case in the first report of osseous lesions associated with this disease. The destructive bony lesion was rapid in onset but self-limited. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.39.4.403

    authors: Hunter LY,Hensinger RN

    更新日期:1980-08-01 00:00:00

  • Structural characteristics of articular cartilage proteoglycan in IgG induced experimental immune synovitis.

    abstract::The early changes (five weeks) in the structure of newly synthesised and endogenous articular cartilage sulphated proteoglycans were studied in lapine IgG induced experimental immune synovitis. Rabbits with immune synovitis (IS-IgG) were compared with animals with a developed hypersensitivity to IgG (I-IgG) and with n...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.46.7.520

    authors: Malemud CJ,Yoo JU,Goldberg VM,Kresina TF

    更新日期:1987-07-01 00:00:00

  • Clinical practice decision tree for the choice of the first disease modifying antirheumatic drug for very early rheumatoid arthritis: a 2004 proposal of the French Society of Rheumatology.

    abstract:OBJECTIVE:To elaborate a clinical practice decision tree for the choice of the first disease modifying antirheumatic drug (DMARD) for untreated rheumatoid arthritis of less than six months' duration. METHODS:Four steps were employed: (1) review of published reports on DMARD efficacy against rheumatoid arthritis; (2) i...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章

    doi:10.1136/ard.2005.035436

    authors: Le Loët X,Berthelot JM,Cantagrel A,Combe B,De Bandt M,Fautrel B,Flipo RM,Lioté F,Maillefert JF,Meyer O,Saraux A,Wendling D,Guillemin F

    更新日期:2006-01-01 00:00:00

  • Arthritis associated with hidradenitis suppurativa.

    abstract:OBJECTIVE:To review the presentation and clinical findings of arthritis associated with hidradenitis suppurativa. METHOD:Medical records from the rheumatology clinics of two major teaching hospitals were reviewed for arthritis and hidradenitis suppurativa. The nine patient records fulfilling these criteria were review...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.53.1.64

    authors: Bhalla R,Sequeira W

    更新日期:1994-01-01 00:00:00

  • Indomethacin serum concentrations in man. Effects of dosage, food, and antacid.

    abstract::In the use of anti-inflammatory compounds, sustained serum levels are thought to be related to drug efficacy. This study shows that frequent clinical administration of indomethacin can result in sustained serum levels of the drug and that food and antacid may have important modifying effects on serum indomethacin conc...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.35.4.333

    authors: Emori HW,Paulus H,Bluestone R,Champion GD,Pearson C

    更新日期:1976-08-01 00:00:00

  • Co-activation of synovial fibroblasts by laminin-111 and transforming growth factor-beta induces expression of matrix metalloproteinases 3 and 10 independently of nuclear factor-kappaB.

    abstract::We showed previously that the attachment of synovial fibroblasts to laminin (LM)-111 in the presence of transforming growth factor-beta induces significant expression of the matrix metalloproteinase (MMP)-3. Here we go on to investigate the regulation of additional MMPs and their specific tissue inhibitors of matrix p...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2007.073809

    authors: Warstat K,Pap T,Klein G,Gay S,Aicher WK

    更新日期:2008-04-01 00:00:00

  • Anticardiolipin antibodies in patients from Malaysia with systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is highly prevalent in Malaysia, which has a mixed population of Malays, Chinese, and Indians. A quantitative enzyme linked immunosorbent assay (ELISA) was used to determine anticardiolipin antibody (aCL) levels (total immunoglobulin, IgG, and IgM) in 200 patients with SLE (164 Chine...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.50.3.173

    authors: Jones HW,Ireland R,Senaldi G,Wang F,Khamashta M,Bellingham AJ,Veerapan K,Hughes GR,Vergani D

    更新日期:1991-03-01 00:00:00

  • Prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases: a systematic review and meta-analysis.

    abstract:OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2020-218946

    authors: Akiyama S,Hamdeh S,Micic D,Sakuraba A

    更新日期:2020-10-13 00:00:00

  • Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis.

    abstract:BACKGROUND:Tumour necrosis factor alpha (TNFalpha) may be an important mediator of insulin resistance. Infliximab is a chimeric monoclonal, high affinity antibody against the soluble and transmembrane TNFalpha, which can reduce markedly the biological activity of circulating and tissue TNFalpha and is used to treat var...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2004.026534

    authors: Kiortsis DN,Mavridis AK,Vasakos S,Nikas SN,Drosos AA

    更新日期:2005-05-01 00:00:00

  • T cell receptor expression in Sjögren's syndrome.

    abstract::T lymphocytes expressing the gamma/delta T cell receptor and B lymphocytes expressing CD5 are known to occur in expanded numbers in the peripheral blood of patients with primary Sjögren's syndrome. The cellular infiltrates for the surface phenotypic markers for alpha/beta and gamma/delta T cell receptors, CD4, CD8, CD...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.50.10.691

    authors: Zumla A,Mathur M,Stewart J,Wilkinson L,Isenberg D

    更新日期:1991-10-01 00:00:00

  • Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

    abstract:OBJECTIVES:The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early,...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-215051

    authors: Gohar F,McArdle A,Jones M,Callan N,Hernandez B,Kessel C,Miranda-Garcia M,Lavric M,Holzinger D,Pretzer C,Lainka E,Vastert SJ,de Roock S,FitzGerald O,Pennington SR,Foell D

    更新日期:2019-08-01 00:00:00

  • Double-blind comparison of efficacy and gastroduodenal safety of diclofenac/misoprostol, piroxicam, and naproxen in the treatment of osteoarthritis.

    abstract:OBJECTIVES:To compare the efficacy and gastroduodenal safety of a fixed-dose combination of diclofenac sodium 50 mg and misoprostol 200 micrograms twice daily with those of piroxicam 10 mg twice daily and naproxen 375 mg twice daily in patients with osteoarthritis. METHODS:A 4 week, randomised, double-blind, parallel-...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/ard.52.12.881

    authors: Melo Gomes JA,Roth SH,Zeeh J,Bruyn GA,Woods EM,Geis GS

    更新日期:1993-12-01 00:00:00

  • Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli.

    abstract::The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.34.4.326

    authors: Clarke AK,Vernon-Roberts B,Currey HL

    更新日期:1975-08-01 00:00:00

  • A prospective study of gout in New Zealand Maoris.

    abstract::Results are reported from the first prospective study of gout in New Zealand Maoris based on a sample of 388 males and 378 females. At baseline, high mean levels of serum uric acid (SUA) were found, 0.422 +/- 0.092 mmol/1 (7.05 +/- 1.54 mg/100 ml) in males and 0.350 +/- 0.091 mmol/1 (5.85 +/- 1.52 mg/100 ml) in female...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.37.5.466

    authors: Brauer GW,Prior IA

    更新日期:1978-10-01 00:00:00

  • Immunological and clinical follow up of hepatitis C virus associated cryoglobulinaemic vasculitis.

    abstract:OBJECTIVE:To study immunological markers and compare these markers with standard measures for the clinical and immunological follow up of vasculitis activity in hepatitis C virus (HCV) associated cryoglobulinaemic vasculitis (CV). METHODS:Serial serum samples from eight patients with newly diagnosed HCV associated CV ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.60.4.385

    authors: Lamprecht P,Moosig F,Gause A,Herlyn K,Csernok E,Hansen H,Gross WL

    更新日期:2001-04-01 00:00:00

  • Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis.

    abstract:BACKGROUND:The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease. OBJECTIVE:To combine hrMRI and cadaveric histological studie...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2005.050112

    authors: Tan AL,Toumi H,Benjamin M,Grainger AJ,Tanner SF,Emery P,McGonagle D

    更新日期:2006-10-01 00:00:00

  • Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogren's syndrome and association with disease activity and BAFF gene expression.

    abstract:OBJECTIVE:To determine the prevalence of upregulation of interferon (IFN) type I inducible genes, the so called 'IFN type I signature', in CD14 monocytes in 69 patients with primary Sjögren's syndrome (pSS) and 44 healthy controls (HC) and correlate it with disease manifestations and expression of B cell activating fac...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2012-201381

    authors: Brkic Z,Maria NI,van Helden-Meeuwsen CG,van de Merwe JP,van Daele PL,Dalm VA,Wildenberg ME,Beumer W,Drexhage HA,Versnel MA

    更新日期:2013-05-01 00:00:00

  • Arthritis in a human T lymphotropic virus type I (HTLV-I) carrier.

    abstract::The case is described of a 57 year old woman with polyarthritis fulfilling the 1987 revised criteria of the American Rheumatism Association for rheumatoid arthritis, accompanied by clinical carrier state infection of HTLV-I. Anti-HTLV-I IgM antibodies were detected by western blot analysis in her synovial fluid and se...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.49.9.718

    authors: Ijichi S,Matsuda T,Maruyama I,Izumihara T,Kojima K,Niimura T,Maruyama Y,Sonoda S,Yoshida A,Osame M

    更新日期:1990-09-01 00:00:00

  • Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab.

    abstract:OBJECTIVES:In a post-hoc analysis, we aimed to validate the Lupus Low Disease Activity State (LLDAS) definition as an endpoint in an systemic lupus erythematosus (SLE) Phase IIb randomised controlled trial (RCT) (MUSE [NCT01438489]) and then utilize LLDAS to discriminate between anifrolumab and placebo. METHODS:Patien...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/annrheumdis-2017-212504

    authors: Morand EF,Trasieva T,Berglind A,Illei GG,Tummala R

    更新日期:2018-05-01 00:00:00

  • Role of nitric oxide in the regulation of T cell functions.

    abstract::There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proli...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/ard.2006.058446

    authors: Niedbala W,Cai B,Liew FY

    更新日期:2006-11-01 00:00:00

  • Reducing arthritis fatigue impact: two-year randomised controlled trial of cognitive behavioural approaches by rheumatology teams (RAFT).

    abstract:OBJECTIVES:To see if a group course delivered by rheumatology teams using cognitive-behavioural approaches, plus usual care, reduced RA fatigue impact more than usual care alone. METHODS:Multicentre, 2-year randomised controlled trial in RA adults (fatigue severity>6/10, no recent major medication changes). RAFT (Redu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/annrheumdis-2018-214469

    authors: Hewlett S,Almeida C,Ambler N,Blair PS,Choy EH,Dures E,Hammond A,Hollingworth W,Kadir B,Kirwan JR,Plummer Z,Rooke C,Thorn J,Turner N,Pollock J,RAFT Study Group.

    更新日期:2019-04-01 00:00:00

  • Morphology of surface synoviocytes in situ at normal and raised joint pressure, studied by scanning electron microscopy.

    abstract::The synovial surface in rabbit knees was examined by scanning electron microscopy (SEM) to define normal surface contour, cell shape, and interstitial exposure. Comparison was made between specimens excised before immersion fixation (I), fixed in situ by vascular perfusion (V) before excision, or fixed in situ under a...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.47.3.232

    authors: McDonald JN,Levick JR

    更新日期:1988-03-01 00:00:00

  • IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population.

    abstract:PURPOSE:IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS:Four single-nucleotide polymorphisms (SNP), rs7517847, r...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1136/ard.2009.119420

    authors: Jiang Z,Yang P,Hou S,Du L,Xie L,Zhou H,Kijlstra A

    更新日期:2010-07-01 00:00:00

  • How long should we talk to patients? A study in doctor-patient communication.

    abstract::The 13 questions to which 173 rheumatic outpatients most frequently wished to know the answer were made the basis of a structured interview. Two lengths of interview were conducted in a controlled trial (short being of 2 minutes' duration, long ranging from 4 to 11 minutes). Sixty patients referred directly from their...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/ard.41.3.250

    authors: Wright V,Hopkins R,Burton K

    更新日期:1982-06-01 00:00:00

  • Measures of functional ability (disability) in arthritis in relation to impairment of range of joint movement.

    abstract::In the World Health Organisation's supplementary classification of the consequences of disease a distinction is made between impairments, such as are related to the site and nature of joint involvement, and any disabilities in everyday activities to which these may give rise. This paper considers the application of th...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.43.4.563

    authors: Badley EM,Wagstaff S,Wood PH

    更新日期:1984-08-01 00:00:00

  • Disease distribution of synovial fluid mast cells and cytophagocytic mononuclear cells in inflammatory arthritis.

    abstract::Three hundred and twenty-one synovial fluids from the knees of patients with six different inflammatory arthropathies have been examined for the presence of cytophagocytic monocytes (CPM) and mast cells. Both cell types were seen independently in many of the fluids examined but were found together only in those patien...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.44.5.312

    authors: Freemont AJ,Denton J

    更新日期:1985-05-01 00:00:00

  • Efficacy of etanercept in the treatment of acute, severe sciatica: a pilot study.

    abstract:OBJECTIVES:To explore the efficacy of a tumour necrosis factor alpha (TNFalpha) inhibitor (etanercept, Enbrel) in patients with severe sciatica. METHODS:A pilot study of etanercept was conducted in patients admitted to hospital for acute severe sciatica. Ten consecutive patients received three subcutaneous injections ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章

    doi:10.1136/ard.2003.016451

    authors: Genevay S,Stingelin S,Gabay C

    更新日期:2004-09-01 00:00:00

  • Bilateral rupture of the Achilles tendon in patients on steroid therapy.

    abstract::Three patients are presented who sustained bilateral rupture of the Achilles tendon while on systemic steroid therapy for chest disease; a fourth patient with polymyalgia rheumatica on steroids is also presented. This is further evidence that tendon rupture can be a direct complication of steroid treatment. The Englis...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.42.6.652

    authors: Haines JF

    更新日期:1983-12-01 00:00:00

  • Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort.

    abstract:OBJECTIVE:To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. METH...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2013-203845

    authors: Rasmussen A,Ice JA,Li H,Grundahl K,Kelly JA,Radfar L,Stone DU,Hefner KS,Anaya JM,Rohrer M,Gopalakrishnan R,Houston GD,Lewis DM,Chodosh J,Harley JB,Hughes P,Maier-Moore JS,Montgomery CG,Rhodus NL,Farris AD,Segal BM

    更新日期:2014-01-01 00:00:00