Anticardiolipin antibodies in patients from Malaysia with systemic lupus erythematosus.

abstract：:Current drug development programs produce high quality data on the efficacy of new drugs, substantial data on safety, but little data on actual applicability of the new product compared to standard of care. After successful registration and launch, such data require years to accumulate and often remain incomplete. Thi...

journal_title：Annals of the rheumatic diseases

authors： Boers M

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Development of non-Hodgkin's lymphoma (NHL) is the major adverse outcome of Sjögren's syndrome (SS) affecting both morbidity and mortality. Preliminary evidence suggested that, although not deregulated compared with sicca controls, miR200b-5p levels are decreased in the minor salivary glands (MSGs) of SS pat...

journal_title：Annals of the rheumatic diseases

authors： Kapsogeorgou EK,Papageorgiou A,Protogerou AD,Voulgarelis M,Tzioufas AG

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:To analyse the similarities and discrepancies between the official rheumatology specialty training programmes across Europe. METHODS:A steering committee defined the main aspects of training to be assessed. In 2013, the rheumatology official training programmes were reviewed for each of the European League ...

journal_title：Annals of the rheumatic diseases

authors： Sivera F,Ramiro S,Cikes N,Dougados M,Gossec L,Kvien TK,Lundberg IE,Mandl P,Moorthy A,Panchal S,da Silva JA,Bijlsma JW,Working Group on Training in Rheumatology across Europe.

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To investigate changes in the levels of circulating cytokines with a focus on the Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS). METHODS:Plasma and serum samples of 34 pregnant patients, 19 with RA, ...

journal_title：Annals of the rheumatic diseases

authors： Østensen M,Förger F,Nelson JL,Schuhmacher A,Hebisch G,Villiger PM

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To report the efficacy of conservative treatment with cervical traction and immobilisation with a Halo vest, in two consecutive rheumatoid arthritis patients with progressive cervical myelopathy caused by subaxial subluxation. METHODS:Description of neurological symptoms and signs and findings in plain radio...

journal_title：Annals of the rheumatic diseases

authors： Oostveen JC,van de Laar MA,Geelen JA,de Graaff R

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE. METHODS:The relationship between maternal age at littering and frequency of AE was analy...

journal_title：Annals of the rheumatic diseases

authors： Weinreich S,Hoebe B,Ivanyi P

更新日期：1995-09-01 00:00:00

abstract：:The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming growth factor beta (TGF-beta) was investigated in vitro and in vivo. In vitro TGF-beta (400 pmol/l) had no effect on basal proteoglycan degradation. Proteoglycan degradation induced by IL-1, ho...

journal_title：Annals of the rheumatic diseases

authors： van Beuningen HM,van der Kraan PM,Arntz OJ,van den Berg WB

更新日期：1993-03-01 00:00:00

abstract：:The microfocal x-ray unit, a new type of x-ray machine characterised by an extremely small x-ray source, enables great detail to be recorded in the projection radiographs owing to the high object magnification and resolution obtained with this system. Microfocal radiographic examinations were carried out on the wrists...

journal_title：Annals of the rheumatic diseases

authors： Buckland-Wright JC

更新日期：1984-04-01 00:00:00

abstract：:The first biological therapeutics in rheumatology are approaching patent expiration, encouraging development of 'follow-on' versions, known as 'biosimilars'. Biological agents range from simple replacement hormones to complex monoclonal antibodies and soluble receptors: large, intricate proteins with unique tertiary a...

journal_title：Annals of the rheumatic diseases

authors： Dörner T,Strand V,Castañeda-Hernández G,Ferraccioli G,Isaacs JD,Kvien TK,Martin-Mola E,Mittendorf T,Smolen JS,Burmester GR

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The 2010 ACR/EULAR classification criteria for rheumatoid arthritis (RA) were developed to improve the identification of individuals for studies of RA. We aimed to summarise the performance of the criteria based on the published literature. METHODS:We performed a systematic literature search to identify all...

journal_title：Annals of the rheumatic diseases

authors： Radner H,Neogi T,Smolen JS,Aletaha D

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated with gout flares. METHODS:We conducted an online case-crossover...

journal_title：Annals of the rheumatic diseases

authors： Yokose C,McCormick N,Chen C,Neogi T,Chaisson C,Terkeltaub R,Hunter DJ,Zhang Y,Choi H

更新日期：2019-11-01 00:00:00

abstract：:The early changes (five weeks) in the structure of newly synthesised and endogenous articular cartilage sulphated proteoglycans were studied in lapine IgG induced experimental immune synovitis. Rabbits with immune synovitis (IS-IgG) were compared with animals with a developed hypersensitivity to IgG (I-IgG) and with n...

journal_title：Annals of the rheumatic diseases

authors： Malemud CJ,Yoo JU,Goldberg VM,Kresina TF

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of golimumab over 104 weeks in patients with active ankylosing spondylitis. METHODS:At baseline, patients with active ankylosing spondylitis (n=356) were randomly assigned (1:1.8:1.8) to subcutaneous injections of placebo (group 1), golimumab 50 mg (group 2) or golimumab 100...

journal_title：Annals of the rheumatic diseases

authors： Braun J,Deodhar A,Inman RD,van der Heijde D,Mack M,Xu S,Hsu B

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:In systemic sclerosis (SSc), vascular involvement is characterised by vascular endothelial growth factor (VEGF)-A/VEGF receptor (VEGFR) system disturbances. Neuropilin-1 (NRP1), a receptor for both class-3 semaphorins (Sema3s) and VEGF-A, is required for optimal VEGF-A/VEGFR-2 signalling. Here, we investigat...

journal_title：Annals of the rheumatic diseases

authors： Romano E,Chora I,Manetti M,Mazzotta C,Rosa I,Bellando-Randone S,Blagojevic J,Soares R,Avouac J,Allanore Y,Ibba-Manneschi L,Matucci-Cerinic M,Guiducci S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine if neutrophils isolated from the blood and synovial fluid of patients with rheumatoid arthritis had patterns of receptor expression resembling those of blood neutrophils from controls which had been activated and primed in vitro. METHODS:Fluorescence activated cell sor...

journal_title：Annals of the rheumatic diseases

authors： Watson F,Robinson JJ,Phelan M,Bucknall RC,Edwards SW

更新日期：1993-05-01 00:00:00

abstract：:Ten patients (8 female, 2 male) with systemic lupus erythematosus (SLE) were entered into an open trial with the anabolic steroid 19-nortestosterone (19-nor). Their clinical condition did not improve, nor were significant changes observed in the majority of laboratory data. However, overall the platelet count rose, an...

journal_title：Annals of the rheumatic diseases

authors： Hazelton RA,McCruden AB,Sturrock RD,Stimson WH

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) may be an important mediator of insulin resistance. Infliximab is a chimeric monoclonal, high affinity antibody against the soluble and transmembrane TNFalpha, which can reduce markedly the biological activity of circulating and tissue TNFalpha and is used to treat var...

journal_title：Annals of the rheumatic diseases

authors： Kiortsis DN,Mavridis AK,Vasakos S,Nikas SN,Drosos AA

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To define the mechanisms whereby methotrexate (MTX) manifests its effects in patients with rheumatoid arthritis. METHODS:T and B cells from peripheral blood and rheumatoid synovial tissues, synovial adherent cells, and the human fibrosarcoma cell line HT1080 and its mutant (defective in an enzyme in the nucl...

journal_title：Annals of the rheumatic diseases

authors： Nakajima A,Hakoda M,Yamanaka H,Kamatani N,Kashiwazaki S

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVES:With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could d...

journal_title：Annals of the rheumatic diseases

authors： Lilleker JB,Hodgson R,Roberts M,Herholz K,Howard J,Hinz R,Chinoy H

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To characterise activation of the type I interferon (IFN) pathway in patients with systemic lupus erythematosus (SLE), dermatomyositis (DM), polymyositis (PM), rheumatoid arthritis (RA) and systemic scleroderma (SSc) and to evaluate the potential to develop a molecular diagnostic tool from the peripheral bloo...

journal_title：Annals of the rheumatic diseases

authors： Higgs BW,Liu Z,White B,Zhu W,White WI,Morehouse C,Brohawn P,Kiener PA,Richman L,Fiorentino D,Greenberg SA,Jallal B,Yao Y

更新日期：2011-11-01 00:00:00

abstract：:Purified peripheral blood polymorphonuclear leucocytes (PMNs) from patients with rheumatoid arthritis (RA) have been found to differ from purified PMNs from normal subjects in ways that are consistent with their prior activation. However, it is currently contentious whether activated PMNs really circulate in patients ...

journal_title：Annals of the rheumatic diseases

authors： McCarthy DA,Bernhagen J,Taylor MJ,Hamblin AS,James I,Thompson PW,Perry JD

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses t...

journal_title：Annals of the rheumatic diseases

authors： Malik MH,Jury F,Bayat A,Ollier WE,Kay PR

更新日期：2007-08-01 00:00:00

abstract：:Symptomatic osteonecrosis occurred in 8 out of 68 patients with systemic lupus erythematosus. Multiple joints were involved in 3 patients, and weight-bearing joints were most frequently affected. Osteonecrosis tended to occur early in the disease, and the patients had all received corticosteroids. Symptoms tended to o...

journal_title：Annals of the rheumatic diseases

authors： Griffiths ID,Maini RN,Scott JT

更新日期：1979-10-01 00:00:00

abstract：:Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients...

journal_title：Annals of the rheumatic diseases

authors： McInnes GT,Lawson DH,Jick H

更新日期：1981-06-01 00:00:00

abstract：:One hundred and two rural patients and 100 urban patients with rheumatoid arthritis and osteoarthrosis and 203 age and sex matched controls were visited in their homes to evaluate their problems, needs, and expectations. Although one would expect disability to affect the mobility of a person, it was found that rural p...

journal_title：Annals of the rheumatic diseases

authors： Cornelissen PG,Rasker JJ,Valkenburg HA

更新日期：1988-02-01 00:00:00

abstract：:There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proli...

journal_title：Annals of the rheumatic diseases

authors： Niedbala W,Cai B,Liew FY

更新日期：2006-11-01 00:00:00

abstract：:Previous work has suggested that prior poor reproductive outcome may be a risk factor in rheumatoid arthritis (RA). A case-control study of 195 women with RA and 462 control women from two different sources is presented here. No increase in rates of spontaneous abortion was seen in the women with RA; indeed a protecti...

journal_title：Annals of the rheumatic diseases

authors： Spector TD,Silman AJ

更新日期：1990-01-01 00:00:00

abstract：:The rapid introduction of immunotherapies for cancer-targeting immunological checkpoints has led to a new class of toxicities that appear to be of autoimmune and or autoinflammatory origin. These disorders are now referred to as immune-related adverse events (irAEs) and pose considerable challenges to patient care in ...

journal_title：Annals of the rheumatic diseases

authors： Calabrese L,Mariette X

更新日期：2018-02-01 00:00:00

abstract：:Erosions on the triquetrum and pisiform are frequent in early rheumatoid arthritis and occur characteristically at 3 sites. (a) A shallow erosion on the proximal medial triquetral "bare" area is related to synovial proliferation at the margin of the radiocarpal cavity, although compressive forces from an adjacent long...

journal_title：Annals of the rheumatic diseases

authors： Resnick D

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Oxidative stress in RA synovial tissue can cause DNA damage and suppress the DNA mismatch repair (MMR) system in cultured synoviocytes. This mechanism includes two enzyme complexes, hMutSalpha (hMSH2/hMSH6) and hMutSbeta (hMSH2/hMSH3). OBJECTIVE:To examine the expression and distribution of MMR enzymes in s...

journal_title：Annals of the rheumatic diseases

authors： Simelyte E,Boyle DL,Firestein GS

更新日期：2004-12-01 00:00:00