Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis.

abstract：OBJECTIVES:To clarify the effect of pressure on the expressions of proteoglycan core protein and metabolism related cytokines in a chondrocyte-like cell line, HCS-2/8. METHODS:HCS-2/8 cells were exposed to 1, 5, 10, or 50 MPa of hydrostatic pressure (HP) for two hours, and mRNA expressions of interleukin 6 (IL6) and t...

journal_title：Annals of the rheumatic diseases

authors： Takahashi K,Kubo T,Arai Y,Kitajima I,Takigawa M,Imanishi J,Hirasawa Y

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:The balance between interferon gamma (IFN gamma) and interleukin 4 (IL4) producing T cells (T1 and T2 cells) seems to be of importance in many (auto)immune disorders. In general, T1 cell activity is important in cellular immunity whereas T2 cell activity plays a part in humoral responses. T1 cell activity pr...

journal_title：Annals of the rheumatic diseases

authors： Verhoef CM,van Roon JA,Vianen ME,Bruijnzeel-Koomen CA,Lafeber FP,Bijlsma JW

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported. AIM:To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to l...

journal_title：Annals of the rheumatic diseases

authors： Hoberg M,Rudert M,Pap T,Klein G,Gay S,Aicher WK

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of incident myocardial infarction (MI), stroke and peripheral vascular disease (PVD) in individuals with systemic sclerosis (SSc) in a general population context. METHODS:We conducted a cohort study using a UK primary care database containing records from 1986 to 2011. SSc diagnoses, ou...

journal_title：Annals of the rheumatic diseases

authors： Man A,Zhu Y,Zhang Y,Dubreuil M,Rho YH,Peloquin C,Simms RW,Choi HK

更新日期：2013-07-01 00:00:00

abstract：:A case is reported of polytenosynovitis in a 31-year-old male during the course of a severe bacteraemic illness caused by Haemophilus influenzae type b. The clinical presentation was similar to tenosynovitis caused by bacterial or viral agents. As the management of the H. influenzae tenosynovitis would differ from tha...

journal_title：Annals of the rheumatic diseases

authors： Bansal S,Magnussen CR,Napodano RJ

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterised by synovitis and destruction of articular cartilage/bone. Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA. OBJECTIVES:To examine the effect of t...

journal_title：Annals of the rheumatic diseases

authors： Gao W,McGarry T,Orr C,McCormick J,Veale DJ,Fearon U

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To evaluate new classification criteria for peripheral spondyloarthritis (SpA) in patients with SpA with peripheral manifestations only. METHODS:In this Assessment of SpondyloArthritis international Society (ASAS) study, two prespecified sets of criteria were compared against the European Spondylarthropathy ...

journal_title：Annals of the rheumatic diseases

authors： Rudwaleit M,van der Heijde D,Landewé R,Akkoc N,Brandt J,Chou CT,Dougados M,Huang F,Gu J,Kirazli Y,Van den Bosch F,Olivieri I,Roussou E,Scarpato S,Sørensen IJ,Valle-Oñate R,Weber U,Wei J,Sieper J

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety between tocilizumab added to methotrexate and tocilizumab switched from methotrexate in patients with active rheumatoid arthritis (RA). METHODS:This is a 2-year randomised, controlled study. RA patients with moderate or high disease activity despite methotrexate were random...

journal_title：Annals of the rheumatic diseases

authors： Kaneko Y,Atsumi T,Tanaka Y,Inoo M,Kobayashi-Haraoka H,Amano K,Miyata M,Murakawa Y,Yasuoka H,Hirata S,Nagasawa H,Tanaka E,Miyasaka N,Yamanaka H,Yamamoto K,Takeuchi T

更新日期：2016-11-01 00:00:00

abstract：:Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Baeten D,Ulfgren AK,McInnes IB,Fitzgerald O,Bresnihan B,Tak PP,Veale D,OMERACT synovial special interests group.

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To assess the safety and effectiveness of imatinib mesylate in the treatment of diffuse cutaneous systemic sclerosis (dcSSc). METHODS:In this phase IIa, open-label, single-arm clinical trial, 30 patients with dcSSc were treated with imatinib 400 mg daily. Patients were monitored monthly for safety assessment...

journal_title：Annals of the rheumatic diseases

authors： Spiera RF,Gordon JK,Mersten JN,Magro CM,Mehta M,Wildman HF,Kloiber S,Kirou KA,Lyman S,Crow MK

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

journal_title：Annals of the rheumatic diseases

authors： Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

更新日期：2015-06-01 00:00:00

abstract：:We report two cases of osteomyelitis secondary to staphylococcal septicaemia, presenting with large sterile effusions in adjacent joints. In both cases the clinical features were suggestive of septic arthritis. Multiple joints were involved in each patient. Initial radiographs showed no abnormalities. ...

journal_title：Annals of the rheumatic diseases

authors： Platt PN,Griffiths ID

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:Previously an upregulation of E-cadherin and its associated molecules alpha-catenin, beta-catenin and plakoglobin has been demonstrated in clinically overt inflammatory bowel disease (IBD). The aim of this study was to investigate the expression of the E-cadherin/catenin complex in subclinically inflamed bowe...

journal_title：Annals of the rheumatic diseases

authors： Demetter P,Baeten D,De Keyser F,De Vos M,Van Damme N,Verbruggen G,Vermeulen S,Mareel M,Elewaut D,Mielants H,Veys EM,Cuvelier CA

更新日期：2000-03-01 00:00:00

abstract：:A family with features of the mucocutaneous ocular syndrome is described. A 4-generation study reveals that the condition has been inherited as an autosomal dominant trait with variable expressivity. Psychiatric symptoms and myalgia have been prominent features peculiar to our patients. ...

journal_title：Annals of the rheumatic diseases

authors： Berman L,Trappler B,Jenkins T

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:Based upon findings in juvenile idiopathic arthritis, the genetic contribution of the VTCN1 region to rheumatoid arthritis (RA) susceptibility and anticitrullinated protein antibody (ACPA) status was investigated. VTCN1 is known to play a pivotal role in regulation of the immune system and, in soluble form, h...

journal_title：Annals of the rheumatic diseases

authors： Daha NA,Lie BA,Trouw LA,Stoeken G,Schonkeren JJ,Ding B,Kvien TK,Schilham MW,Padyukov L,Huizinga TW,Toes R

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To investigate the incidence of new cancer diagnoses in a community sample of patients with polymyalgia rheumatica (PMR). METHODS:All incident cases of PMR in the UK General Practice Research Database (GPRD) (1987-99), without pre-existing cancer or vascular disease and treated with corticosteroids (n=2877) ...

journal_title：Annals of the rheumatic diseases

authors： Muller S,Hider SL,Belcher J,Helliwell T,Mallen CD

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:The impact of immunosuppression on postoperative outcomes has primarily been studied in patients undergoing joint replacement surgery. We aimed to evaluate the impact of biologics and glucocorticoids on outcomes after other major surgeries. METHODS:This retrospective cohort study used Medicare data 2006-201...

journal_title：Annals of the rheumatic diseases

authors： George MD,Baker JF,Winthrop KL,Goldstein SD,Alemao E,Chen L,Wu Q,Xie F,Curtis JR

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:The Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire is a recently developed patient-reported outcome measure (PROM) of disease impact in psoriatic arthritis (PsA). We set out to assess the validity in an independent cohort of patients, estimate the minimally important difference for improvement a...

journal_title：Annals of the rheumatic diseases

authors： Holland R,Tillett W,Korendowych E,Cavill C,Waldron N,Brooke M,McHugh NJ

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There is an urgent need for robust data on the trajectories and outcomes of pregnancies in women with inflammatory rheumatic diseases (IRD). In particular when rare outcomes or rare diseases are to be investigated, collaborative approaches are required. However, joint data analyses are often li...

journal_title：Annals of the rheumatic diseases

authors： Meissner Y,Fischer-Betz R,Andreoli L,Costedoat-Chalumeau N,De Cock D,Dolhain RJEM,Forger F,Goll D,Molto A,Nelson-Piercy C,Özdemir R,Raio L,Rodríguez-García SC,Sciascia S,Wallenius M,Zbinden A,Zink A,Strangfeld A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Poor adherence to treatment is difficult to diagnose accurately. Hydroxychloroquine (HCQ) has a long elimination half-life and its concentration in whole blood can be measured easily. OBJECTIVE:To evaluate the utility of a very low blood HCQ concentration as a marker of poor compliance in patients with syst...

journal_title：Annals of the rheumatic diseases

authors： Costedoat-Chalumeau N,Amoura Z,Hulot JS,Aymard G,Leroux G,Marra D,Lechat P,Piette JC

更新日期：2007-06-01 00:00:00

abstract：:The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of ea...

journal_title：Annals of the rheumatic diseases

authors： Garrett R,Manthey B,Vernon-Roberts B,Brooks PM

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Entheseal fibrocartilage (EF) derangement is hypothesised to be pivotal to the pathogenesis of spondyloarthritis. Ultrasound is useful for visualisation of the enthesis but its role in EF visualisation is uncertain. This work aimed to demonstrate face and content validity of ultrasound for EF visualisation b...

journal_title：Annals of the rheumatic diseases

authors： Aydin SZ,Bas E,Basci O,Filippucci E,Wakefield RJ,Celikel C,Karahan M,Atagunduz P,Benjamin M,Direskeneli H,McGonagle D

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses t...

journal_title：Annals of the rheumatic diseases

authors： Malik MH,Jury F,Bayat A,Ollier WE,Kay PR

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:To describe presentation and outcome of patients with scleroderma renal crisis (SRC). METHODS:SRC was defined as rapidly progressive oliguric renal insufficiency and/or rapidly progressive arterial hypertension occurring during the course of systemic sclerosis (SSc). Chronic dialysis-free survival was analy...

journal_title：Annals of the rheumatic diseases

authors： Teixeira L,Mouthon L,Mahr A,Berezné A,Agard C,Mehrenberger M,Noël LH,Trolliet P,Frances C,Cabane J,Guillevin L,Group Français de Recherche sur le Sclérodermie (GFRS).

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The aim of this report is to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) equivalence as well as similar efficacy, safety and immunogenicity between GP2013, a biosimilar rituximab, and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA) with inadequate response or intolerance to...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Cohen SB,Tony HP,Scheinberg M,Kivitz A,Balanescu A,Gomez-Reino J,Cen L,Zhu P,Shisha T

更新日期：2017-09-01 00:00:00

abstract：:The prosthetic knee joint of a 64 year old woman with severe rheumatoid arthritis was found to be infected with Listeria monocytogenes. After treatment with intravenous antibiotics, symptoms gradually resolved. She subsequently received prolonged treatment with oral co-trimoxazole and 18 months later remained well. ...

journal_title：Annals of the rheumatic diseases

authors： Booth LV,Walters MT,Tuck AC,Luqmani RA,Cawley MI

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:PATIENTS with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. OBJECTIVES:To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. METHODS: STUDY DESIGN:international, cross-sectional. PATIENTS:consecutiv...

journal_title：Annals of the rheumatic diseases

authors： Dougados M,Soubrier M,Antunez A,Balint P,Balsa A,Buch MH,Casado G,Detert J,El-Zorkany B,Emery P,Hajjaj-Hassouni N,Harigai M,Luo SF,Kurucz R,Maciel G,Mola EM,Montecucco CM,McInnes I,Radner H,Smolen JS,Song YW,Von

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. METHODS:TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical c...

journal_title：Annals of the rheumatic diseases

authors： Pettipher C,Benitha R

更新日期：2020-02-01 00:00:00

abstract：:Only a minority (7/35, 20%) of synovial fluids from patients with rheumatoid arthritis (RA) and none from patients with other arthritides stimulated the oxidative response of polymorphonuclear leucocytes (PMNs). Superoxide anion generation was measured by superoxide dismutase inhibitable reduction of cytochrome c. The...

journal_title：Annals of the rheumatic diseases

authors： Dularay B,Badesha JS,Dieppe PA,Elson CJ

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To determine whether abnormalities in the function of the autonomic nervous system are associated with oral and ocular dryness in rheumatoid arthritis. METHODS:Pupillography was done using an infrared light reflection method (IRIS) to measure both parasympathetic function (constriction latency and the latenc...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van der Heijde GL,Breedveld FC,Markusse HM

更新日期：1996-09-01 00:00:00