Interaction of polymorphonuclear leucocytes with patellar cartilage of immobilised arthritic joints: a scanning electron microscopic study.

abstract：INTRODUCTION:Endoplasmic reticulum aminopeptidase-1 (ERAP1) protein is highly polymorphic with numerous missense amino acid variants. We sought to determine the naturally occurring ERAP1 protein allotypes and their contribution to Behçet's disease. METHODS:Genotypes of all reported missense ERAP1 gene variants with 10...

journal_title：Annals of the rheumatic diseases

authors： Takeuchi M,Ombrello MJ,Kirino Y,Erer B,Tugal-Tutkun I,Seyahi E,Özyazgan Y,Watts NR,Gül A,Kastner DL,Remmers EF

更新日期：2016-12-01 00:00:00

abstract：:Serum samples were obtained from patients with polymyalgia rheumatica (PMR: n = 10) or giant cell arteritis (GCA; n = 7), or both. Samples were taken either before treatment or within one week of starting prednisolone. Immune complexes (IC) were concentrated by polyethylene glycol (PEG) precipitation then purified wit...

journal_title：Annals of the rheumatic diseases

authors： Smith AJ,Kyle V,Cawston TE,Hazleman BL

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

journal_title：Annals of the rheumatic diseases

authors： Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). OBJECTIVE:To investigate whether the recognition of citrullinated epitopes changes during disease onset or progression, by studying the fine specificity of ACPA in serum samples coll...

journal_title：Annals of the rheumatic diseases

authors： van der Woude D,Rantapää-Dahlqvist S,Ioan-Facsinay A,Onnekink C,Schwarte CM,Verpoort KN,Drijfhout JW,Huizinga TW,Toes RE,Pruijn GJ

更新日期：2010-08-01 00:00:00

abstract：:A novel explanation for the natural history of joint destruction in the early phase of ankylosing spondylitis is proposed on the basis of the clinical history, x-ray appearance, operative findings, and histopathology of a young patient believed to be suffering from the peripheral form of this disease. ...

journal_title：Annals of the rheumatic diseases

authors： Pasion EG,Goodfellow JW

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND AND AIM:Striving for harmonisation of specialty training and excellence of care in rheumatology, the European League Against Rheumatism (EULAR) established a task force to develop points to consider (PtCs) for the assessment of competences during rheumatology specialty training. METHODS:A systematic literat...

journal_title：Annals of the rheumatic diseases

authors： Sivera F,Alunno A,Najm A,Avcin T,Baraliakos X,Bijlsma JW,Badreh S,Burmester G,Cikes N,Da Silva JA,Damjanov N,Dougados M,Dudler J,Edwards CJ,Iagnocco A,Lioté F,Nikiphorou E,van Onna M,Stones SR,Vassilopoulos D,Hain

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a need to revise the instrument. The previous version of BVAS has been revised, according to usage and reviewed by an exper...

journal_title：Annals of the rheumatic diseases

authors： Mukhtyar C,Lee R,Brown D,Carruthers D,Dasgupta B,Dubey S,Flossmann O,Hall C,Hollywood J,Jayne D,Jones R,Lanyon P,Muir A,Scott D,Young L,Luqmani RA

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease with limited reliable diagnostic biomarkers. We investigated whether gene methylation could meet sensitivity and specificity criteria for a robust biomarker. METHODS:IFI44L promoter methylation was examined using DNA samples from a disc...

journal_title：Annals of the rheumatic diseases

authors： Zhao M,Zhou Y,Zhu B,Wan M,Jiang T,Tan Q,Liu Y,Jiang J,Luo S,Tan Y,Wu H,Renauer P,Del Mar Ayala Gutiérrez M,Castillo Palma MJ,Ortega Castro R,Fernández-Roldán C,Raya E,Faria R,Carvalho C,Alarcón-Riquelme ME,Xiang Z

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Studies in rheumatoid arthritis (RA), osteoarthritis (OA) and mice with arthritis demonstrated tyrosine hydroxylase-positive (TH(+)) cells in arthritic synovium and parallel loss of sympathetic nerve fibres. The exact function of TH(+) cells and mode of TH induction are not known. METHODS:Synovial cells of ...

journal_title：Annals of the rheumatic diseases

authors： Jenei-Lanzl Z,Capellino S,Kees F,Fleck M,Lowin T,Straub RH

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the influences of radiographic severity, quadriceps strength, knee pain, age, and gender on functional ability in patients with osteoarthritis of the knee. METHODS:Equal numbers of knee pain positive and negative respondents to a survey of registrants aged more than 55 years at a general practic...

journal_title：Annals of the rheumatic diseases

authors： McAlindon TE,Cooper C,Kirwan JR,Dieppe PA

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS:970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The pri...

journal_title：Annals of the rheumatic diseases

authors： Lohmander LS,McKeith D,Svensson O,Malmenäs M,Bolin L,Kalla A,Genti G,Szechinski J,Ramos-Remus C,STAR Multinational Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Antibiotic treatment of all disease manifestations after infection with Borrelia sensu lato spp aims at resolving the presenting disease manifestation and preventing late stage disease. The goals are resolution of the preventing manifestation and prevention of the spread of bacteria to prevent late disease like arthri...

journal_title：Annals of the rheumatic diseases

authors： Dinser R,Jendro MC,Schnarr S,Zeidler H

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To determine the serum levels of nucleosome in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc. METHODS:Serum nucleosome levels in 91 patients with SSc were examined by ELISA. The expression of Toll-like receptor (TLR) 9 in T and B cells was quantified by flow cy...

journal_title：Annals of the rheumatic diseases

authors： Yoshizaki A,Taniguchi T,Saigusa R,Fukasawa T,Ebata S,Numajiri H,Nakamura K,Yamashita T,Takahashi T,Toyama T,Asano Y,Tedder TF,Sato S

更新日期：2016-10-01 00:00:00

abstract：:The prevalence of anticardiolipin antibodies was evaluated in 70 children with juvenile chronic arthritis (JCA), in 25 adult patients with rheumatoid arthritis, in 42 healthy children and in 40 adult controls. Thirty seven (53%) patients with JCA were positive for IgG or IgM anticardiolipin antibodies, or both, and 30...

journal_title：Annals of the rheumatic diseases

authors： Caporali R,Ravelli A,De Gennaro F,Neirotti G,Montecucco C,Martini A

更新日期：1991-09-01 00:00:00

abstract：:Thirty patients with classical or definite rheumatoid disease (RD) with foot pain and radiologically demonstrated erosions were studied electrodiagnostically to ascertain the frequency of the tarsal tunnel syndrome and peripheral neuropathy. Four patients (13.3%) had evidence of the tarsal tunnel syndrome. The electri...

journal_title：Annals of the rheumatic diseases

authors： McGuigan L,Burke D,Fleming A

更新日期：1983-04-01 00:00:00

abstract：:Septic arthritis is associated with a definite morbidity which may be related to a delay in diagnosis and hence treatment. The cases of three patients with rheumatoid arthritis and chronic chest disease where the joint sepsis was not the predominant feature are presented. The responsible organism was Streptococcus pne...

journal_title：Annals of the rheumatic diseases

authors： Morley PK,Hull RG,Hall MA

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To characterise activation of the type I interferon (IFN) pathway in patients with systemic lupus erythematosus (SLE), dermatomyositis (DM), polymyositis (PM), rheumatoid arthritis (RA) and systemic scleroderma (SSc) and to evaluate the potential to develop a molecular diagnostic tool from the peripheral bloo...

journal_title：Annals of the rheumatic diseases

authors： Higgs BW,Liu Z,White B,Zhu W,White WI,Morehouse C,Brohawn P,Kiener PA,Richman L,Fiorentino D,Greenberg SA,Jallal B,Yao Y

更新日期：2011-11-01 00:00:00

abstract：:Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial ...

journal_title：Annals of the rheumatic diseases

authors： Rudge SR,Perrett D,Swannell AJ

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVES:To study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed. METHODS:We examined whether symptomatic (≥1 joint(s) with radio...

journal_title：Annals of the rheumatic diseases

authors： Haugen IK,Ramachandran VS,Misra D,Neogi T,Niu J,Yang T,Zhang Y,Felson DT

更新日期：2015-01-01 00:00:00

abstract：:Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are a marker of bone formation. Because bone demineralisation is a common finding in patients with rheumatoid arthritis (RA)...

journal_title：Annals of the rheumatic diseases

authors： Pietschmann P,Machold KP,Wolosczuk W,Smolen JS

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well established, and accounts for an estimated 30% of the genetic component in RA. The MHC class II transactivator gene (MHC2TA) on chromosome 16p13 has re...

journal_title：Annals of the rheumatic diseases

authors： Bronson PG,Criswell LA,Barcellos LF

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Rice bodies can occur in the joints in many rheumatic conditions, but they are most common in rheumatoid arthritis. They are generally believed to occur rarely in patients with osteoarthritis, but one study reported rice bodies with apatite crystals. OBJECTIVE:To report on a series of joint fluids with rice...

journal_title：Annals of the rheumatic diseases

authors： Li-Yu J,Clayburne GM,Sieck MS,Walker SE,Athreya BH,DeHoratius RJ,Schumacher HR Jr

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To confirm and extend the immunopathological evidence of effects of infliximab on the synovium in active spondyloarthropathy. METHODS:Synovial biopsies obtained in patients with spondyloarthropathy at baseline and week 12 were stained and scored by two independent observers. Two study populations were evalua...

journal_title：Annals of the rheumatic diseases

authors： Kruithof E,Baeten D,Van den Bosch F,Mielants H,Veys EM,De Keyser F

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the risk of septic arthritis (SA) in patients with rheumatoid arthritis (RA) treated with anti-tumour necrosis factor (TNF) therapy. METHODS:Using data from the British Society for Rheumatology Biologics Register, a prospective observational study, the authors compared the risk of SA between 11 ...

journal_title：Annals of the rheumatic diseases

authors： Galloway JB,Hyrich KL,Mercer LK,Dixon WG,Ustianowski AP,Helbert M,Watson KD,Lunt M,Symmons DP,BSR Biologics Register.

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To examine the effect of infliximab plus methotrexate (MTX) compared with placebo plus MTX on bone loss in patients with early rheumatoid arthritis (RA) in a double-blind randomised study design. Further, to explore the associations between bone loss and markers of RA disease. METHODS:All 20 patients with RA...

journal_title：Annals of the rheumatic diseases

authors： Haugeberg G,Conaghan PG,Quinn M,Emery P

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The PTPN22 gene has been widely confirmed as a susceptibility gene for rheumatoid arthritis (RA) in populations of Northern European descent. The aim of the current study was to explore the role of variants spanning the PTPN22 gene in determining susceptibility to and outcome of inflammatory polyarthritis (I...

journal_title：Annals of the rheumatic diseases

authors： Naseem H,Thomson W,Silman A,Worthington J,Symmons D,Barton A

更新日期：2008-02-01 00:00:00

abstract：:The circulating levels of hyaluronate were determined in 36 patients with scleroderma and in 36 control subjects matched for age and sex. The mean serum hyaluronate concentration in patients with progressive systemic sclerosis (n = 25) was 131 +/- 67 (SD) microgram/l and significantly greater (p less than 0.001) than ...

journal_title：Annals of the rheumatic diseases

authors： Engström-Laurent A,Feltelius N,Hällgren R,Wasteson A

更新日期：1985-09-01 00:00:00

abstract：:A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other t...

journal_title：Annals of the rheumatic diseases

authors： Allard SA,King RH,Thomas PK,Bourke BE

更新日期：1991-11-01 00:00:00

abstract：:A patient with rheumatoid arthritis (RA), vasculitis, and aortic valve incompetence of the histologically nonspecific type is described. Valve replacement was undertaken, and an excellent haemodynamic result was achieved. Both arthritis and vasculitis subsequently remitted. Valve replacement can be successfully perfor...

journal_title：Annals of the rheumatic diseases

authors： Liew M,Wilson D,Horton D,Fleming A

更新日期：1979-10-01 00:00:00