Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity.

abstract：OBJECTIVES:To study the reliability and construct validity of ultrasound in interphalangeal finger joints affected by erosive osteoarthritis (EOA) and non-EOA with MRI as the reference method. METHODS:252 joints were examined by ultrasound, conventional radiography and clinical examination. Ultrasound was performed us...

journal_title：Annals of the rheumatic diseases

authors： Wittoek R,Jans L,Lambrecht V,Carron P,Verstraete K,Verbruggen G

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:To assess the interobserver agreement on the diagnostic classification of shoulder disorders, based on history taking and physical examination, and to identify the determinants of diagnostic disagreement. METHODS:Consecutive eligible patients with shoulder pain were recruited in various health care settings...

journal_title：Annals of the rheumatic diseases

authors： de Winter AF,Jans MP,Scholten RJ,Devillé W,van Schaardenburg D,Bouter LM

更新日期：1999-05-01 00:00:00

abstract：:The case is reported of a 27 year old woman who had mixed connective tissue disease (MCTD) associated with chronic active hepatitis and thyroiditis. Although hepatomegaly is sometimes observed in MCTD, only four cases of MCTD and chronic active hepatitis have been described. It is thought that this is the first report...

journal_title：Annals of the rheumatic diseases

authors： Tomsic M,Ferlan-Marolt V,Kveder T,Hojker S,Rozman B

更新日期：1992-04-01 00:00:00

abstract：:Serum samples were obtained from patients with polymyalgia rheumatica (PMR: n = 10) or giant cell arteritis (GCA; n = 7), or both. Samples were taken either before treatment or within one week of starting prednisolone. Immune complexes (IC) were concentrated by polyethylene glycol (PEG) precipitation then purified wit...

journal_title：Annals of the rheumatic diseases

authors： Smith AJ,Kyle V,Cawston TE,Hazleman BL

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) tends to remit during pregnancy, with more patients achieving remission in the third trimester, coinciding with an increase in levels of alpha-fetoprotein (AFP). In vitro and animal studies have shown that AFP has immunomodulatory properties. MM-093 is a non-glycosylated, recombinan...

journal_title：Annals of the rheumatic diseases

authors： Pollard LC,Murray J,Moody M,Stewart EJ,Choy EH

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Serum leptin measures are associated with radiographic knee osteoarthritis, but no studies have examined leptin levels with respect to different measures of knee joint damage from MRI. METHODS:Participants in the Michigan Study of Women's Health Across the Nation underwent bilateral knee MRIs ...

journal_title：Annals of the rheumatic diseases

authors： Karvonen-Gutierrez CA,Harlow SD,Jacobson J,Mancuso P,Jiang Y

更新日期：2014-05-01 00:00:00

abstract：:Free thiomalate is measureable in the plasma and urine of patients with rheumatoid arthritis receiving sodium aurothiomalate (Myocrisin). Plasma concentrations and urinary excretion of free thiomalate were measured in 8 patients by high-performance liquid chromatography and electrochemical detection. After an initial ...

journal_title：Annals of the rheumatic diseases

authors： Rudge SR,Perrett D,Swannell AJ

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:The study aimed to evaluate the use of positron emission tomography/computed tomography (PET/CT) with (68)Ga-PRGD2 as the tracer for imaging of synovial angiogenesis in patients with rheumatoid arthritis (RA). METHODS:Twenty untreated active patients with RA underwent (68)Ga-PRGD2 PET/CT and (18)F-FDG PET/C...

journal_title：Annals of the rheumatic diseases

authors： Zhu Z,Yin Y,Zheng K,Li F,Chen X,Zhang F,Zhang X

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The British Society for Rheumatology Biologics Register (BSRBR) has collected data on adverse events including pregnancies in patients with rheumatoid arthritis treated with anti-tumour necrosis factor (anti-TNF) therapy. The purpose of this report is to summarise the pregnancy outcomes in women treated with ...

journal_title：Annals of the rheumatic diseases

authors： Verstappen SM,King Y,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium, BSR Biologics Register.

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To investigate the production of the matrix metalloproteinase (MMP), collagenase (MMP-1), and its natural inhibitor, the tissue inhibitor of metalloproteinases (TIMP) by diseased human tendon samples in organ culture. METHODS:Portions of tendons were excised from the shoulders of patients undergoing shoulder...

journal_title：Annals of the rheumatic diseases

authors： Dalton S,Cawston TE,Riley GP,Bayley IJ,Hazleman BL

更新日期：1995-07-01 00:00:00

abstract：:Structural damage assessed on conventional radiographs is an important outcome measure in psoriatic arthritis. This article reviews the available scoring methods. A full description of the methods is given as well as information on various aspects of validity. ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde D,Sharp J,Wassenberg S,Gladman DD

更新日期：2005-03-01 00:00:00

abstract：:Short term immobilisation (seven days) of an antigen induced arthritic knee joint of the mouse led to attachment of polymorphonuclear leucocytes to the cartilage surface and severe cartilage damage. The events at the patellar cartilage surface were studied by scanning electron microscopy and compared with the changes ...

journal_title：Annals of the rheumatic diseases

authors： van Lent PL,Wilms FH,van den Berg WB

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:In a prospective observational study, we investigated whether patients with active systemic lupus erythematosus (SLE) had higher indices of endothelial damage and dysfunction than healthy controls and whether improved disease control was associated with improvement in these indices. METHODS:Twenty-seven pat...

journal_title：Annals of the rheumatic diseases

authors： Parker B,Al-Husain A,Pemberton P,Yates AP,Ho P,Gorodkin R,Teh LS,Alexander MY,Bruce IN

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:While it is now clear that paracetamol is ineffective for spinal pain, there is not consensus on the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for this condition. We performed a systematic review with meta-analysis to determine the efficacy and safety of NSAIDs for spinal pain. METHODS:We s...

journal_title：Annals of the rheumatic diseases

authors： Machado GC,Maher CG,Ferreira PH,Day RO,Pinheiro MB,Ferreira ML

更新日期：2017-07-01 00:00:00

abstract：:This paper presents the second update of the Assessment in SpondyloArthritis international Society (ASAS) consensus statement on the use of anti-tumour necrosis factor (anti-TNF) agents in patients with axial spondyloarthritis (SpA). A major change from the previous recommendations is that patients fulfilling the ASAS...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde D,Sieper J,Maksymowych WP,Dougados M,Burgos-Vargas R,Landewé R,Rudwaleit M,Braun J,Assessment of SpondyloArthritis international Society.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To determine the relevance of calpain in murine collagen induced arthritis (CIA) and to correlate the presence of m-calpain with the appearance of arthritis and cartilage destruction. METHODS:The immunohistochemical appearance and localisation of m-calpain at different stages of arthritis were analysed and ...

journal_title：Annals of the rheumatic diseases

authors： Szomor Z,Shimizu K,Fujimori Y,Yamamoto S,Yamamuro T

更新日期：1995-06-01 00:00:00

abstract：:There is no agreement as to which variable best mirrors disease activity in rheumatoid arthritis (RA) and no studies have been performed on the validity of disease activity variables. In this study the validity of 10 commonly used single variables and three composite indices was tested. All patients participated in a ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde DM,van't Hof MA,van Riel PL,van Leeuwen MA,van Rijswijk MH,van de Putte LB

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation. OBJECTIVE:To evaluate markers of cartilage and bone turnover in patients with chondromalacia patellae. METHODS:18 patients with chondromalacia patellae were studied. Serum cartilage olig...

journal_title：Annals of the rheumatic diseases

authors： Murphy E,FitzGerald O,Saxne T,Bresnihan B

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...

journal_title：Annals of the rheumatic diseases

authors： Belcher C,Yaqub R,Fawthrop F,Bayliss M,Doherty M

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence up...

journal_title：Annals of the rheumatic diseases

authors： Schaefer CJ,Lawrence WD,Wooley PH

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Gout, the most common inflammatory arthritis, is associated with premature mortality. Whether this mortality gap has improved over time, as observed in rheumatoid arthritis (RA), is unknown. METHODS:Using an electronic medical record database representative of the UK general population, we identified inciden...

journal_title：Annals of the rheumatic diseases

authors： Fisher MC,Rai SK,Lu N,Zhang Y,Choi HK

更新日期：2017-07-01 00:00:00

abstract：:The capacity of monocytes from patients with rheumatoid arthritis to generate superoxide anion in vitro after stimulation with serum treated zymosan (STZ) or IgG treated zymosan (IgTZ) was studied before and during therapy with penicillamine (n = 9) or sodium aurothiomalate (AuTM) (n = 12). Significant increases in ra...

journal_title：Annals of the rheumatic diseases

authors： Hurst NP,Bell AL,Nuki G

更新日期：1986-01-01 00:00:00

abstract：:HLA A, B, and C antigens were studied in 25 patients with ankylosing hyperostosis. There was no evidence of an increased frequency of any antigen in association with the condition itself. However, a high frequency of several antigens was found, reflecting the predominance of Jewish patients in the series. ...

journal_title：Annals of the rheumatic diseases

authors： Perry JD,Wolf H,Festenstein H,Storey GO

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to analyse retrospectively adult patients with acute joint or muscle symptoms and a high antistreptolysin O (ASO) titre to find out which syndromes of clinical arthritis are associated with serological evidence of streptococcal infection. METHODS:Seventy six adult patients with...

journal_title：Annals of the rheumatic diseases

authors： Valtonen JM,Koskimies S,Miettinen A,Valtonen VV

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Previous data have shown that etanercept levels are associated with clinical response in rheumatoid arthritis. However, for ankylosing spondylitis (AS), data regarding this topic are inconclusive. OBJECTIVES:To investigate the relationship between etanercept levels and clinical response in patients with AS....

journal_title：Annals of the rheumatic diseases

authors： Kneepkens EL,Krieckaert CL,van der Kleij D,Nurmohamed MT,van der Horst-Bruinsma IE,Rispens T,Wolbink GJ

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To study the ability of low-cost low-field dedicated extremity magnetic resonance imaging (E-MRI) to assess and predict erosive joint damage in the wrist and metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis. METHODS:24 previously untreated patients with rheumatoid arthritis with j...

journal_title：Annals of the rheumatic diseases

authors： Lindegaard HM,Vallø J,Hørslev-Petersen K,Junker P,Østergaard M

更新日期：2006-09-01 00:00:00

abstract：:Whole gut lavage fluid is a useful source of material for the study of intestinal immunity and inflammation in humans. Systemic and mucosal antibodies to Klebsiella pneumoniae were measured by enzyme linked immunosorbent assay (ELISA) in serum samples and whole gut lavage fluid from 14 patients with ankylosing spondyl...

journal_title：Annals of the rheumatic diseases

authors： O'Mahony S,Anderson N,Nuki G,Ferguson A

更新日期：1992-12-01 00:00:00

abstract：:A 60-year-old man with destructive rheumatoid disease, multiple nodules, and vasculitis developed a facial rash with ulceration and scarring. Histology showed granulomatous vasculitis. The rash was rapidly controlled with oral corticosteroids. Granulomatous vasculitis has not previously been reported as causing this c...

journal_title：Annals of the rheumatic diseases

authors： White R,Wegman A,Bulpitt P,Wood G,Fleming A

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:To investigate the activation of NF-kappaB in the carrageenan rat air pouch model of inflammation in a time course experiment, and the effect of dexamethasone on NF-kappaB activation. METHODS:Air pouch tissue treated with carrageenan (inflamed tissue) was obtained from rats killed at days 1, 2, 3, 6, 14, 21,...

journal_title：Annals of the rheumatic diseases

authors： Ellis L,Gilston V,Soo CC,Morris CJ,Kidd BL,Winyard PG

更新日期：2000-04-01 00:00:00