Musculoskeletal manifestations in polymyalgia rheumatica and temporal arteritis.

abstract：OBJECTIVE:To investigate the involvement of interleukin-1 (IL-1) in the induction or maintenance of the insulin-like growth factor 1 (IGF-1) non-responsive state of chondrocytes during experimental arthritis in mouse knee joints. METHODS:To characterise IGF-1 nonresponsiveness during arthritis, we measured chondrocyte...

journal_title：Annals of the rheumatic diseases

authors： Verschure PJ,Joosten LA,Van de Loo FA,Van den Berg WB

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:To assess associations between joint-specific hand symptoms and self-reported and performance-based functional status. METHODS:Participants were from the population-based Johnston County Osteoarthritis Project. Symptoms in the distal interphalangeal (DIP), proximal interphalangeal (PIP), first carpometacarpa...

journal_title：Annals of the rheumatic diseases

authors： Elliott AL,Kraus VB,Fang F,Renner JB,Schwartz TA,Salazar A,Huguenin T,Hochberg MC,Helmick CG,Jordan JM

更新日期：2007-12-01 00:00:00

abstract：:Atlanto-axial subluxation occurs with a frequency varying from 6% to 45% in rheumatoid arthritis. Most patients are treated conservatively with a cervical collar. The effectiveness of different cervical collars in inhibiting anterior atlanto-axial subluxation was tested in 11 patients with classical rheumatoid arthrit...

journal_title：Annals of the rheumatic diseases

authors： Althoff B,Goldie IF

更新日期：1980-10-01 00:00:00

abstract：OBJECTIVE:To examine the imaging-detected mechanism of reduction of structural joint damage progression by tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) using MRI. METHODS:In a substudy of a randomised, double-blind, phase 3b study (ACT-RAY) of biologic-naïve patients with RA who were methotrexate (MTX)...

journal_title：Annals of the rheumatic diseases

authors： Conaghan PG,Peterfy C,Olech E,Kaine J,Ridley D,Dicarlo J,Friedman J,Devenport J,Troum O

更新日期：2014-05-01 00:00:00

abstract：:Gout and classical rheumatoid arthritis rarely coexist. We report a patient with strong evidence for both these diseases. Possible reasons for the negative correlation between these diseases are summarised. One hypothesis suggests inhibition of surface activity of monosodium urate crystals (MSU) by binding of rheumato...

journal_title：Annals of the rheumatic diseases

authors： Gordon TP,Ahern MJ,Reid C,Roberts-Thomson PJ

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:Factors contributing to the development of systemic lupus erythematosus (SLE) remain largely unknown although are likely to include both environmental and genetic components. Studies on murine lupus have indicated a role for an antibody that blocks binding of cytotoxic T lymphocyte associated-4 (CTLA-4) to B...

journal_title：Annals of the rheumatic diseases

authors： Heward J,Gordon C,Allahabadia A,Barnett AH,Franklyn JA,Gough SC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To assess the expression of ICAM1, VCAM1, E-selectin, CD44, and TNF alpha in labial salivary glands of patients with rheumatoid vasculitis. METHODS:Labial salivary glands from six patients with rheumatoid vasculitis before and after treatment, six aged matched rheumatoid arthritis patients without clinical e...

journal_title：Annals of the rheumatic diseases

authors： Flipo RM,Cardon T,Copin MC,Vandecandelaere M,Duquesnoy B,Janin A

更新日期：1997-01-01 00:00:00

abstract：:Six measurements of joint mobility were made in a group of 446 normal adolescents. A method of measuring hip and knee rotation is presented. All these data are normally distributed, and would suggest that joint hypermobility lies at the end of the normal spectrum. There was a weak but significant correlation between e...

journal_title：Annals of the rheumatic diseases

authors： Fairbank JC,Pynsent PB,Phillips H

更新日期：1984-04-01 00:00:00

abstract：:Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were ...

journal_title：Annals of the rheumatic diseases

authors： Smith MD,Roberts-Thomson PJ

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of the immunotherapeutic vaccine interferon-α kinoid (IFN-K) in a 36-week (W) phase IIb, randomised, double-blind, placebo (PBO)-controlled trial in adults with active systemic lupus erythematosus (SLE) despite standard of care. METHODS:Patients with SLE (185) with moderat...

journal_title：Annals of the rheumatic diseases

authors： Houssiau FA,Thanou A,Mazur M,Ramiterre E,Gomez Mora DA,Misterska-Skora M,Perich-Campos RA,Smakotina SA,Cerpa Cruz S,Louzir B,Croughs T,Tee ML

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of the skin and the internal organs. Except for anticentromere, antitopoisomerase I and antipolymerase III antibodies, there are no reliable circulating markers predicting susceptibility and internal organ complications. This study h...

journal_title：Annals of the rheumatic diseases

authors： van Bon L,Cossu M,Loof A,Gohar F,Wittkowski H,Vonk M,Roth J,van den Berg W,van Heerde W,Broen JC,Radstake TR

更新日期：2014-08-01 00:00:00

abstract：:A previously normal 58-year-old woman developed a widespread psoriatic rash and asymmetrical peripheral polyarthritis a week after beginning treatment with oxprenolol for hypertension. Skin and joint disease resolved simultaneously after drug withdrawal and have not recurred. ...

journal_title：Annals of the rheumatic diseases

authors： Macfarlane DG,Settas L

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVES:Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. METHODS:A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing ...

journal_title：Annals of the rheumatic diseases

authors： Reginster JY,Dudler J,Blicharski T,Pavelka K

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Little data are available regarding the rate and predicting factors of serious infections in patients with rheumatoid arthritis (RA) treated with abatacept (ABA) in daily practice. We therefore addressed this issue using real-life data from the Orencia and Rheumatoid Arthritis (ORA) registry. METHODS:ORA is...

journal_title：Annals of the rheumatic diseases

authors： Salmon JH,Gottenberg JE,Ravaud P,Cantagrel A,Combe B,Flipo RM,Schaeverbeke T,Houvenagel E,Gaudin P,Loeuille D,Rist S,Dougados M,Sibilia J,Le Loët X,Meyer O,Solau-Gervais E,Marcelli C,Bardin T,Pane I,Baron G,Perrod

更新日期：2016-06-01 00:00:00

abstract：:The prevalence of grade III or IV osteoarthritis was determined in 210 patients with chronic renal failure, of whom 94 were receiving chronic haemodialysis and 116 had functioning renal transplants. The prevalence of grade III or IV osteoarthritis was three times greater in patients under 65 than in a control populati...

journal_title：Annals of the rheumatic diseases

authors： Duncan IJ,Hurst NP,Sebben R,Milazzo SC,Disney A

更新日期：1990-06-01 00:00:00

abstract：:A 62 year old woman taking L-tryptophan developed eosinophilic fasciitis shortly after starting an exercise class. She received prednisone without benefit but improved after azathioprine treatment was started and L-tryptophan was discontinued. As products containing L-tryptophan have recently been implicated in develo...

journal_title：Annals of the rheumatic diseases

authors： Hamilton ME

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjögren syndrome. METHODS:Cryostat sections of labial salivary glands from 15 patients with primary Sjögren syndrome were examined by an indirect immunoperoxidase technique and monoclonal antibodies to a pa...

journal_title：Annals of the rheumatic diseases

authors： Aziz KE,McCluskey PJ,Wakefield D

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Persistent fibroblast activation initiated by transforming growth factor β (TGF-β) is a fundamental event in the pathogenesis of systemic sclerosis, and its pharmacological inhibition represents a potential therapeutic strategy. The nuclear receptor, peroxisome proliferator-activated receptor γ (PPAR-γ), exe...

journal_title：Annals of the rheumatic diseases

authors： Wei J,Zhu H,Komura K,Lord G,Tomcik M,Wang W,Doniparthi S,Tamaki Z,Hinchcliff M,Distler JH,Varga J

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Interferon (IFN) beta displays anti-inflammatory and immunosuppressive activity and has been considered for the treatment of rheumatoid arthritis (RA). Information about the effects of this molecule on joint cells is scarce, however. OBJECTIVE:To investigate the effects of IFNbeta on the production of inter...

journal_title：Annals of the rheumatic diseases

authors： Palmer G,Mezin F,Juge-Aubry CE,Plater-Zyberk C,Gabay C,Guerne PA

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To measure gelatinase activities in paired synovial fluid (SF) and serum of patients with juvenile idiopathic arthritis (JIA), and to assess how these activities relate to clinical and laboratory measures of disease activity. METHODS:A quantitative protein substrate zymography method was adapted and validate...

journal_title：Annals of the rheumatic diseases

authors： Peake NJ,Foster HE,Khawaja K,Cawston TE,Rowan AD

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Hand exercises are recommended for patients with hand osteoarthritis (HOA), though evidence for their effect is conflicting. OBJECTIVE:To evaluate, in a randomised controlled trial, the effect of HOA information plus home-based hand exercises (exercise group) compared with information only (control group) i...

journal_title：Annals of the rheumatic diseases

authors： Hennig T,Hæhre L,Hornburg VT,Mowinckel P,Norli ES,Kjeken I

更新日期：2015-08-01 00:00:00

abstract：:Arthralgias have previously been reported in association with acne fulminans, but the following case in the first report of osseous lesions associated with this disease. The destructive bony lesion was rapid in onset but self-limited. ...

journal_title：Annals of the rheumatic diseases

authors： Hunter LY,Hensinger RN

更新日期：1980-08-01 00:00:00

abstract：AIMS:The aim of this work was to assess the feasibility of using dynamic contrast enhanced (DCE) MRI of bone marrow oedema, to compare it with conventional marrow oedema scoring systems, and to determine the effects of anti-tumour necrosis factor (TNF)alpha therapy. METHODS:The wrist and metacarpophalangeal (MCP) join...

journal_title：Annals of the rheumatic diseases

authors： Hodgson R,Grainger A,O'Connor P,Barnes T,Connolly S,Moots R

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether anti-Saccharomyces cerevisiae antibodies (ASCA), a marker for Crohn's disease (CD), are present in spondyloarthropathies (SpA) and in the subgroups ankylosing spondylitis (AS), undifferentiated SpA (uSpA), and psoriatic arthritis (PsA), in comparison with healthy and inflammatory contr...

journal_title：Annals of the rheumatic diseases

authors： Hoffman IE,Demetter P,Peeters M,De Vos M,Mielants H,Veys EM,De Keyser F

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA). OBJECTIVE:To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the ...

journal_title：Annals of the rheumatic diseases

authors： Britsemmer K,Ursum J,Gerritsen M,van Tuyl LH,van Schaardenburg D

更新日期：2011-08-01 00:00:00

abstract：:In a multicentre study patients with rheumatoid arthritis judged by prevailing criteria to be suitable for synovectomy of the knee or metacarpophalangeal (MCP) joints were randomly allocated to one of two groups. One group had the operation, the other was observed without operation from a notional corresponding date. ...

journal_title：Annals of the rheumatic diseases

authors：

更新日期：1975-10-01 00:00:00

abstract：OBJECTIVE:To determine whether 17beta-oestradiol (E2) modulates interleukin (IL) 1beta-induced proteoglycan degradation in chondrocytes, and to analyse the part played by metalloproteinases (MMPs) in this process. METHODS:Primary cultured rabbit articular chondrocytes were prepared and treated with 10 ng/ml IL1beta co...

journal_title：Annals of the rheumatic diseases

authors： Richette P,Dumontier MF,François M,Tsagris L,Korwin-Zmijowska C,Rannou F,Corvol MT

更新日期：2004-02-01 00:00:00

abstract：:The rapid introduction of immunotherapies for cancer-targeting immunological checkpoints has led to a new class of toxicities that appear to be of autoimmune and or autoinflammatory origin. These disorders are now referred to as immune-related adverse events (irAEs) and pose considerable challenges to patient care in ...

journal_title：Annals of the rheumatic diseases

authors： Calabrese L,Mariette X

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Although natural regulatory T cells (nTregs) can suppress osteoclastogenesis, the role of TGF-β-induced CD4+Foxp3+ Tregs (iTregs) in osteoclastogenesis remains unknown. OBJECTIVE:To determine the effects of iTregs on osteoclastogenesis in vitro and on bone erosion in vivo in collagen-induced arthritis (CIA)...

journal_title：Annals of the rheumatic diseases

authors： Kong N,Lan Q,Su W,Chen M,Wang J,Yang Z,Park R,Dagliyan G,Conti PS,Brand D,Liu Z,Stohl W,Zou H,Zheng SG

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously t...

journal_title：Annals of the rheumatic diseases

authors： Bergmann C,Brandt A,Merlevede B,Hallenberger L,Dees C,Wohlfahrt T,Pötter S,Zhang Y,Chen CW,Mallano T,Liang R,Kagwiria R,Kreuter A,Pantelaki I,Bozec A,Abraham D,Rieker R,Ramming A,Distler O,Schett G,Distler JHW

更新日期：2018-01-01 00:00:00