Changing pattern in the prescription of biological treatment in rheumatoid arthritis. A 7-year follow-up of 1839 patients in southern Sweden.

abstract：OBJECTIVES:MRI is recommended in the diagnostic process of rheumatoid arthritis (RA) to detect joint damage early. MRI-detected erosions are also present in symptom-free controls, especially at older age. It is unclear if RA-specific MRI-detected erosions can be distinguished from 'physiological' erosions in symptom-fr...

journal_title：Annals of the rheumatic diseases

authors： Boeters DM,Nieuwenhuis WP,van Steenbergen HW,Reijnierse M,Landewé RBM,van der Helm-van Mil AHM

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To assess the effects of tumour necrosis factor (TNF) antagonist therapy on B lymphocyte stimulator (BLyS) expression in patients with rheumatoid arthritis (RA). METHODS:Blood from 38 patients with RA from a single centre was collected prior to and following initiation of TNF antagonist therapy. Plasma BLyS ...

journal_title：Annals of the rheumatic diseases

authors： La DT,Collins CE,Yang HT,Migone TS,Stohl W

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously t...

journal_title：Annals of the rheumatic diseases

authors： Bergmann C,Brandt A,Merlevede B,Hallenberger L,Dees C,Wohlfahrt T,Pötter S,Zhang Y,Chen CW,Mallano T,Liang R,Kagwiria R,Kreuter A,Pantelaki I,Bozec A,Abraham D,Rieker R,Ramming A,Distler O,Schett G,Distler JHW

更新日期：2018-01-01 00:00:00

abstract：:Thirty-three patients with early peripheral synovitis were followed up for two to four years in order to study the relationship between fluctuations in rheumatoid factor (RF) levels and indices of clinical activity. Twenty-eight of these patients developed classical/definite rheumatoid arthritis (RA). Seventeen patien...

journal_title：Annals of the rheumatic diseases

authors： Withrington RH,Teitsson I,Valdimarsson H,Seifert MH

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:To study the risk of a second malignant neoplasm (SMN) and mortality in patients with rheumatoid arthritis (RA) with a history of a primary cancer diagnosis and treated with biological disease-modifying antirheumatic drugs (bDMARD). METHODS:Among patients with RA (n=15 286) registered in the DANBIO Register ...

journal_title：Annals of the rheumatic diseases

authors： Dreyer L,Cordtz RL,Hansen IMJ,Kristensen LE,Hetland ML,Mellemkjaer L

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Human bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functio...

journal_title：Annals of the rheumatic diseases

authors： Bocelli-Tyndall C,Trella E,Frachet A,Zajac P,Pfaff D,Geurts J,Heiler S,Barbero A,Mumme M,Resink TJ,Schaeren S,Spagnoli GC,Tyndall A

更新日期：2015-01-01 00:00:00

abstract：:Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associ...

journal_title：Annals of the rheumatic diseases

authors： Clegg DO,Zone JJ,Samuelson CO Jr,Ward JR

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS:The review included current disease activity using data from clinical assessment and...

journal_title：Annals of the rheumatic diseases

authors： Sokka T,Kautiainen H,Toloza S,Mäkinen H,Verstappen SM,Lund Hetland M,Naranjo A,Baecklund E,Herborn G,Rau R,Cazzato M,Gossec L,Skakic V,Gogus F,Sierakowski S,Bresnihan B,Taylor P,McClinton C,Pincus T,QUEST-RA Group.

更新日期：2007-11-01 00:00:00

abstract：:Only a minority (7/35, 20%) of synovial fluids from patients with rheumatoid arthritis (RA) and none from patients with other arthritides stimulated the oxidative response of polymorphonuclear leucocytes (PMNs). Superoxide anion generation was measured by superoxide dismutase inhibitable reduction of cytochrome c. The...

journal_title：Annals of the rheumatic diseases

authors： Dularay B,Badesha JS,Dieppe PA,Elson CJ

更新日期：1990-09-01 00:00:00

abstract：:Synovial fluid isolated from 16 patients with rheumatoid arthritis activated luminol dependent chemiluminescence in bloodstream neutrophils, and the maximal activity stimulated varied over a 50-fold range. In contrast, these same fluids only activated a much lower range (two- to threefold) of maximal rates of lucigeni...

journal_title：Annals of the rheumatic diseases

authors： Nurcombe HL,Bucknall RC,Edwards SW

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of age on the effectiveness and tolerance of antitumour necrosis factor alpha (TNFalpha) therapy in rheumatoid arthritis (RA). METHODS:730 patients of the Dutch Rheumatoid Arthritis Monitoring (DREAM) register were categorised into three groups according to their age at initiatio...

journal_title：Annals of the rheumatic diseases

authors： Radovits BJ,Kievit W,Fransen J,van de Laar MA,Jansen TL,van Riel PL,Laan RF

更新日期：2009-09-01 00:00:00

abstract：:Erosions on the triquetrum and pisiform are frequent in early rheumatoid arthritis and occur characteristically at 3 sites. (a) A shallow erosion on the proximal medial triquetral "bare" area is related to synovial proliferation at the margin of the radiocarpal cavity, although compressive forces from an adjacent long...

journal_title：Annals of the rheumatic diseases

authors： Resnick D

更新日期：1976-02-01 00:00:00

abstract：:A 15 year old girl who had pain, oedema of her left hand, and fever of four months' duration is described. Marked demineralisation of her hand was shown by radiography, and increased articular uptake by technetium-99m bone scan. All these changes were indistinguishable from reflex sympathetic dystrophy. After two admi...

journal_title：Annals of the rheumatic diseases

authors： Rodriguez-Moreno J,Ruiz-Martin JM,Mateo-Soria L,Rozadilla A,Roig-Escofet D

更新日期：1990-12-01 00:00:00

abstract：:The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

journal_title：Annals of the rheumatic diseases

authors： Stevenson AC,Silcock SR,Scott JT

更新日期：1976-04-01 00:00:00

abstract：OBJECTIVE:Technetium-99m ethyl cysteinate dimer (99mTc ECD) single photon emission computed tomography (SPECT) of the brain was used to detect abnormal regional cerebral blood flow (rCBF) in patients with primary Sjögren's syndrome (pSS) and normal findings on brain magnetic resonance imaging (MRI). METHODS:(99m)Tc EC...

journal_title：Annals of the rheumatic diseases

authors： Chang CP,Shiau YC,Wang JJ,Ho ST,Kao A

更新日期：2002-09-01 00:00:00

abstract：:Adenosine deaminase activity was determined in paired samples of serum and synovial fluid taken from patients with rheumatoid arthritis (n = 12), reactive arthritis (n = 13), and osteoarthritis (n = 7), and the value of this investigation in the diagnosis of synovial swellings was assessed. Increased activity was foun...

journal_title：Annals of the rheumatic diseases

authors： Yuksel H,Akoğlu TF

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of golimumab over 104 weeks in patients with active ankylosing spondylitis. METHODS:At baseline, patients with active ankylosing spondylitis (n=356) were randomly assigned (1:1.8:1.8) to subcutaneous injections of placebo (group 1), golimumab 50 mg (group 2) or golimumab 100...

journal_title：Annals of the rheumatic diseases

authors： Braun J,Deodhar A,Inman RD,van der Heijde D,Mack M,Xu S,Hsu B

更新日期：2012-05-01 00:00:00

abstract：:Twenty seven patients with primary or possible Sjögren's syndrome with neurological manifestations were compared immunologically with 21 patients with Sjögren's syndrome with an intact nervous system. Patients with Sjögren's syndrome were divided into seropositive and seronegative subgroups with respect to the occurre...

journal_title：Annals of the rheumatic diseases

authors： Hietaharju A,Korpela M,Ilonen J,Frey H

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. METHODS:Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatolo...

journal_title：Annals of the rheumatic diseases

authors： Lundberg IE,Tjärnlund A,Bottai M,Werth VP,Pilkington C,Visser M,Alfredsson L,Amato AA,Barohn RJ,Liang MH,Singh JA,Aggarwal R,Arnardottir S,Chinoy H,Cooper RG,Dankó K,Dimachkie MM,Feldman BM,Torre IG,Gordon P,Hayas

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Diagnosis of active pulmonary and paranasal involvement in patients with Wegener's granulomatosis (WG) can be difficult. The diagnostic value of gallium-67 scintigraphy in WG is unclear. OBJECTIVE:To evaluate the added diagnostic value of gallium-67 scintigraphy in patients with WG with suspected granulomat...

journal_title：Annals of the rheumatic diseases

authors： Slart RH,Jager PL,Poot L,Piers DA,Tervaert JW,Stegeman CA

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To evaluate new classification criteria for peripheral spondyloarthritis (SpA) in patients with SpA with peripheral manifestations only. METHODS:In this Assessment of SpondyloArthritis international Society (ASAS) study, two prespecified sets of criteria were compared against the European Spondylarthropathy ...

journal_title：Annals of the rheumatic diseases

authors： Rudwaleit M,van der Heijde D,Landewé R,Akkoc N,Brandt J,Chou CT,Dougados M,Huang F,Gu J,Kirazli Y,Van den Bosch F,Olivieri I,Roussou E,Scarpato S,Sørensen IJ,Valle-Oñate R,Weber U,Wei J,Sieper J

更新日期：2011-01-01 00:00:00

abstract：:We describe a case of systemic sclerosis with sympathetic and parasympathetic neuropathy and detail autonomic testing in six further patients. Of these six patients, three showed early parasympathetic damage. None of the patients had evidence of peripheral neuropathy, and there was no correlation between the presence ...

journal_title：Annals of the rheumatic diseases

authors： Sonnex C,Paice E,White AG

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Immunogenicity of aTNFs is one of the mechanisms behind treatment failure. OBJECTIVE:To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab, adalimumab and etanercept, and the effect of immunosuppression on ADA detection, in patients with Rheumatoid Arthritis, Spondyloarthritis, P...

journal_title：Annals of the rheumatic diseases

authors： Garcês S,Demengeot J,Benito-Garcia E

更新日期：2013-12-01 00:00:00

abstract：:Leishmaniasis is an intracellular protozoan infection that can lead to cutaneous, mucocutaneous, visceral or systemic manifestations depending on the parasite species and virulence and on the host immune response. It is endemic in countries of Europe (Mediterranean basin), Asia, Africa, Central and South America, but ...

journal_title：Annals of the rheumatic diseases

authors： Bogdan C

更新日期：2012-04-01 00:00:00

abstract：:Adult human articular cartilage has been maintained in organ culture for 8 days, and the culture medium, which was changed on alternate days, was pooled. Normal and rheumatoid cartilage was obtained from patients and 4 types of culture were prepared: (1) cartilage alone; (2) cartilage + D-penicillamine; (3) cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Jacoby RK

更新日期：1980-02-01 00:00:00

abstract：:In view of the association of congenital heart block with maternal antibody to cellular antigen Ro (SSA), and one report linking anti-Ro with myocarditis in a patient with myositis an association between anti-Ro antibodies and cardiac disease was sought in adults with systemic lupus erythematosus (SLE). Among 67 patie...

journal_title：Annals of the rheumatic diseases

authors： Logar D,Kveder T,Rozman B,Dobovisek J

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target in osteoarthritis (OA) by studying the effects of forced mechanical loading on in vivo joint cartilage tissue homeostasis and the modulating effect herein of Dio2 deficiency. METHODS:Wild-type and C57BL/6-Dio2(-/-) -mice were s...

journal_title：Annals of the rheumatic diseases

authors： Bomer N,Cornelis FM,Ramos YF,den Hollander W,Storms L,van der Breggen R,Lakenberg N,Slagboom PE,Meulenbelt I,Lories RJ

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The RCA alpha block (Regulators of Complement Activation, 1q32) contains critical complement regulatory genes such as CR1 and MCP. This study examined RCA alpha block haplotype associations with both disease susceptibility and diversification of the anti-Ro/La autoantibody response in primary Sjögren syndrome...

journal_title：Annals of the rheumatic diseases

authors： Lester S,McLure C,Williamson J,Bardy P,Rischmueller M,Dawkins RL

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To investigate the prediction of the postpartum onset of rheumatoid arthritis (RA). METHODS:Two thousand five hundred and forty seven healthy pregnant subjects were examined prospectively and the relation between serum rheumatoid factors (RF) and postpartum onset of RA was observed. Rheumatoid factors were m...

journal_title：Annals of the rheumatic diseases

authors： Iijima T,Tada H,Hidaka Y,Yagoro A,Mitsuda N,Kanzaki T,Murata Y,Amino N

更新日期：1998-08-01 00:00:00

abstract：:Current drug development programs produce high quality data on the efficacy of new drugs, substantial data on safety, but little data on actual applicability of the new product compared to standard of care. After successful registration and launch, such data require years to accumulate and often remain incomplete. Thi...

journal_title：Annals of the rheumatic diseases

authors： Boers M

更新日期：2010-01-01 00:00:00