Abstract:
OBJECTIVE:To investigate the influence of age on the effectiveness and tolerance of antitumour necrosis factor alpha (TNFalpha) therapy in rheumatoid arthritis (RA). METHODS:730 patients of the Dutch Rheumatoid Arthritis Monitoring (DREAM) register were categorised into three groups according to their age at initiation of anti-TNFalpha therapy (<45, 45-65 and >65 years). Effectiveness of anti-TNFalpha therapy was primarily assessed by longitudinal analysis of the DAS28 during the first 12 months of treatment. RESULTS:Improvement in disease activity and physical functioning was significantly less in elderly patients, correcting for relevant confounders. Elderly patients reached the EULAR categories of good responders and remission less often than younger patients. Drug survival, co-medication use and tolerance were comparable between the three age groups. CONCLUSION:Anti-TNFalpha therapy significantly reduced disease activity in all age groups of patients; however, it appeared less effective in elderly compared with younger RA patients.
journal_name
Ann Rheum Disjournal_title
Annals of the rheumatic diseasesauthors
Radovits BJ,Kievit W,Fransen J,van de Laar MA,Jansen TL,van Riel PL,Laan RFdoi
10.1136/ard.2008.094730subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1470-3issue
9eissn
0003-4967issn
1468-2060pii
ard.2008.094730journal_volume
68pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,meta分析,多中心研究
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pub_type: 杂志文章
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