当前位置： SCI文献检索 > ANNALS OF THE RHEUMATIC DISEASES期刊下所有文献 > Lipid profile and effect of statin treatment in pooled phase II and phase III baricitinib studies.

Lipid profile and effect of statin treatment in pooled phase II and phase III baricitinib studies.

Abstract：

OBJECTIVES:Lipid profiles are altered by active disease in patients with rheumatoid arthritis (RA) and may be further modified by treatment with Janus kinase inhibitors and other disease-modifying antirheumatic drugs. METHODS:Lipid data were analysed from phase II and III studies of 4 mg (n=997) and 2 mg (n=479) oral baricitinib administered once daily in patients with moderate-to-severe active RA. Lipoprotein particle size and number and GlycA were evaluated with nuclear magnetic resonance in one phase III study. The effect of statin therapy on lipid levels was evaluated in patients on statins at baseline and in patients who initiated statins during the study. RESULTS:Treatment with baricitinib was associated with increased levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides, but no significant change in LDL-C:HDL-C ratio. Lipid levels plateaued after 12 weeks of treatment. Baricitinib treatment increased large LDL and decreased small, dense LDL particle numbers and GlycA. Lipid changes from baseline were not significantly different between baseline statin users and non-users. In patients who initiated statin therapy during the study, LDL-C, triglycerides (baricitinib 4 mg only) and apolipoprotein B decreased to pre-baricitinib levels; HDL-C and apolipoprotein A-I levels remained elevated. CONCLUSIONS:Baricitinib was associated with increased LDL-C, HDL-C and triglyceride levels, but did not alter the LDL-C:HDL-C ratio. Evaluation of cardiovascular event rates during long-term treatment is warranted to further characterise these findings and their possible clinical implications. TRIAL REGISTRATION NUMBER:NCT00902486, NCT01469013, NCT01185353, NCT01721044, NCT01721057, NCT01711359, NCT01710358, NCT01885078.

journal_name

Ann Rheum Dis

journal_title

Annals of the rheumatic diseases

authors

Taylor PC,Kremer JM,Emery P,Zuckerman SH,Ruotolo G,Zhong J,Chen L,Witt S,Saifan C,Kurzawa M,Otvos JD,Connelly MA,Macias WL,Schlichting DE,Rooney TP,de Bono S,McInnes IB

doi

10.1136/annrheumdis-2017-212461

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

988-995

issue

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2017-212461

journal_volume

pub_type

杂志文章,评审

在线工具

Lipid profile and effect of statin treatment in pooled phase II and phase III baricitinib studies.