Abstract:
:Alternative splicing (AS) is a major engine that drives proteome diversity in mammalian genomes and is a widespread cause of human hereditary diseases. More than 95% of genes in the human genome are alternatively spliced, and the most common type of AS is the cassette exon. Recent discoveries have demonstrated that the cassette exon plays an important role in genetic diseases. To discover the formation mechanism of cassette exon events, we statistically analyze cassette exons and find that cassette exon events are strongly influenced by individual exons that are smaller in size and that have a lower GC content, more codon terminations, and weaker splice sites. We propose an improved random-forest-based hybrid method of distinguishing cassette exons from constitutive exons. Our method achieves a high accuracy in classifying cassette exons and constitutive exons and is verified to outperform previous approaches. It is anticipated that this study will facilitate a better understanding of the underlying mechanisms in cassette exons.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cui Y,Cai M,Stanley HEdoi
10.1155/2017/7323508subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7323508eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9483928
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pub_type: 杂志文章,meta分析,评审
doi:10.1155/2014/468959
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doi:10.1155/2017/5984014
更新日期:2017-01-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1155/2016/4061539
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doi:10.1155/2020/5323614
更新日期:2020-05-08 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2013/571912
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2017/6352159
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6492183
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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doi:10.1155/2018/8169615
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doi:10.1155/2015/243681
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8231301
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/123078
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