Abstract:
:Papillary thyroid cancer (PTC) patients treated with thyroidectomy and radioiodine remnant ablation (RRA) often have detectable TSH-stimulated thyroglobulin (Tg) levels without localizable disease after primary treatment. To assess the value of repeat stimulated Tg assays in these patients' follow-up, we retrospectively analyzed 86 cases followed in 5 Italian thyroid-cancer referral centers. We enrolled 86 patients with PTCs treated with total/near-total thyroidectomy plus RRA between January 1,1990 and January 31, 2006. In all cases, the initial postoperative visit revealed stimulated serum Tg ≥1 ng/mL, negative Tg antibodies, and no structural evidence of disease. None received empiric radioiodine therapy. Follow-up (median: 9.6 years) included neck ultrasound and basal Tg assays (yearly) and at least 1 repeat stimulated Tg assay. Of the 86 patients analyzed (initial risk: low 63 %, intermediate 35 %, high 2 %), one (1 %) had ultrasound-detected lymph node disease and persistently elevated stimulated Tg levels at 3 years. In 17 (20 %), imaging findings were consistently negative, but the final stimulated Tg levels was still >1 ng/mL (median 2.07 ng/mL, range 1.02-4.7). The other 68 (80 %) appeared disease-free (persistently negative imaging findings with stimulated Tg levels ≤1 ng/mL). Mean intervals between first and final stimulated Tg assays were similar (5.2 and 4.8 years) in subgroups with versus without Tg normalization. Reclassification as disease-free was significantly more common when initial stimulated Tg levels were indeterminate (<10 ng/mL). In unselected PTC cohorts with incomplete/indeterminate biochemical responses to thyroidectomy and RRA, periodic remeasurement of stimulated Tg allows most patients to be classified as disease-free.
journal_name
Endocrinejournal_title
Endocrineauthors
Lamartina L,Montesano T,Trulli F,Attard M,Torlontano M,Bruno R,Meringolo D,Monzani F,Tumino S,Ronga G,Maranghi M,Biffoni M,Filetti S,Durante Cdoi
10.1007/s12020-015-0823-3subject
Has Abstractpub_date
2016-11-01 00:00:00pages
467-475issue
2eissn
1355-008Xissn
1559-0100pii
10.1007/s12020-015-0823-3journal_volume
54pub_type
杂志文章相关文献
ENDOCRINE文献大全abstract::This study was performed to ascertain whether a relationship exists between thyroid function and blood pressure in school-aged Chinese subjects without overt thyroid disease. A cross-sectional survey of 880 subjects (541 females and 339 males) aged 7-18 years in Bengbu, Anhui province was conducted. The investigation,...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-011-9517-7
更新日期:2012-02-01 00:00:00
abstract::Gonadotropin-releasing hormone (GnRH) effects on the lactotroph function have been widely studied, but they probably result from paracrine interactions. No visual data about GnRH receptor in the pituitary are available. In order to identify the GnRH target cells in the pituitary of adult rats, the cellular distributio...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02782760
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS:321 thyroid patients...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02451-w
更新日期:2020-08-10 00:00:00
abstract::Renal or hepatic impairment, often encountered in patients with type 2 diabetes, influences the pharmacokinetics and bioavailability of antihyperglycemic agents. An emerging concern is whether pharmacotherapy with incretin-based agents, the most recent drug classes to be introduced for type 2 diabetes, can be safely u...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0179-0
更新日期:2014-08-01 00:00:00
abstract::Asymmetric mRNA expression was found in preoptic anterior and hypothalamic anterior areas of the two estrogen receptor isoforms and the gonadotropin-releasing hormone. On the right side of these areas, estrogen receptor alpha mRNA expression reached its peak on estrus day, while on the left side the peak was reached o...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:21:3:251
更新日期:2003-08-01 00:00:00
abstract::PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/s12020-014-0440-6
更新日期:2015-05-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a rare disease in which the most common endocrine manifestation is diabetes insipidus (DI). Data on anterior pituitary function in patients with LCH are limited. Thus, the present study investigated anterior pituitary function in LCH patients with DI via the evaluation of clinica...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0408-6
更新日期:2015-04-01 00:00:00
abstract::The diagnostic performance of positron emission tomography using ¹¹C-methionine (MET-PET) in detecting parathyroid adenoma has been investigated by several studies with conflicting results. Aim of our study is to meta-analyze published data about this topic. A comprehensive computer literature search of studies publis...
journal_title:Endocrine
pub_type: 杂志文章,meta分析
doi:10.1007/s12020-012-9746-4
更新日期:2013-02-01 00:00:00
abstract::The thyrotropin receptor is of fundamental importance to normal thyroid function and is considered to be the predominant antigen affected by the autoantibodies of Graves' autoimmune hyperthyroidism. The identification of the epitopes on the receptor to which the autoantibodies bind or the mechanism by which the autoan...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/BF02994449
更新日期:1995-03-01 00:00:00
abstract::Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-013-9908-z
更新日期:2013-12-01 00:00:00
abstract::Nordic walking (NW), characterized by the use of two walking poles, has positive effects on several muscle groups. Muscle strength and mass decrease with age, and recently, this decrease is defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether changes in the oxidative stress m...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0360-5
更新日期:2015-04-01 00:00:00
abstract::Initiation and maintenance of labor in humans is associated with an increase in prostaglandin synthesis by intrauterine tissues. The objective of the present study was to characterize the distribution of membrane-bound PGES (mPGES) protein and mPGES mRNA in human placenta, fetal membranes, and decidua at term and to d...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:20:3:219
更新日期:2003-04-01 00:00:00
abstract::This study investigated the impact of incretin on early-phase insulin secretion and glucose excursion. The normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) groups included 16, 8, and 19 subjects, respectively. Subjects underwent continuous glucose monitoring for 3 d...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-012-9867-9
更新日期:2013-10-01 00:00:00
abstract::Fibromyalgia (FM) is a disease entity consisting of a heterogeneous cluster of symptoms that has thus far eluded identification of a causative etiology. The disease onset appears to follow physiological and/or psychological stressors and involves a subset of symptoms that are consistent with varied disorders found in ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:22:1:67
更新日期:2003-10-01 00:00:00
abstract::The peroxisome proliferator-activated receptors (PPARs)-α, -β/δ, and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, inflammation, and atherosclerosis. Our aim was to test the association between ten single nucleotide polymorph...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-014-0218-x
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:The institutional database of the Thyroid Surgery Division in China-Japan Union Hospital of Jilin University was queried to audit time trend patterns in thyroid cancer (TC) management between 2008 and 2017. METHODS:Retrospective longitudinal analysis. Clinicopathological features and treatment strategies were ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02230-7
更新日期:2020-06-01 00:00:00
abstract::The objective was to determine molecular genetic analysis of the TPO gene in Turkish children with iodide organification defect (IOD). Patients with a diagnosis of primary hypothyroidism were evaluated. Subjects having a definite diagnosis of autoimmune thyroiditis, thyroid gland dysplasia and, or iodine deficiency we...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-009-9280-1
更新日期:2010-02-01 00:00:00
abstract::Giant prolactinomas are rare tumors characterized by their large size, compressive symptoms, and extremely high prolactin secretion. The aim of this study is to describe our experience with a series of 16 giant prolactinomas cases in terms of clinical presentation, therapeutic decisions, and final outcomes. Retrospect...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1129-9
更新日期:2017-01-01 00:00:00
abstract::Circadian rhythmicity is affected in obese subjects. This article analyzes the effect of a high-fat diet (35% fat) on 24-h changes circulating prolactin, luteinizing hormone (LH), testosterone, corticosterone, thyroid-stimulating hormone (TSH) and glucose, and pineal melatonin content, in rats. When body weight of rat...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-008-9066-x
更新日期:2008-04-01 00:00:00
abstract::The possible association between low skeletal muscle mass and cardiovascular disease (CVD) risk factors necessitates estimation of muscle mass even in subjects with normal body mass index (BMI). This study was aimed to investigate optimal cutoffs for skeletal muscle mass reflecting CVD risk factors and to evaluate the...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0577-y
更新日期:2015-11-01 00:00:00
abstract:CONTEXT:Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome. CASE DESCRIPTION:We present a three-generation family with 5 affected memb...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-017-1497-9
更新日期:2018-03-01 00:00:00
abstract::Plasma levels for insulin-like growth factor-I (IGF-I) steadily increase in female rats between 20 and 40 d of life, and this increase is intimately related to the wellknown growth spurt occurring at this age. Since specific actions of IGF-I related to sexual function have been described at the ovarian and hypothalami...
journal_title:Endocrine
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Remarkable decreases in growth hormone (GH) secretion accompany healthy aging. The pathophysiology of this hyposomatotropism is confounded by concurrent changes in body composition (with increased visceral fat), physiological declines in estrogen and androgen concentrations, differences in gender responses to aging, a...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1007/BF02778061
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures. We searched for the mechanism of this interference. METHODS:Immunohistochem...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-016-1223-z
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Metabolic syndrome (MetS) is a constellation of clinical factors that indicates elevated risk of diabetes. It is diagnosed based on three or more abnormalities in its components. This does not take into account that MetS can likely present as a continuum of risk. We aim to develop a MetS severity score and asse...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-019-01970-5
更新日期:2019-07-01 00:00:00
abstract::Mineralocorticoid and glucocorticoid hormones activate the expression of the Na/K ATPase beta1 through direct binding of the mineralocorticoid receptor (MR) and glucocorticoid receptors (GR) to a mineralocorticoid- and glucocorticoid-responsive element in the beta1 promoter region, but activation of the beta1 promoter...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:13:3:287
更新日期:2000-12-01 00:00:00
abstract::To determine whether murine mammary growth is modulated by local insulin-like growth factor-1 (IGF-1) production, expression of recombinant IGF-1 was directed to the mammary glands of transgenic mice using an ovine prepro IGF-1 cDNA under control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promote...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:8:3:251
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:Bisphenol-A (BPA) is an endocrine-disrupting chemical that may affect the hormones and their receptors. The aim of this study is to determine whether BPA has an effect on the development of nonfunctional adrenal incidentaloma (NFAI). METHODS:Fifty patients who were admitted to endocrinology outpatient clinics ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-020-02502-2
更新日期:2020-09-23 00:00:00
abstract::First-line treatment of patients with growth hormone secreting adenomas is surgical resection. Disease control can be obtained by surgery (one or multiple steps), in case followed by medical treatment or adjuvant radiation therapy (radiosurgery or radiotherapy). The impact of pre-surgical treatment with somatostatin a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-015-0619-5
更新日期:2016-03-01 00:00:00
abstract::The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism L-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d. After experimental duration, T3, T...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:30:2:203
更新日期:2006-10-01 00:00:00