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Matrix Metalloproteinase 1 as a Novel Biomarker for Monitoring Hepatocellular Carcinoma in Liver Transplant Patients.

Abstract：

INTRODUCTION:Orthotopic liver transplantation (LT) is considered to be one of the few curative treatments available for early stages of hepatocellular carcinoma (HCC). Alfa-fetoprotein (AFP) is the most-used biomarker for HCC despite low sensitivity and specificity. Matrix metalloproteinase 1 (MMP-1) has been considered to be involved in the process of vascular invasion of the malignant cells. The objective of this study was to assess the use of MMP-1 for the management of HCC patients for LT. METHODS:Levels in serum of MMP-1 (ng/mL) and AFP (ng/mL) were assessed in 20 HCC patients (Milan criteria) before and 1, 6, and 12 months after LT. RESULTS:There was a strong significant correlation between levels of MMP-1 and levels of AFP (ρ = .954; P ≤ .05). There were statistical differences in the levels of MMP-1 and APF between the pre-transplantation and post-transplantation groups (1 and 12 months). Increments of both markers 6 months after LT compared with the levels 1 month after LT were detected in 4 of the 20 HCC patients. The detection of recurrence by means of imaging was coincident with the increment of both markers 6 months after LT in 3 of those 4 patients. CONCLUSIONS:After 12 months of follow-up, levels of MMP-1 were comparable to AFP levels after LT. Levels of both markers increase 6 months after LT in patients showing recurrence, indicating discriminatory power to predict relapse and thus serving as valuable markers for HCC monitoring. MMP-1 could be useful in the management of HCC after LT.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sánchez-Lorencio MI,Saenz L,Ramirez P,Villalba-López F,de la Orden V,Mediero-Valeros B,Revilla Nuin B,Gonzalez MR,Cascales-Campos PA,Ferreras-Martínez D,Noguera-Velasco JA,Díaz-Rubio E,Parrilla P

doi

10.1016/j.transproceed.2017.11.061

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

623-627

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(17)30941-7

journal_volume

50

pub_type

杂志文章

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