Magnetic resonance imaging of hyaline cartilage regeneration in neocartilage graft implantation.

Abstract:

BACKGROUND:The purpose of this study was to investigate the regenerative potential of hyaline cartilage in a neocartilage graft implant with the aid of MR cartilage imaging using a rabbit model. METHODS:Surgical osteochondral defects were created in the femoral condyles of 30 mature New Zealand rabbits. The findings of neocartilage in autologous cartilage grafts packed into osteochondral defects were compared with control group of no implant to the osteochondral defect. The outcome of the implantations was correlated with histologic and MR cartilage imaging findings over a 3-month interval. RESULTS:Neocartilage grafts packed into osteochondral defects showed regeneration of hyaline cartilage at the outer layer of the implant using MR cartilage imaging. Fibrosis of fibrocartilage developed at the outer layer of the autologous cartilage graft together with an inflammatory reaction within the osteochondral defect. CONCLUSION:This animal study provides evidence of the regenerative ability of hyaline cartilage in neocartilage transplants to repair articular cartilage.

journal_name

Transplant Proc

authors

Tan CF,Ng KK,Ng SH,Cheung YC

doi

10.1016/j.transproceed.2003.10.019

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

3105-7

issue

8

eissn

0041-1345

issn

1873-2623

pii

S004113450301114X

journal_volume

35

pub_type

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