Analysis and identification of elongated mineral particles in road coated aggregates.

abstract：:In rat skeletal muscle, chronic exposure to 50 ppm Cd2+ in drinking water produced both ultrastructural and functional damage, which took place successively and increased gradually with duration of treatment. Ultrastructurally, the first effect was a regression of the sarcoplasmic reticulum, mitochondrial cristae, and...

journal_title：Toxicology and applied pharmacology

authors： Toury R,Stelly N,Boissonneau E,Dupuis Y

更新日期：1985-01-01 00:00:00

abstract：:The current investigation was designed to determine if the pesticide methoxychlor (M) mimicked the effects of estrogen in the brain and on behavior. Running wheel activity (RWA) and sex behaviors were evaluated in this study because the role of estrogen in the regulation of these behaviors has been thoroughly establis...

journal_title：Toxicology and applied pharmacology

authors： Gray LE Jr,Ostby JS,Ferrell JM,Sigmon ER,Goldman JM

更新日期：1988-12-01 00:00:00

abstract：:Adult BALB/c mice, which are sensitive to hyperoxia (LT50 = 4.5 days 100% O2), were made tolerant to 100% O2 after treatment with butylated hydroxytoluene (BHT). Following a single ip dose of 400 mg/kg, mice survived longer periods in O2 when exposed to O2 at 7, 14, and 21, but not 2 days, following BHT injection. The...

journal_title：Toxicology and applied pharmacology

authors： Margaretten N,Tryka AF,Witschi H

更新日期：1988-10-01 00:00:00

abstract：:In previous work, we developed novel antibacterial hybrid coatings based on dextran containing dispersed Ag NPs (~5 nm, DEX-Ag) aimed to offer dual protection against two of the most common complications associated with implant surgery, infections and rejection of the implant. However, their blood-material interaction...

journal_title：Toxicology and applied pharmacology

authors： Coll Ferrer MC,Eckmann UN,Composto RJ,Eckmann DM

更新日期：2013-11-01 00:00:00

abstract：:Growing use of carbon nanotubes (CNTs) have garnered concerns regarding their association with adverse health effects. Few studies have probed how CNTs affect a host's susceptibility to pathogens, particularly respiratory viruses. We reported that exposure of lung cells and mice to pristine single-walled CNTs (SWCNTs)...

journal_title：Toxicology and applied pharmacology

authors： Chen H,Humes ST,Rose M,Robinson SE,Loeb JC,Sabaraya IV,Smith LC,Saleh NB,Castleman WL,Lednicky JA,Sabo-Attwood T

更新日期：2020-10-01 00:00:00

abstract：:Exposure of intact cultured Chinese hamster ovary (CHO) cells to water-soluble nickel (Ni) salts and to relatively water-insoluble crystalline nickel subsulfide (Ni3S2) resulted in an increased formation of the fluorescent oxidized compound, dichlorofluorescein (DCF) from the parent nonfluorescent compound, 2,7-dichlo...

journal_title：Toxicology and applied pharmacology

authors： Huang X,Frenkel K,Klein CB,Costa M

更新日期：1993-05-01 00:00:00

abstract：:The dosage-regimen-dependent teratogenicity as well as plasma and tissue levels of the antiepileptic drug valproic acid (VPA) were studied in the mouse by comparing various injection regimens and infusion of the drug via implanted osmotic minipumps. Concentrations of 225-248 micrograms VPA/ml maternal plasma (about 2X...

journal_title：Toxicology and applied pharmacology

authors： Nau H

更新日期：1985-09-15 00:00:00

abstract：:Eupafolin, a major active component found in the methanol extracts of Phyla nodiflora, has been used to treat inflammation of skin. We examined its effects on cyclooxygenase-2 (COX-2) expression in LPS-treated human dermal fibroblasts. Lipopolysaccharide (LPS) significantly increased prostaglandin-E2 (PGE2) production...

journal_title：Toxicology and applied pharmacology

authors： Tsai MH,Lin ZC,Liang CJ,Yen FL,Chiang YC,Lee CW

更新日期：2014-09-01 00:00:00

abstract：:The role of oxygen tension, insulin, and glucagon on the preservation and induction of cytochrome P450 isoenzyme activities and contents was investigated in rat hepatocytes cultured for 4 days on crude liver membrane fractions at 4 or 13% O2. At 13% O2, three out of six immunochemically analyzed P450 isoenzymes were s...

journal_title：Toxicology and applied pharmacology

authors： Saad B,Thomas H,Schawalder H,Waechter F,Maier P

更新日期：1994-06-01 00:00:00

abstract：:As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the m...

journal_title：Toxicology and applied pharmacology

authors： Wang XX,Lv X,Li SY,Hou J,Ning J,Wang JY,Cao YF,Ge GB,Guo B,Yang L

更新日期：2015-11-15 00:00:00

abstract：:Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs), commonly occur as complex mixtures in the environment. Recent studies using the zebrafish experimental model have shown that PAHs are toxic to the embryonic cardiovascular system, and that the severity and nature of this developmental card...

journal_title：Toxicology and applied pharmacology

authors： Incardona JP,Linbo TL,Scholz NL

更新日期：2011-12-01 00:00:00

abstract：:The influence of carbon monoxide (CO) on the development of systemic hypertension was studied in Dahl rats selectively bred for susceptibility (DS) and resistance (DR) to NaCl-induced hypertension. This study was designed to examine the interactions among rat line (DS or DR), NaCl content of diet, and exposure to CO. ...

journal_title：Toxicology and applied pharmacology

authors： Shiotsuka RN,Drew RT,Wehner RW

更新日期：1984-11-01 00:00:00

abstract：:Arsenic contamination of drinking water and food threatens the health of hundreds of millions of people worldwide by increasing the risk of numerous diseases. Arsenic exposure has been associated with infectious lung disease in epidemiological studies, but it is not yet understood how ingestion of low levels of arseni...

journal_title：Toxicology and applied pharmacology

authors： Goodale BC,Rayack EJ,Stanton BA

更新日期：2017-09-15 00:00:00

abstract：:Many environmental contaminants can disrupt the adaptive immune response. Exposure to the ubiquitous aryl hydrocarbon receptor (AhR) ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other agonists suppresses the antibody response. The underlying pathway mechanism by which TCDD alters B cell function is not well u...

journal_title：Toxicology and applied pharmacology

authors： Zhang Q,Kline DE,Bhattacharya S,Crawford RB,Conolly RB,Thomas RS,Andersen ME,Kaminski NE

更新日期：2013-04-01 00:00:00

abstract：:The H295R cell bioassay was used to evaluate the potential endocrine disrupting effects of 18 of the most commonly used pharmaceuticals in the United States. Exposures for 48 h with single pharmaceuticals and binary mixtures were conducted; the expression of five steroidogenic genes, 3betaHSD2, CYP11beta1, CYP11beta2,...

journal_title：Toxicology and applied pharmacology

authors： Gracia T,Hilscherova K,Jones PD,Newsted JL,Higley EB,Zhang X,Hecker M,Murphy MB,Yu RM,Lam PK,Wu RS,Giesy JP

更新日期：2007-12-01 00:00:00

abstract：:Zinc pretreatment has been shown in vitro (rat myoblasts) to induce metallothionein (MT) and inhibit cadmium (Cd)-induced protooncogenes c-myc and c-jun mRNA levels. therefore, the purpose of this study was to determine whether the mRNA expression of the protooncogene c-jun as well as the tumor suppressor gene p53 is ...

journal_title：Toxicology and applied pharmacology

authors： Zheng H,Liu J,Choo KH,Michalska AE,Klaassen CD

更新日期：1996-02-01 00:00:00

abstract：:The disappearance rate of renin from plasma was evaluated in both acutely and chronically lead-exposed rabbits. In addition, the effects of lead (Pb) on in vitro renin secretion were determined with rabbit renal cortical slices. Rabbits acutely exposed to Pb (0.3 to 2.0 mg/kg, iv) demonstrated no increase in plasma re...

journal_title：Toxicology and applied pharmacology

authors： Keiser JA,Vander AJ,Germain CL

更新日期：1983-06-15 00:00:00

abstract：:Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Ac...

journal_title：Toxicology and applied pharmacology

authors： Conklin DJ,Haberzettl P,Jagatheesan G,Kong M,Hoyle GW

更新日期：2017-06-01 00:00:00

abstract：:The biochemical and biological behavior of methylmercury (MeHg) was investigated by measurement of MeHg release rate from erythrocytes (RBC) of selected animal strains and species, by measurement of the intracellular distribution of MeHg in RBC, and by measurement of the binding affinity of hemoglobin (Hb) for MeHg. M...

journal_title：Toxicology and applied pharmacology

authors： Doi R,Tagawa M

更新日期：1983-07-01 00:00:00

abstract：:Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal. New treatment options for T2D will likely include fixed dose combinations with metformin, which may require preclini...

journal_title：Toxicology and applied pharmacology

authors： Quaile MP,Melich DH,Jordan HL,Nold JB,Chism JP,Polli JW,Smith GA,Rhodes MC

更新日期：2010-03-15 00:00:00

abstract：:In many neuropathologies activated microglia and macrophages cause neurotoxicity and prolong the inflammatory response. We have previously characterized the glycosphingolipid Neurostatin (Nst), which potentially reduces these detrimental mechanisms. Nst, isolated from mammalian brain, is the GD1b ganglioside with O-ac...

journal_title：Toxicology and applied pharmacology

authors： Yanguas-Casás N,Ojalvo-Sanz AC,Martínez-Vázquez A,Goneau MF,Gilbert M,Nieto-Sampedro M,Romero-Ramírez L

更新日期：2019-08-15 00:00:00

abstract：:We aimed to investigate the mechanisms underlying the vascular effects induced by phylloquinone (Vitamin K1; VK1). Vascular reactivity experiments, using standard muscle bath procedures, showed that VK1 (5 and 50 microM) enhances the contractile response of endothelium-intact, but not denuded, rat carotid rings to phe...

journal_title：Toxicology and applied pharmacology

authors： Tirapelli CR,De Andrade CR,Lieberman M,Laurindo FR,De Souza HP,de Oliveira AM

更新日期：2006-05-15 00:00:00

abstract：:Nafenopin was administered orally for 21 days to male Sprague-Dawley rats (0.5-50 mg/kg/day), Syrian hamsters (5-250 mg/kg/day), Dunkin-Hartley guinea pigs (50 and 250 mg/kg/day), and marmosets (Callithrix jacchus, 50 and 250 mg/kg/day). With the rat, and to a lesser extent in the hamster, nafenopin treatment produced...

journal_title：Toxicology and applied pharmacology

authors： Lake BG,Evans JG,Gray TJ,Körösi SA,North CJ

更新日期：1989-06-01 00:00:00

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:After a fire involving a transformer, the State Office Building in Binghamton, New York, was contaminated with soot containing polychlorinated biphenyls, biphenylenes, naphthalenes, dioxins, and dibenzofurans. The toxicity of the soot and its effect on liver morphology after prolonged (subchronic) exposure were determ...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1984-05-01 00:00:00

abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

journal_title：Toxicology and applied pharmacology

authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

更新日期：1993-06-01 00:00:00

abstract：:Four chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells. Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile si...

journal_title：Toxicology and applied pharmacology

authors： Mattioli F,Martelli A,Garbero C,Gosmar M,Manfredi V,Mattioli FP,Torre G,Brambilla G

更新日期：2005-03-01 00:00:00

abstract：:Following a formulation change, a leather conditioner was involved in a 1992 nationwide outbreak of respiratory illness. We investigated the composition and toxicity of the conditioner produced before (previous product) and after (new product) the disease outbreak. The new product induced tachypnea, pulmonary edema, p...

journal_title：Toxicology and applied pharmacology

authors： Hubbs AF,Castranova V,Ma JY,Frazer DG,Siegel PD,Ducatman BS,Grote A,Schwegler-Berry D,Robinson VA,Van Dyke C,Barger M,Xiang J,Parker J

更新日期：1997-03-01 00:00:00

abstract：:Technologies that generate information about the genome are being used to explore changes in gene expression and related proteins following exposure to chemicals. Conceptually, this information allows a greater understanding of genomic level mRNA expression (transcriptomics), cell and tissue protein expression (proteo...

journal_title：Toxicology and applied pharmacology

authors： Oberemm A,Onyon L,Gundert-Remy U

更新日期：2005-09-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis, lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of diabetes or hyperlipidemia, all in the absence of alcohol abuse. Given the therapeutic importance and conflicting findings regarding the po...

journal_title：Toxicology and applied pharmacology

authors： Takeuchi-Yorimoto A,Noto T,Yamada A,Miyamae Y,Oishi Y,Matsumoto M

更新日期：2013-05-01 00:00:00