Analysis and identification of elongated mineral particles in road coated aggregates.


:The issue of Elongated Mineral Particles (EMP) in building materials has been revealed during roadworks in 2013 in France. In fact, road coating aggregates are made of specific rock gravels that can contain Naturally Occurring Asbestos (NOA), which is mainly actinolite. The legislation refers to six regulatory asbestos, that consist in asbestiform habitus of the six minerals. The current technical standard is not adapted for analyzing natural material, as it cannot distinguish the asbestiform fibers and the cleavage fragments fibers. Therefore, the Eichrom Laboratories developed an internal method for analyzing rock gravel and identifying the different kind of EMP. This analytical method is based on an accurate sample preparation and three techniques at different resolutions: a petrological analysis with a stereomicroscope, a mineralogical analysis with a Polarized Light Microscope (PLM) and structural and with a Transmission Electronic Microscope (TEM). This innovative procedure is reinforced by the expertise of geologists, which is not necessary for the manufactured products. Putting the process in a national standard is essential for result homogenization of the asbestos testing laboratories.


Toxicol Appl Pharmacol


Leocat E,Rielland C,Letessier P




Has Abstract


2018-12-15 00:00:00












  • Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase.

    abstract::Epidemiological studies have demonstrated a high association of inorganic arsenic exposure with vascular diseases. Recent research has also linked this vascular damage to impairment of endothelial nitric oxide synthase (eNOS) function by arsenic exposure. However, the role of eNOS in regulating the arsenite-induced va...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Tsou TC,Tsai FY,Hsieh YW,Li LA,Yeh SC,Chang LW

    更新日期:2005-11-01 00:00:00

  • Methamphetamine and 3,4-methylenedioxymethamphetamine interact with central nicotinic receptors and induce their up-regulation.

    abstract::Previous work from our group indicated that alpha7 nicotinic acetylcholine receptors (alpha7 nAChR) potentially play a role in methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) neurotoxicity. The aims of the present study were two-fold: (1) to demonstrate the interaction of METH and MDMA with homomer...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Garcia-Ratés S,Camarasa J,Escubedo E,Pubill D

    更新日期:2007-09-15 00:00:00

  • Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans.

    abstract::The pharmacokinetics of methanol and formate were characterized in male Fischer-344 rats and rhesus monkeys exposed to methanol vapor concentrations between 50 and 2000 ppm for 6 hr. End-of-exposure blood methanol concentrations were not directly proportional to the atmospheric concentration. The methanol exposures di...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Horton VL,Higuchi MA,Rickert DE

    更新日期:1992-11-01 00:00:00

  • The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri).

    abstract::Although piperonyl butoxide (PBO) is commonly used both in vivo and in vitro as an inhibitor of cytochrome P-450-dependent monooxygenase (MO) activity in a wide variety of species, the effect of PBO on the hepatic MO of fishes has never been characterized. The MO activity in hepatic microsomes from rainbow trout expos...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Erickson DA,Goodrich MS,Lech JJ

    更新日期:1988-06-15 00:00:00

  • Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.

    abstract::Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Shmarakov IO,Lee YJ,Jiang H,Blaner WS

    更新日期:2019-10-15 00:00:00

  • Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.

    abstract::The restoration of plasma acetylcholinesterase activity in mice following inhibition by organophosphorus pesticides and nerve agents has been attributed to synthesis of new enzyme. It is generally assumed that activity levels return to normal, are stable and do not exceed the normal level. We have observed over the pa...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Duysen EG,Lockridge O

    更新日期:2011-09-01 00:00:00

  • Toluene exposure increases aminophylline-induced seizure susceptibility in mice.

    abstract::The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated. Mice were pretreated with an ip injection of corn oil or toluene (100-500 mg/kg) followed by a timed intravenous infusion of aminophylline at various time intervals to assess the seizure thresholds and lethal doses. Tolue...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Chan MH,Chen HH

    更新日期:2003-12-01 00:00:00

  • 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.

    abstract::To elucidate the underlying mechanisms in oxidative stress-related airway remodeling observed in chronic inflammatory pulmonary diseases such as asthma, we studied the effects of a thiol antioxidant, N-acetylcysteine (NAC), a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, AG-1478, and tyr...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Tsukagoshi H,Kawata T,Shimizu Y,Ishizuka T,Dobashi K,Mori M

    更新日期:2002-11-01 00:00:00

  • Strain differences in tissue concentrations of mercury in inbred mice treated with mercuric chloride.

    abstract::Tissue concentrations of mercury were determined by cold vapor atomic absorption spectrometry in different inbred mouse strains after continuous treatment with HgCl2 (3 weekly sc injections of 0.5 mg/kg bw) for up to 12 weeks. Except for the thymus, in which steadily increasing mercury concentrations were found, in st...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Griem P,Scholz E,Turfeld M,Zander D,Wiesner U,Dunemann L,Gleichmann E

    更新日期:1997-05-01 00:00:00

  • SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells.

    abstract::The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transfo...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Wu F,Jordan A,Kluz T,Shen S,Sun H,Cartularo LA,Costa M

    更新日期:2016-02-15 00:00:00

  • Aliskiren and captopril improve cognitive deficits in poorly controlled STZ-induced diabetic rats via amelioration of the hippocampal P-ERK, GSK3β, P-GSK3β pathway.

    abstract::Learning and memory deficits are obvious symptoms that develop over time in patients with poorly controlled diabetes. Hyperactivity of the renin-angiotensin system (RAS) is directly associated with β-cell dysfunction and diabetic complications, including cognitive impairment. Here, we investigated the protective and m...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Youssef MM,Abd El-Latif HA,El-Yamany MF,Georgy GS

    更新日期:2020-05-01 00:00:00

  • Predicting the oral uptake efficiency of chemicals in mammals: combining the hydrophilic and lipophilic range.

    abstract::Environmental risk assessment requires models for estimating the bioaccumulation of untested compounds. So far, bioaccumulation models have focused on lipophilic compounds, and only a few have included hydrophilic compounds. Our aim was to extend an existing bioaccumulation model to estimate the oral uptake efficiency...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: O'Connor IA,Huijbregts MA,Ragas AM,Hendriks AJ

    更新日期:2013-01-01 00:00:00

  • Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NFκB and Nrf-2/HO-1 signaling crosstalk.

    abstract::Alteration in the expression pattern of Nrf-2 and NFκB has been reported in ulcerative colitis (UC) in which functional crosstalk between these two critical pathways has been suggested. The ameliorative potential of the AT1R blocker olmesartan (OLM) on oxidative stress and inflammatory cytokines has received considera...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Saber S,Khalil RM,Abdo WS,Nassif D,El-Ahwany E

    更新日期:2019-02-01 00:00:00

  • Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice.

    abstract::The mechanism of liver cell injury induced by an overdose of the analgesic acetaminophen (AAP) remains controversial. Recently, it was hypothesized that a significant number of hepatocytes die by apoptosis. Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated thei...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Lawson JA,Fisher MA,Simmons CA,Farhood A,Jaeschke H

    更新日期:1999-05-01 00:00:00

  • Liver morphology in guinea pigs administered either pyrolysis products of a polychlorinated biphenyl transformer fluid or 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract::A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Turner JN,Collins DN

    更新日期:1983-03-15 00:00:00

  • Improving the scientific foundation for mixtures joint toxicity and risk assessment: contributions from the SOT mixtures project--introduction.

    abstract::Risk assessments are enhanced when policy and other decision-makers have access to experimental science designed to specifically inform key policy questions. Currently, our scientific understanding and science policy for environmental mixtures are based largely on extrapolating from and combining data in the observabl...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Mason AM,Borgert CJ,Bus JS,Moiz Mumtaz M,Simmons JE,Sipes IG,SOT Mixtures Task Force.

    更新日期:2007-09-01 00:00:00

  • Mercury and autoimmunity: implications for occupational and environmental health.

    abstract::Mercury (Hg) has long been recognized as a neurotoxicant; however, recent work in animal models has implicated Hg as an immunotoxicant. In particular, Hg has been shown to induce autoimmune disease in susceptible animals with effects including overproduction of specific autoantibodies and pathophysiologic signs of lup...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Silbergeld EK,Silva IA,Nyland JF

    更新日期:2005-09-01 00:00:00

  • Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis.

    abstract::Mice lacking the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in glutathione (GSH) synthesis, have decreased tissue GSH. We previously showed that Gclm-/- embryos have increased sensitivity to the prenatal in vivo ovarian toxicity of the polycyclic aromatic hydrocarbon benzo[a]pyrene ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Lim J,Luderer U

    更新日期:2018-08-01 00:00:00

  • Stimulation of rat alveolar macrophage fibronectin release in a cadmium chloride model of lung injury and fibrosis.

    abstract::Rats were exposed to saline or cadmium chloride (CdCl2) at 25, 100, or 400 micrograms/kg body weight by intratracheal instillation. At 3, 7, 14, and 28 days after exposure five animals/treatment were euthanized, the lungs were lavaged, and bronchoalveolar lavage fluid (BALF) was analyzed for lactate dehydrogenase (LDH...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Driscoll KE,Maurer JK,Poynter J,Higgins J,Asquith T,Miller NS

    更新日期:1992-09-01 00:00:00

  • Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans.

    abstract::A previously developed PBPK model for ethylene glycol and glycolic acid was extended to include glyoxylic acid, oxalic acid, and the precipitation of calcium oxalate that is associated with kidney toxicity in rats and humans. The development and evaluation of the PBPK model was based upon previously published pharmaco...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Corley RA,Saghir SA,Bartels MJ,Hansen SC,Creim J,McMartin KE,Snellings WM

    更新日期:2011-02-01 00:00:00

  • Inhibitory effect of Fusarium T2-toxin on lymphoid DNA and protein synthesis.

    abstract::The effect of T2-toxin on DNA and protein synthesis was investigated, both in vivo and in vitro. For mice which had been submitted to different treatment schedules (single dose, 3-, or 7-day treatment), the rate of DNA and protein biosynthesis was measured in thymus, bone marrow, liver, and spleen cells. T2-toxin inhi...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Rosenstein Y,Lafarge-Frayssinet C

    更新日期:1983-09-15 00:00:00

  • Online monitoring of cell metabolism for studying pharmacodynamic effects.

    abstract::To characterize modes of action of substances and their cytotoxic effects Bionas GmbH has developed a new screening system to allow the continuous recording of how an active substance can act (Bionas 2500 analyzing system). In the pharmaceutical industry it is important to acquire as much information as possible about...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Thedinga E,Kob A,Holst H,Keuer A,Drechsler S,Niendorf R,Baumann W,Freund I,Lehmann M,Ehret R

    更新日期:2007-04-01 00:00:00

  • Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.

    abstract::The M2 subtype of muscarinic receptor is predominant in heart, and such receptors were reported to be located in muscles as well as in presynaptic cholinergic and adrenergic nerve terminals. Muscarinic receptors of rat heart were identified by the high affinity binding of the agonist (+)-[3H]cis-methyldioxolane ([3H]C...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Silveira CL,Eldefrawi AT,Eldefrawi ME

    更新日期:1990-05-01 00:00:00

  • Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration.

    abstract::The murine popliteal lymph node assay (PLNA) was examined as a preclinical assay with the potential to identify low-molecular-weight compounds (LMWCs) that are likely to be associated with immune-mediated drug hypersensitivity reactions (IDHRs) in humans. We hypothesized that the contact sensitizer oxazolone (OX) woul...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Gutting BW,Bouzahzah F,Kong PL,Updyke LW,Amacher DE,Craft J

    更新日期:2003-06-01 00:00:00

  • Arsenic inhibits hedgehog signaling during P19 cell differentiation.

    abstract::Arsenic is a toxicant found in ground water around the world, and human exposure mainly comes from drinking water or from crops grown in areas containing arsenic in soils or water. Epidemiological studies have shown that arsenic exposure during development decreased intellectual function, reduced birth weight, and alt...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Liu JT,Bain LJ

    更新日期:2014-12-15 00:00:00

  • Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey.

    abstract::Naphthalene produces species and cell selective injury to respiratory tract epithelial cells of rodents. In these studies we determined the apparent Km, Vmax, and catalytic efficiency (Vmax/Km) for naphthalene metabolism in microsomal preparations from subcompartments of the respiratory tract of rodents and non-human ...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Buckpitt A,Morin D,Murphy S,Edwards P,Van Winkle L

    更新日期:2013-07-15 00:00:00

  • How do male germ cells handle DNA damage?

    abstract::Male reproductive health has received considerable attention in recent years. In addition to declining sperm quality, fertility problems and increased incidence of testicular cancer, there is accumulating evidence that genetic damage, in the form of unrepaired DNA lesions or de novo mutations, may be transmitted via s...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章,评审


    authors: Olsen AK,Lindeman B,Wiger R,Duale N,Brunborg G

    更新日期:2005-09-01 00:00:00

  • Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic.

    abstract::Epidemiological studies link arsenic exposure to increased risks of cancers of the skin, kidney, lung, bladder and liver. Additionally, a variety of non-cancerous conditions such as diabetes mellitus, hypertension, and cardiovascular disease have been associated with chronic ingestion of low levels of arsenic. However...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Pysher MD,Sollome JJ,Regan S,Cardinal TR,Hoying JB,Brooks HL,Vaillancourt RR

    更新日期:2007-10-01 00:00:00

  • DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens.

    abstract::Four chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells. Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile si...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Mattioli F,Martelli A,Garbero C,Gosmar M,Manfredi V,Mattioli FP,Torre G,Brambilla G

    更新日期:2005-03-01 00:00:00

  • Effect of plasma homocysteine level and urinary monomethylarsonic acid on the risk of arsenic-associated carotid atherosclerosis.

    abstract::Arsenic-contaminated well water has been shown to increase the risk of atherosclerosis. Because of involving S-adenosylmethionine, homocysteine may modify the risk by interfering with the biomethylation of ingested arsenic. In this study, we assessed the effect of plasma homocysteine level and urinary monomethylarsoni...

    journal_title:Toxicology and applied pharmacology

    pub_type: 杂志文章


    authors: Wu MM,Chiou HY,Hsueh YM,Hong CT,Su CL,Chang SF,Huang WL,Wang HT,Wang YH,Hsieh YC,Chen CJ

    更新日期:2006-10-01 00:00:00