Secondary Dark Reactions Following Photodynamic Treatment are More Damaging Than Previously Thought.

abstract：:The activity of the bimodal fluorescent protein (bmFP) (lambda max, 488 and 517 nm) in the in vitro luciferase reaction has been studied. The bmFP that is produced by Photobacterium phosphoreum strain bmFP is a dimer of two homologous subunits binding four riboflavin 5'-phosphate (FMN)-myristate chromophores. The addi...

journal_title：Photochemistry and photobiology

authors： Karatani H,Konaka T

更新日期：2000-02-01 00:00:00

abstract：:Proton magnetic resonance imaging (MRI) and histological methods were used to evaluate photodynamic therapy (PDT)-induced hemorrhagic necrosis in the murine M1 tumor within 72 h of treatment of male DBA/2 mice. The effects of three photosensitizing drugs were investigated: Photofrin (n = 4), Zn (II) phthalocyanine (n ...

journal_title：Photochemistry and photobiology

authors： Winsborrow BG,Grondey H,Savoie H,Fyfe CA,Dolphin D

更新日期：1997-12-01 00:00:00

abstract：:Lymphocytes treated with delta-aminolevulinic acid (ALA) can accumulate the photoactive, fluorescent heme precursor, protoporphyrin IX (PpIX). With visible light illumination, PpIX can be used in photodynamic therapy (ALA-PDT) to kill or functionally alter cells. The aim of this study was to characterize the effects o...

journal_title：Photochemistry and photobiology

authors： Hryhorenko EA,Rittenhouse-Diakun K,Harvey NS,Morgan J,Stewart CC,Oseroff AR

更新日期：1998-05-01 00:00:00

abstract：:The biguanide metformin is widely used for the treatment of Type-II diabetes. Its antiproliferative and pro-apoptotic effects in various tumor cells suggest its potential candidacy for cancer chemoprevention. Herein, we report that metformin significantly inhibited human epidermoid A431 tumor xenograft growth in nu/nu...

journal_title：Photochemistry and photobiology

authors： Chaudhary SC,Kurundkar D,Elmets CA,Kopelovich L,Athar M

更新日期：2012-09-01 00:00:00

abstract：:A targeting strategy based on the selective enzyme-mediated activation of polymeric photosensitizer prodrugs (PPP) within pathological tissue has led to the development of agents with the dual ability to detect and treat cancer. Herein, a detailed study of a simple model system for these prodrugs is described. We prep...

journal_title：Photochemistry and photobiology

authors： Campo MA,Gabriel D,Kucera P,Gurny R,Lange N

更新日期：2007-07-01 00:00:00

abstract：:This research was conducted to evaluate the design of hospital ultraviolet germicidal irradiation (UVGI) systems and to assess their effectiveness for inactivating airborne mycobacteria. A computational fluid dynamics (CFD) model was developed and tested by simulating previous experiments measuring the effectiveness o...

journal_title：Photochemistry and photobiology

authors： Xu P,Fisher N,Miller SL

更新日期：2013-07-01 00:00:00

abstract：:The aim of this investigation is the evaluation of DNA interaction of with tetraruthenated porphyrin (TRP) and of DNA damage in the presence of light. Direct-fluorescence and electronic absorption measurements after incubation of DNA with TRP indicate strong binding between pBR322 DNA or calf thymus DNA with the modif...

journal_title：Photochemistry and photobiology

authors： Onuki J,Ribas AV,Medeiros MH,Araki K,Toma HE,Catalani LH,Di Mascio P

更新日期：1996-03-01 00:00:00

abstract：:An important step in predicting the effects of future increases in UV radiation (UVR) is to evaluate the mechanisms that organisms use to prevent and repair DNA damage and determine how those mechanisms influence UVR sensitivity. Damage is prevented to varying degrees through photoprotection and repaired via two main ...

journal_title：Photochemistry and photobiology

authors： Olson MH,Mitchell DL

更新日期：2006-03-01 00:00:00

abstract：:Copper(II), in the presence of UV-B radiation (280-315 nm), can generate single-strand breaks in the sugar-phosphate backbone of pBR322 plasmid DNA. A low level of single-strand backbone breaks occurs in the presence of Cu(II) alone, but UV-B irradiation increases the rate by the more than 100-fold. Concomitant with t...

journal_title：Photochemistry and photobiology

authors： Lloyd RE,Larson RA,Adair TL,Tuveson RW

更新日期：1993-06-01 00:00:00

abstract：:Pterins are heterocyclic compounds with important biological functions, and most of them may exist in two acid-base forms in the pH range between 3 and 13 in aqueous solution. In this work, the photophysical properties of acid and basic forms of six compounds of the pterin family (6-hydroxymethylpterin [HPT], 6-methyl...

journal_title：Photochemistry and photobiology

authors： Cabrerizo FM,Petroselli G,Lorente C,Capparelli AL,Thomas AH,Braun AM,Oliveros E

更新日期：2005-09-01 00:00:00

abstract：:Efficient phagocytosis of photoreceptor outer segments (POS) membranes by retinal pigment epithelium (RPE) plays a key role in biological renewal of these highly peroxidizable structures. Here, we tested whether photodynamic treatment, mediated by merocyanine 540 (MC 540), rose Bengal or a zinc-substituted chlorophyll...

journal_title：Photochemistry and photobiology

authors： Olchawa M,Szewczyk G,Zareba M,Piłat A,Bzowska M,Mikołajczyk T,Sarna T

更新日期：2010-07-01 00:00:00

abstract：:Previous studies have reported that 450 nm blue light emitting diode (BLED) induces apoptosis through a mitochondria-mediated pathway in cancer cells and reduces the early stage tumor growth. This study was performed to determine the effects of BLED-irradiated cell metabolites on cell injury. Our results showed that c...

journal_title：Photochemistry and photobiology

authors： Oh PS,Kim EM,Kim M,Kim IS,Han YH,Lim S,Sohn MH,Ko MH,Jeong HJ

更新日期：2018-05-01 00:00:00

abstract：:Multichromophoric dyes for use in tumor imaging have been synthesized and photophysically characterized. Structurally, these dyes are dyads and triads that consist of one or two carotenoid polyenes covalently attached to hematoporphyrin (HP) or hematoporphyrin dimethyl ester (HPDME) moieties via ester linkages. The gr...

journal_title：Photochemistry and photobiology

authors： Tatman D,Liddell PA,Moore TA,Gust D,Moore AL

更新日期：1998-10-01 00:00:00

abstract：:The Photochemical Research Group from San Luis (Argentina) highlights the contributions of Dr. Norman Andino García to the development of the group as a way to show him our gratitude for all his support. ...

journal_title：Photochemistry and photobiology

authors： Ferrari G,Montaña MP

更新日期：2018-11-01 00:00:00

abstract：:A model of UV-induced DNA damage in oceanic bacterioplankton was developed and tested against previously published and novel measurements of cyclobutane pyrimidine dimers (CPD) in surface layers of the ocean. The model describes the effects of solar irradiance, wind-forced mixing of bacterioplankton and optical proper...

journal_title：Photochemistry and photobiology

authors： Huot Y,Jeffrey WH,Davis RF,Cullen JJ

更新日期：2000-07-01 00:00:00

abstract：:The photophysical properties of 1,1'-diethyl-4,4'-carbocyanine chloride (kryptocyanine) have been measured in methanol solution and for the dye bound to human serum albumin, incorporated in neutral micelles and after incubation with leukemia cells. In all cases, it is found that formation of the triplet state of the d...

journal_title：Photochemistry and photobiology

authors： Harriman A,Luengo G,Gulliya KS

更新日期：1990-10-01 00:00:00

abstract：:Vitamin A (retinol), an essential human nutrient, plays an important role in cellular differentiation, regulation of epidermal cell growth and normal cell maintenance. In addition to these physiological roles, vitamin A has a rich photochemistry. Photoisomerization of vitamin A, involved in signal transduction for vis...

journal_title：Photochemistry and photobiology

authors： Fu PP,Xia Q,Yin JJ,Cherng SH,Yan J,Mei N,Chen T,Boudreau MD,Howard PC,Wamer WG

更新日期：2007-03-01 00:00:00

abstract：:The maximum erythemal dose rate (EDRmax ) at the Earth's surface tends to occur at local noon. However, clouds can make the timing of EDRmax significantly away from local noon. In fact, EDRmax and its time of occurrence depend mainly on the solar zenith angle at noon (SZAn ), site's altitude, the total ozone column (T...

journal_title：Photochemistry and photobiology

authors： Silva AA,Yamamoto ALC,Corrêa MP

更新日期：2019-05-01 00:00:00

abstract：:Alignment of the primary structures of the hydrozoan photoproteins, aequorin, mitrocomin, clytin and obelin showed very strong amino acid sequence identities. The Ca(2+)-binding sites of the proteins were found to be highly conserved. The Ca(2+)-binding sites were also homologous to the Ca(2+)-binding sites of other C...

journal_title：Photochemistry and photobiology

authors： Tsuji FI,Ohmiya Y,Fagan TF,Toh H,Inouye S

更新日期：1995-10-01 00:00:00

abstract：:A diffusible multitherapy resistance factor (MTRF) is produced by Cloudman S91 melanoma cells in vitro. The MTRF decreases sensitivity of the target cell line, S91/amel, to gamma-irradiation, UVC (200-280 nm) and mitomycin C (MMC). In the present study, we demonstrate that MTRF also increases the survival of S91/amel ...

journal_title：Photochemistry and photobiology

authors： Hill HZ,Hill GJ,Cieszka K,Azure M,Chowdhary I,Sayre RM

更新日期：1995-05-01 00:00:00

abstract：:In this manuscript, we demonstrate the control of film thickness and surface wettability in the photochemical immobilization of poly (vinyl alcohol) (PVA) to a self-assembled monolayer (SAM) containing a phthalimide chromophore. Surface attachment is characterized by ellipsometry and contact angle measurements. The we...

journal_title：Photochemistry and photobiology

authors： Carroll GT,Turro NJ,Mammana A,Koberstein JT

更新日期：2017-10-01 00:00:00

abstract：:This research examines the behavior of ground-level solar UV radiation as measured by eight broadband meters in the continental United States during the period from late 1994 to late 1998. The goal is to define the variability that occurs in UV irradiance over time scales ranging from one to several years. The monthly...

journal_title：Photochemistry and photobiology

authors： Frederick JE,Slusser JR,Bigelow DS

更新日期：2000-10-01 00:00:00

abstract：:Central venous catheters (CVC) are widely used in the United States and are associated with 250,000 to 500,000 CVC-related infections in hospitals annually. We used a catheter made from ultraviolet-C (UVC) transmissive material to test whether delivery of UVC from the lumen would allow inactivation of microorganisms o...

journal_title：Photochemistry and photobiology

authors： Dai T,Tegos GP,St Denis TG,Anderson D,Sinofsky E,Hamblin MR

更新日期：2011-01-01 00:00:00

abstract：:We have tested the hypothesis that exposure to ultraviolet light would inhibit T helper-1 (Th1) responses and stimulate T helper-2 (Th2) responses, and that thus in a mouse model of allergic (i.e. extrinsic) asthma (using ovalbumin [OVA] as the allergen) increased symptoms would be observed, while in a model of Th1-de...

journal_title：Photochemistry and photobiology

authors： Van Loveren H,Boonstra A,Van Dijk M,Fluitman A,Savelkoul HF,Garssen J

更新日期：2000-08-01 00:00:00

abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are the major endogenous regulators of metalloproteinase activity in tissues. TIMPs are able to inhibit activity of all known matrix metalloproteinases (MMPs) and thus participate in controlling extracellular matrix synthesis and degradation. We showed previously elevate...

journal_title：Photochemistry and photobiology

authors： Ardan T,Němcová L,Bohuslavová B,Klezlová A,Popelka Š,Studenovská H,Hrnčiarová E,Čejková J,Motlík J

更新日期：2016-09-01 00:00:00

abstract：:Analysis of phosphorescence lifetimes using the Stern-Volmer equation is a reliable means of determining quencher concentration for a uniform sample. Methods of analysis for heterogeneous systems are based on the assumption that the excitation is produced by a momentary flash. This condition is an idealization because...

journal_title：Photochemistry and photobiology

authors： Golub AS,Popel AS,Zheng L,Pittman RN

更新日期：1999-06-01 00:00:00

abstract：:Advanced glycation endproducts (AGEs) have been suggested as photosensitizers that are capable of mediating eye lens photo-damage during aging. In the present work, we investigate the photo-crosslinking and oxidation of bovine lens proteins sensitized by AGEs, with special regard to low oxygen conditions. A mechanisti...

journal_title：Photochemistry and photobiology

authors： Fuentealba D,Friguet B,Silva E

更新日期：2009-01-01 00:00:00

abstract：:Photosensitizer (PS)-antibody conjugates (photoimmunoconjugates, PICs) enable cancer cell-targeted photodynamic therapy (PDT). Nonspecific chemical bioconjugation is widely used to synthesize PICs but gives rise to several shortcomings. The conjugates are heterogeneous, and the process is not easily reproducible. More...

journal_title：Photochemistry and photobiology

authors： Sadiki A,Kercher EM,Lu H,Lang RT,Spring BQ,Zhou ZS

更新日期：2020-05-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an increasingly popular anticancer treatment that uses photosensitizer, light and tissue oxygen to generate cytotoxic reactive oxygen species (ROS) within illuminated cells. Acting to counteract ROS-mediated damage are various cellular antioxidant pathways. In this study, we combined PDT ...

journal_title：Photochemistry and photobiology

authors： Kimani SG,Phillips JB,Bruce JI,MacRobert AJ,Golding JP

更新日期：2012-01-01 00:00:00

abstract：:Hypericin is a naturally occurring photosensitizer, whose presence in plants has been responsible for cutaneous phototoxicity in grazing animals. The photosensitizing properties of this agent have recently been exploited in models for anti-tumor and anti-viral activity. The cytotoxicity of hypericin and light was asse...

journal_title：Photochemistry and photobiology

authors： Yu H,Wolford ST,Kegode R,Zhao W,Osweller GD

更新日期：1996-07-01 00:00:00