The production of focal herpes encephalitis in mice by stereotaxic inoculation of virus. Anatomical and behavioral effects.

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. METHODS:35 ALS patients [23 patients presenting with limb...

journal_title：Journal of the neurological sciences

authors： Morimoto N,Kurata T,Sato K,Ikeda Y,Sato S,Abe K

更新日期：2012-08-15 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is considered a monophasic disorder yet recurrences occur in up to 6% of patients. We retrospectively studied an Italian-Japanese population of 236 GBS and 73 Miller Fisher syndrome (MFS) patients and searched for factors which may be associated with recurrence. A recurrent patient was de...

journal_title：Journal of the neurological sciences

authors： Notturno F,Kokubun N,Sekiguki Y,Nagashima T,De Lauretis A,Yuki N,Kuwabara S,Uncini A

更新日期：2016-06-15 00:00:00

abstract：PURPOSE:Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder. The underlying neural mechanisms have not been fully understood. This study aimed to examine the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in PKD using a technique called "voxel-mirro...

journal_title：Journal of the neurological sciences

authors： Ren J,Lei D,Yang T,An D,Xiao F,Li L,Huang X,Gong Q,Zhou D

更新日期：2015-04-15 00:00:00

abstract：:We investigated therapeutic effects of 4-methylcatechol (4-MC), a non-amine catechol compound, on streptozotocin (STZ)-induced diabetic neuropathy in rats. 4-MC is one of the potent stimulators of endogenous nerve growth factor (NGF) synthesis both in vitro and in vivo. Diabetic rats showed a statistically significant...

journal_title：Journal of the neurological sciences

authors： Hanaoka Y,Ohi T,Furukawa S,Furukawa Y,Hayashi K,Matsukura S

更新日期：1994-03-01 00:00:00

abstract：:The cause of amyotrophic lateral sclerosis is unknown. In this review clinical and scientific data that are pertinent to understanding this disease are reviewed. There are currently several major controversies concerning the possible role of immunological factors, genetic factors, environmental toxins, and viral infec...

journal_title：Journal of the neurological sciences

authors： Swash M,Schwartz MS

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Cladribine causes sustained reduction in peripheral T and B cell populations while sparing other immune cells. We determined two populations of dendritic cells (DCs): namely CD1c(+)/CD19(-) (myeloid DCs) and CD303(+)/CD123(+) (plasmacytoid DCs), CD19(+) B lymphocytes, CD3(+) T lymphocytes and CD4(+) or CD8(+...

journal_title：Journal of the neurological sciences

authors： Mitosek-Szewczyk K,Tabarkiewicz J,Wilczynska B,Lobejko K,Berbecki J,Nastaj M,Dworzanska E,Kolodziejczyk B,Stelmasiak Z,Rolinski J

更新日期：2013-09-15 00:00:00

abstract：:The cerebrospinal fluid tap test (CSFTT) is widely used to diagnose idiopathic normal pressure hydrocephalus (iNPH) and predict the therapeutic effectiveness of shunting. However, the ability to walk cannot be quantified for patients who are unable to walk. Therefore, we examined whether the iNPH diagnostic aid is pos...

journal_title：Journal of the neurological sciences

authors： Matsuoka T,Iida JI,Kawahara M,Uchiyama Y

更新日期：2016-12-15 00:00:00

abstract：:Weanling male Wistar rats fed a diet containing 0.5-2% cuprizone developed intramyelinic edema of the cerebellar white matter, hilum of the dentate nucleus and superior cerebellar peduncle. Oligodendrocytes in these regions showed hyperchromatic nuclei and abnormally dense cytoplasm, with an increase in the number of ...

journal_title：Journal of the neurological sciences

authors： Love S

更新日期：1988-04-01 00:00:00

abstract：:Nineteen patients with Motor Neurone Disease (MND) who had been living with their partners for at least two years prior to the onset of their illness, together with their partners, completed self-report questionnaires to investigate the impact of MND on both patients and carers. Physical disability and impact of the i...

journal_title：Journal of the neurological sciences

authors： Goldstein LH,Adamson M,Jeffrey L,Down K,Barby T,Wilson C,Leigh PN

更新日期：1998-10-01 00:00:00

abstract：:Increased resistance to ischemic nerve conduction failure (RINCF) has been demonstrated in the spontaneously diabetic BB Wistar rat as well as in non-insulin dependent but hyperglycemic litter-mates. There is marked variability in the severity of the ischemic resistance in insulin dependent rats but not in the non-ins...

journal_title：Journal of the neurological sciences

authors： Parry GJ,Kohzu H

更新日期：1989-10-01 00:00:00

abstract：:Thymomas are associated with paraneoplastic autoimmune diseases at a high frequency. It is rare that four paraneoplastic autoimmune disorders co-occur in a single patient. We describe a thymoma patient with diagnoses of myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with a thymoma. Aft...

journal_title：Journal of the neurological sciences

authors： Qiao J,Zhou G,Ding Y,Zhu D,Fang H

更新日期：2011-09-15 00:00:00

abstract：:A family with adult spinal and bulbar muscular atrophy with X-linked recessive inheritance (Kennedy's disease) is described. Affected members presented at age 20 with muscle cramps followed insidiously by gynaecomastia, partial loss of secondary sexual traits, loss of libido and inability to maintain an erection. Thre...

journal_title：Journal of the neurological sciences

authors： Arbizu T,Santamaría J,Gomez JM,Quílez A,Serra JP

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:Stiff person syndrome (SPS) is usually characterized by truncal muscle rigidity and episodic painful spasms, but it sometimes appears with ocular symptoms called "stiff eyes". We recorded saccade movements in an SPS patient manifesting with "stiff eyes" conditions with slow saccade velocity and evaluated the ...

journal_title：Journal of the neurological sciences

authors： Kodama S,Tokushige SI,Sugiyama Y,Sato K,Otsuka J,Shirota Y,Hamada M,Iwata A,Toda T,Tsuji S,Terao Y

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:The COVID-19 pandemics required several changes in stroke management and it may have influenced some clinical or functional characteristics. We aimed to evaluate the effects of the COVID-19 pandemics on stroke management during the first month of Italy lockdown. In addition, we described the emergency struct...

journal_title：Journal of the neurological sciences

authors： Naccarato M,Scali I,Olivo S,Ajčević M,Buoite Stella A,Furlanis G,Lugnan C,Caruso P,Peratoner A,Cominotto F,Manganotti P

更新日期：2020-07-15 00:00:00

abstract：OBJECTIVE:This study investigated the utility of sideline concussion tests, including components of the Sports Concussion Assessment Tool, 3rd Edition (SCAT3) and the King-Devick (K-D), a vision-based test of rapid number naming, in an outpatient, multidisciplinary concussion center treating patients with both sports-r...

journal_title：Journal of the neurological sciences

authors： Kyle Harrold G,Hasanaj L,Moehringer N,Zhang I,Nolan R,Serrano L,Raynowska J,Rucker JC,Flanagan SR,Cardone D,Galetta SL,Balcer LJ

更新日期：2017-08-15 00:00:00

abstract：:Two of the more consistent findings in Alzheimer's disease are depressions in frontal and temporoparietal glucose metabolism and a loss of cholinergic neurons in the nucleus basalis of Meynert. Nonetheless, cholinergic replacement strategies have had only minimal therapeutic successes. Whether this situation reflects ...

journal_title：Journal of the neurological sciences

authors： Blin J,Piercey MF,Giuffra ME,Mouradian MM,Chase TN

更新日期：1994-05-01 00:00:00

abstract：:Whether the primary mechanisms of migraine are vascular or neurogenic is, as yet, unresolved. In humans it is still unclear whether sumatriptan acts via constriction of dilated arteries or through other mechanisms. Doppler sonography is a non-invasive method for measuring blood flow velocities (BFV), an indirect marke...

journal_title：Journal of the neurological sciences

authors： Limmroth V,May A,Auerbach P,Wosnitza G,Eppe T,Diener HC

更新日期：1996-06-01 00:00:00

abstract：:Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for neuromyelitis optica (NMO). However, the molecular mechanism of NMO still remains unclear. The purpose of this study was to identify the possible humoral mechanisms responsible for the occurrence of astrocytic damage. Human prima...

journal_title：Journal of the neurological sciences

authors： Haruki H,Sano Y,Shimizu F,Omoto M,Tasaki A,Oishi M,Koga M,Saito K,Takahashi T,Nakada T,Kanda T

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Cognitive impairment is frequent in multiple sclerosis (MS). Tissue-specific atrophy measures have been shown to correlate with cognitive performance in several studies. Voxel-based morphometry (VBM) aims to identify regional differences in the local composition of brain tissue and makes possible to correlat...

journal_title：Journal of the neurological sciences

authors： Sastre-Garriga J,Arévalo MJ,Renom M,Alonso J,González I,Galán I,Montalban X,Rovira A

更新日期：2009-07-15 00:00:00

abstract：:We report three related patients with autosomal dominant hereditary motor and sensory neuropathy (HMSN). An unusual and characteristic feature was calf enlargement, caused by muscle fiber hypertrophy predominantly of type 1 fibers. None of the family members showed atrophy of the legs. Sural nerve pathology disclosed ...

journal_title：Journal of the neurological sciences

authors： Sakashita Y,Sakato S,Komai K,Takamori M

更新日期：1992-11-01 00:00:00

abstract：:The 3243A>G mutation of mtDNA usually is associated with MELAS syndrome. Here we report a patient with the 3243A>G mutation presenting only recurrent muscle fatigue and elevated levels of serum creatine kinase (CK). The mother of the proband was referred to us for type 2 diabetes mellitus, muscle pain and sensorineura...

journal_title：Journal of the neurological sciences

authors： Rubegni A,Cardaioli E,Chini E,Da Pozzo P,Battisti C,Malandrini A,Federico A

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by the involvement of cerebral small arteries. Although cerebral large artery disease has been reported in CADASIL patients, the prevalence and location of relevant cerebral arterial disease ...

journal_title：Journal of the neurological sciences

authors： Kang HG,Kim JS

更新日期：2015-12-15 00:00:00

abstract：:Anti-beta 2-GPI antibodies (a beta 2-GPI) were found in serum from patients with anti-phospholipid syndrome (APS) and/or systemic lupus erythematosus (SLE). Since a beta 2-GPI are often found in patients with anti-cardiolipin antibodies (aCL), their role in thrombosis as well as other central nervous system (CNS) mani...

journal_title：Journal of the neurological sciences

authors： Caronti B,Pittoni V,Palladini G,Valesini G

更新日期：1998-04-01 00:00:00

abstract：:Incidence of hip fracture among patients with Alzheimer's disease (AD), especially in elderly patients, is high. To analyze risk factors of hip fracture, we prospectively studied a cohort of elderly female patients with AD. Subjects studied were 225 female patients with AD, and the average age was 76 years old. At bas...

journal_title：Journal of the neurological sciences

authors： Sato Y,Kanoko T,Satoh K,Iwamoto J

更新日期：2004-08-30 00:00:00

abstract：BACKGROUND:The effects of smoking on clinical outcomes following acute stroke remain controversial. METHODS:We evaluated the influence of smoking on 90-day outcomes after acute atherothrombotic stroke in 292 Japanese men extracted from the database of the Edaravone and Argatroban Stroke Therapy for Acute Ischemic Stro...

journal_title：Journal of the neurological sciences

authors： Kumagai N,Okuhara Y,Iiyama T,Fujimoto Y,Takekawa H,Origasa H,Kawanishi Y,Yamaguchi T

更新日期：2013-12-15 00:00:00

abstract：:Areas of persistent demyelination were created in the dorsal columns of the cat spinal cord by injecting ethidium bromide into white matter which had previously been exposed to 40 Grays of X-irradiation. In the centre of such lesions demyelinated axons occurred in a glial-free area while axons next to normal tissue we...

journal_title：Journal of the neurological sciences

authors： Blakemore WF,Crang AJ

更新日期：1985-09-01 00:00:00

abstract：:Neocortical lesions (NLs) are an important component of multiple sclerosis (MS) pathology and may account for part of the physical and cognitive disability. Visualizing NLs of patients with MS using magnetic resonance imaging (MRI) poses several significant challenges. We optimized the inversion time (TI) of T(1)-base...

journal_title：Journal of the neurological sciences

authors： Bagnato F,Yao B,Cantor F,Merkle H,Condon E,Montequin M,Moore S,Quezado M,Tkaczyk D,McFarland H

更新日期：2009-07-15 00:00:00

abstract：:We investigated superoxide dismutase (SOD) activity in human cerebrospinal fluid (CSF) as an index of the aging process in the central nervous system (CNS). The subjects were 61 individuals aged 21-77 years, comprising 24 men and 37 women without organic disorders of the nervous system. SOD activity in CSF was measure...

journal_title：Journal of the neurological sciences

authors： Okabe T,Hamaguchi K,Inafuku T,Hara M

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Transverse myelitis is the common presentation in demyelinating conditions. OBJECTIVE:To determine the characteristics of spinal lesions among each type of demyelinating diseases. METHODS:Medical records and spinal imaging of patients who were [1] older than 18years, [2] had at least one attack of TM, [3] ...

journal_title：Journal of the neurological sciences

authors： Dumrikarnlert C,Siritho S,Chulapimphan P,Ngamsombat C,Satukijchai C,Prayoonwiwat N

更新日期：2017-01-15 00:00:00

abstract：:The pattern of mental dysfunction in multiple sclerosis (MS) is characteristic of the so-called subcortical dementia. Cognitive dysfunction results predominantly by the disruption of communication among cortical and subcortical areas, as a consequence of the white matter damage. As expected, studies with conventional ...

journal_title：Journal of the neurological sciences

authors： Comi G,Rovaris M,Leocani L,Martinelli V,Filippi M

更新日期：2000-01-15 00:00:00