Abstract：
:The pattern of mental dysfunction in multiple sclerosis (MS) is characteristic of the so-called subcortical dementia. Cognitive dysfunction results predominantly by the disruption of communication among cortical and subcortical areas, as a consequence of the white matter damage. As expected, studies with conventional magnetic resonance imaging (MRI) demonstrated that cognitive impairment in MS patients is related to the lesion burden, although the strength of this correlation is weak. This can be partially explained by the poor pathological specificity of conventional MRI techniques and by the invisible damage in the normal-appearing white matter (NAWM). Recent studies using non-conventional MRI techniques with a higher specificity for the heterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T1-weighted scans and the measurement of the magnetization transfer ratio (MTR) of whole brain, MS lesions and NAWM, support this interpretation. Other factors, such as the site of MS lesions and the presence of active inflammation, also seem to play an important role.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Comi G,Rovaris M,Leocani L,Martinelli V,Filippi Mdoi
10.1016/s0022-510x(99)00282-8subject
Has Abstractpub_date
2000-01-15 00:00:00pages
S63-6eissn
0022-510Xissn
1878-5883pii
S0022510X99002828journal_volume
172 Suppl 1pub_type
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