Abstract：
:Recently it has been reported that the C57BL mice can be used as a model of benign monoclonal gammopathy (MG). Since experimental models have until now failed to reproduce specific lesions of human dysglobulinemic polyneuropathies, we decided to investigate the peripheral nerve of these mice. The sciatic nerve and the serum from 14 C57BL mice were examined: 9 of these animals were found to have an IgG, kappa light chain MG, while in the other 5 no abnormalities were detected in the serum. In the 14 mice, features of demyelination were found in certain fibers, as well as onion-bulb formations around other myelinated fibers. Features of active demyelination were found in 10 animals and it must be underlined that three of these had no serum abnormalities. The decrease of the conduction velocities and the temperature coefficients Q10 of the C57BL mice suggest a good correlation between morphological and functional parameters. This strongly suggests that this strain of mice provides a suitable model for inflammatory demyelinating polyneuropathy (IDPN).
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Dib M,Vital A,Vital C,Georgescault D,Baquey A,Bezian Jdoi
10.1016/0022-510x(87)90188-2subject
Has Abstractpub_date
1987-10-01 00:00:00pages
101-11issue
1eissn
0022-510Xissn
1878-5883pii
0022-510X(87)90188-2journal_volume
81pub_type
杂志文章abstract：:Motor evoked potentials (MEP) were recorded in 23 patients with definite relapsing multiple sclerosis before and after treatment with a short course of high dose of methylprednisolone. MEP were performed together with clinical examination just before treatment, and 6 and 60 days later. The following results were obser...
journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/0022-510x(92)90049-q
更新日期：1992-04-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2015-02-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.jns.2009.03.028
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abstract：:Naturally occurring botulinum toxin (BoNT) serotypes have different pharmacological features of therapeutic and aesthetic interest. This phase 1, double-blind, placebo-controlled study (EudraCT: 2016-002609-20) assessed safety, tolerability and pharmacodynamics (PD) of the first recombinant BoNT serotype E (rBoNT-E) v...
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/0022-510x(88)90128-1
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更新日期：1996-12-01 00:00:00
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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更新日期：1996-03-01 00:00:00
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journal_title：Journal of the neurological sciences
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更新日期：2011-10-15 00:00:00
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更新日期：1989-02-01 00:00:00
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journal_title：Journal of the neurological sciences
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更新日期：2009-01-15 00:00:00
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更新日期：1993-04-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：1975-12-01 00:00:00
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,meta分析
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：1988-11-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,评审
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更新日期：1999-11-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,多中心研究
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更新日期：2016-02-15 00:00:00
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journal_title：Journal of the neurological sciences
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更新日期：2013-01-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2015-04-15 00:00:00
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journal_title：Journal of the neurological sciences
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更新日期：2014-05-15 00:00:00
