Antigalactocerebroside serum demyelinates optic nerve in vivo.

abstract：:Few data exist on the effects of specific Alzheimer's disease (AD)-related mutations on cognitive function. We present neuropsychological test results in eight members of a large kindred with variant Alzheimer's disease (VarAD) due to a deletion of the presenilin 1 (PS-1) gene, encompassing exon 9. The disease was neu...

journal_title：Journal of the neurological sciences

authors： Verkkoniemi A,Ylikoski R,Rinne JO,Somer M,Hietaharju A,Erkinjuntti T,Viitanen M,Kalimo H,Haltia M

更新日期：2004-03-15 00:00:00

abstract：OBJECTIVE:Cerebral gas embolism (CGE) is a potentially catastrophic complication of central venous catheters (CVCs) manipulation or accidental disconnection, which is rarely reported in the literature. This systematic review aims to characterize the clinical manifestations, imaging features and outcome of CGE associate...

journal_title：Journal of the neurological sciences

authors： Pinho J,Amorim JM,Araújo JM,Vilaça H,Ribeiro M,Pereira J,Ferreira C

更新日期：2016-03-15 00:00:00

abstract：:Hypnic headache (HH) is a rare benign disorder described initially by Raskin in 1988. It is characterized by recurrent nocturnal episodes of headache that periodically awaken the sleeping patient and usually occur in the elderly. This review is aimed at describing the clinical features of the HH cases in childhood tha...

journal_title：Journal of the neurological sciences

authors： Silva-Néto RP,Almeida KJ

更新日期：2015-09-15 00:00:00

abstract：:Neuropathological evidence of demyelination was found in the brain and sciatic nerve of diabetic patients at autopsy. The activity of acid proteinase was somewhat increased in the white matter but decreased in the gray matter of diabetic patients. No increase was observed in the activity of neutral proteinase in diabe...

journal_title：Journal of the neurological sciences

authors： Palo J,Reske-Nielsen E,Riekkinen P

更新日期：1977-08-01 00:00:00

abstract：:The cerebrospinal fluid tap test (CSFTT) is widely used to diagnose idiopathic normal pressure hydrocephalus (iNPH) and predict the therapeutic effectiveness of shunting. However, the ability to walk cannot be quantified for patients who are unable to walk. Therefore, we examined whether the iNPH diagnostic aid is pos...

journal_title：Journal of the neurological sciences

authors： Matsuoka T,Iida JI,Kawahara M,Uchiyama Y

更新日期：2016-12-15 00:00:00

abstract：:We measured the diameter of the most distal portion of the axonal initial segment, the neuronal size of anterior horn cells, and the length of the axon hillock plus the initial segment (AH+IS) in the lumbar spinal cord in motor neuron disease. Three patients with amyotrophic lateral sclerosis (ALS) and one with lower ...

journal_title：Journal of the neurological sciences

authors： Sasaki S,Maruyama S

更新日期：1992-07-01 00:00:00

abstract：:The amyloid precursor protein (APP) in brain is processed either by an amyloidogenic pathway by beta-secretase and gamma-secretase to yield Abeta (beta-amyloid 4 kDa) peptide or by alpha-secretase within the beta-amyloid domain to yield non-amyloidogenic products. We have studied blood platelet levels of a 22-kDa frag...

journal_title：Journal of the neurological sciences

authors： Tang K,Hynan LS,Baskin F,Rosenberg RN

更新日期：2006-01-15 00:00:00

abstract：:We describe a case of a 50-year-old man with bilateral shoulder girdle weakness caused by anterior subdural hygroma secondary to a previous spontaneous CSF leak. The CSF leak occurred and resolved 16 years prior to presenting with a 6-year progressive painless, asymmetric proximal muscle weakness involving both upper ...

journal_title：Journal of the neurological sciences

authors： Mihaylova T,Biondo A,Zak I,Lewis RA

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:The treatment of amyotrophic lateral sclerosis (ALS) is still disappointing. Repetitive transcranial magnetic stimulation (rTMS) has been suggested to modify the rate of disease progression in ALS. OBJECTIVE:In a pilot controlled study, we tested the effect of 5-Hz rTMS on motor performance, fatigue and qua...

journal_title：Journal of the neurological sciences

authors： Zanette G,Forgione A,Manganotti P,Fiaschi A,Tamburin S

更新日期：2008-07-15 00:00:00

abstract：:A monoclonal antibody (MAb) raised against central nervous system (CNS) myelin (212) and a MAb (308) raised against brain with Semliki Forest virus (SFV) were both found to react against the same CNS glycolipids. Both these MAbs were also found to react strongly with SFV and against certain brain glycolipid fractions ...

journal_title：Journal of the neurological sciences

authors： Khalili-Shirazi A,Gregson N,Webb HE

更新日期：1986-11-01 00:00:00

abstract：:The p53-related p73 protein is an important mediator of apoptosis, development and tumorigenesis. Previously, we showed that over-expression of the p73beta isoform induced apoptosis in proliferating neuronal cells; however, the study did not address the effect of p73 in post-mitotic neurons. To address this question, ...

journal_title：Journal of the neurological sciences

authors： Jiang Y,Lo W,Akhmametyeva EM,Chang LS

更新日期：2006-01-15 00:00:00

abstract：:We investigated superoxide dismutase (SOD) activity in human cerebrospinal fluid (CSF) as an index of the aging process in the central nervous system (CNS). The subjects were 61 individuals aged 21-77 years, comprising 24 men and 37 women without organic disorders of the nervous system. SOD activity in CSF was measure...

journal_title：Journal of the neurological sciences

authors： Okabe T,Hamaguchi K,Inafuku T,Hara M

更新日期：1996-09-15 00:00:00

abstract：:Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward s...

journal_title：Journal of the neurological sciences

authors： Santangelo G,Piscopo F,Barone P,Vitale C

更新日期：2017-03-15 00:00:00

abstract：:To compare muscle fiber loss in young and old mdx mice, we have blocked regeneration in one leg with a high dose (18 Gy) of X-rays administered at two ages; 16 days, just prior to the onset of the myopathy, and 15 weeks, when the myopathy is considered to be quiescent. Mice were examined 4 days after irradiation to lo...

journal_title：Journal of the neurological sciences

authors： Pagel CN,Partridge TA

更新日期：1999-04-01 00:00:00

abstract：:Fingerprint inclusions were identified in the skeletal muscle of a child with severe hypotonia. The mean Z-line and M-line widths from each of 19 muscle fibers containing the fingerprint inclusions were calculated. The mean Z-line widths were 85-99 nm, and the mean M-line widths were 75-101 nm. According to out presen...

journal_title：Journal of the neurological sciences

authors： Payne CM,Curless RG

更新日期：1977-04-01 00:00:00

abstract：:Focal spinal cord blood flow was measured in the left dorsal column during left sciatic nerve stimulation, and compared to blood flow in the same area during sciatic nerve inactivity. Blood flow was found to be significantly increased during stimulation. It is suggested that this increased blood flow is a reflection o...

journal_title：Journal of the neurological sciences

authors： Kobrine AI,Evans DE,Rizzoli HV

更新日期：1978-10-01 00:00:00

abstract：PURPOSE:MRI helps in detecting the etiology of epilepsy, which may assist in better management. However its role in emergency situations like status epilepticus (SE) is still not clear. We analyzed the MRI findings in various subtypes of SE and tried to find out if etiological diagnosis improves by doing MRI over and a...

journal_title：Journal of the neurological sciences

authors： Goyal MK,Sinha S,Ravishankar S,Shivshankar JJ

更新日期：2008-09-15 00:00:00

abstract：:Cerebral gliomas may cause a reduction of glucose metabolism in the cerebellum contralateral to the tumor side (crossed cerebellar diaschisis, CCD). We investigated whether CCD is related to tumor localization, histological grade, size and tumor biochemistry. Cerebellar glucose metabolism was measured in 44 glioma pat...

journal_title：Journal of the neurological sciences

authors： Otte A,Roelcke U,von Ammon K,Hausmann O,Maguire RP,Missimer J,Müller-Brand J,Radü EW,Leenders KL

更新日期：1998-01-01 00:00:00

abstract：:To evaluate the pathology of centenarian brains, which would reflect the ultimate stage of the aging process, 13 centenarians (M:F=1:12; mean+/-SD, 101.5+/-1.5 years) from the consecutive autopsy series were studied. None had severe dementia compatible with Alzheimer's disease (AD). As younger controls, 20 nondemented...

journal_title：Journal of the neurological sciences

authors： Itoh Y,Yamada M,Suematsu N,Matsushita M,Otomo E

更新日期：1998-04-15 00:00:00

abstract：:Recordings have been made from afferent fibres shown to traverse a focal demyelinating lesion induced in the dorsal columns of the cat by the direct micro-injection of lysophosphatidyl choline. Many fibres were spontaneously active, discharging with steady frequencies between 15 and 45 impulses per second or dischargi...

journal_title：Journal of the neurological sciences

authors： Smith KJ,McDonald WI

更新日期：1982-07-01 00:00:00

abstract：PURPOSE:To investigate the presence of an ethnicity bias within patients presenting with optic neuritis in London. DESIGN:Observational cross-sectional study. METHODS:The ethnicity profile of all patients attending a neuro-ophthalmology clinic in central London with acute optic neuritis over a 16month period (n=86) w...

journal_title：Journal of the neurological sciences

authors： Storoni M,Pittock SJ,Weinshenker BG,Plant GT

更新日期：2012-01-15 00:00:00

abstract：:The present study was performed to investigate the effects of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) antisense oligodeoxynucleotides (ODNs) on the assembly of the CaMKII·GluR6·PSD-95 signaling module, GluR6 serine phosphorylation and c-Jun N-terminal kinase 3 (JNK3) activation. A further aim was to det...

journal_title：Journal of the neurological sciences

authors： Liu Z,Xu J,Shen X,Lv C,Xu T,Pei D

更新日期：2012-03-15 00:00:00

abstract：INTRODUCTION:Age of onset modifiers are of considerable importance in Alzheimer's and related dementias. Arboleda-Valesquez et al., reporting on a single PSEN1 subject, suggested that homozygosity for the Christchurch variant of APOE could represent such a modifier. METHODS:We studied APOE Christchurch and Kloth-VS ge...

journal_title：Journal of the neurological sciences

authors： Yu CE,Chen S,Jayadev S,Bird T

更新日期：2020-11-15 00:00:00

abstract：:A single micro-injection of Tumour Necrosis Factor alpha (TNF) or gamma Interferon (IFN-gamma) into the lumbosacral spinal cord of the rat produced meningitis and mononuclear cuffs within the cord, an inflammatory response remarkably similar in pattern to that observed during experimental autoimmune encephalomyelitis ...

journal_title：Journal of the neurological sciences

authors： Simmons RD,Willenborg DO

更新日期：1990-12-01 00:00:00

abstract：:An improved method for identification of CSF and serum proteins is described, using analytical isoelectric focusing followed by direct immunofixation in polyacrylamide gel. This method offers high sensitivity together with retained resolution after isoelectric focusing and is technically easy to perform. The gamma-tra...

journal_title：Journal of the neurological sciences

authors： Stibler H

更新日期：1979-07-01 00:00:00

abstract：:Histone deacetylases (HDACs), or lysine deacetylases (KDAC), are epigenetic regulators that catalyze the removal of acetyl moieties from the tails of lysine residues of histones and other proteins. To date, eighteen HDAC family members (HDAC1-11 and SIRT1-7) have been identified and grouped into four classes according...

journal_title：Journal of the neurological sciences

authors： Li G,Jiang H,Chang M,Xie H,Hu L

更新日期：2011-05-15 00:00:00

abstract：:Recently an association between statins and the onset and more rapid disease course of amyotrophic lateral sclerosis (ALS) was reported, while other studies rejected such a link. The role of gender in that controversy is unclear. We evaluated the gender-specific effect of statins on the rate of functional decline in p...

journal_title：Journal of the neurological sciences

authors： Nefussy B,Hirsch J,Cudkowicz ME,Drory VE

更新日期：2011-01-15 00:00:00

abstract：BACKGROUND:Although a number of studies reported different interictal findings between migraine with aura (MA) and migraine without aura (MO), the pathophysiology of the visual aura in migraine remains unclear. OBJECTIVE:To investigate the visual processing in patients who experience MA between attacks using steady-st...

journal_title：Journal of the neurological sciences

authors： Shibata K,Yamane K,Otuka K,Iwata M

更新日期：2008-08-15 00:00:00

abstract：:Fatigue is a common symptom in patients with neurologic disease. Mechanisms of fatigue are still incompletely understood. In this paper, we review recent studies of fatigue in common neurologic conditions and discuss therapeutic interventions. In particular, the role of therapeutic exercise is examined in both health ...

journal_title：Journal of the neurological sciences

authors： Miller RG

更新日期：2006-03-15 00:00:00

abstract：:Thalamic damage is associated with a variety of neuropsychological dysfunctions, as well as strategic infarct dementia. However, only a limited number of reports in the medical literature have discussed the correlation between the clinical findings and the specific functional changes observed on images. We investigate...

journal_title：Journal of the neurological sciences

authors： Shim YS,Kim JS,Shon YM,Chung YA,Ahn KJ,Yang DW

更新日期：2008-03-15 00:00:00