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Aging and superoxide dismutase activity in cerebrospinal fluid.

Abstract：

:We investigated superoxide dismutase (SOD) activity in human cerebrospinal fluid (CSF) as an index of the aging process in the central nervous system (CNS). The subjects were 61 individuals aged 21-77 years, comprising 24 men and 37 women without organic disorders of the nervous system. SOD activity in CSF was measured by the nitrite method modified by Oyanagui. The results showed that SOD activity in CSF gradually increased with age and that the values of SOD activity after the fifth decade were significantly higher than those in the third and fourth decades. It might suggest that the productivity of SOD in the CNS gradually increased with age due to stimulation of various types of oxidative stress which accumulated in vivo especially after the fifth decade.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Okabe T,Hamaguchi K,Inafuku T,Hara M

doi

10.1016/0022-510x(96)00160-8

subject

Has Abstract

pub_date

1996-09-15 00:00:00

pages

100-4

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(96)00160-8

journal_volume

141

pub_type

杂志文章

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