Abstract:
BACKGROUND:Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that can be difficult to diagnose and distinguish from each other. STUDY AIMS AND METHODS: Patients with PD and MSA and controls were studied with magnetic resonance imaging (MRI) using tissue segmentation and outlining of regions in order to identify regional volume changes that might be useful in the diagnosis of the two diseases. RESULTS:Patients with PD had significantly larger intracranial volumes (ICVs) and significantly smaller putaminal and sustantia nigra volumes than controls. MSA patients had significantly smaller substantia nigra and caudate volumes than controls but normal intracranial volume. In both patient groups there was a further trend towards smaller amygdala volumes. DISCUSSION:Increased ICV in PD patients is a new finding that may be explained by genetic factors or compensatory responses to early CNS damage. Atrophy of the amygdala in MSA patients has not been demonstrated with MR before. It might explain why these patients can have hyposmia. The putaminal atrophy found in the PD group may be a trait of the later stages of PD. Segmentation of the substantia nigra can be a useful aid in the diagnosis of PD and MSA.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Krabbe K,Karlsborg M,Hansen A,Werdelin L,Mehlsen J,Larsson HB,Paulson OBdoi
10.1016/j.jns.2005.07.013subject
Has Abstractpub_date
2005-12-15 00:00:00pages
45-52issue
1eissn
0022-510Xissn
1878-5883pii
S0022-510X(05)00269-8journal_volume
239pub_type
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