Increased intracranial volume in Parkinson's disease.

Abstract:

BACKGROUND:Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that can be difficult to diagnose and distinguish from each other. STUDY AIMS AND METHODS: Patients with PD and MSA and controls were studied with magnetic resonance imaging (MRI) using tissue segmentation and outlining of regions in order to identify regional volume changes that might be useful in the diagnosis of the two diseases. RESULTS:Patients with PD had significantly larger intracranial volumes (ICVs) and significantly smaller putaminal and sustantia nigra volumes than controls. MSA patients had significantly smaller substantia nigra and caudate volumes than controls but normal intracranial volume. In both patient groups there was a further trend towards smaller amygdala volumes. DISCUSSION:Increased ICV in PD patients is a new finding that may be explained by genetic factors or compensatory responses to early CNS damage. Atrophy of the amygdala in MSA patients has not been demonstrated with MR before. It might explain why these patients can have hyposmia. The putaminal atrophy found in the PD group may be a trait of the later stages of PD. Segmentation of the substantia nigra can be a useful aid in the diagnosis of PD and MSA.

journal_name

J Neurol Sci

authors

Krabbe K,Karlsborg M,Hansen A,Werdelin L,Mehlsen J,Larsson HB,Paulson OB

doi

10.1016/j.jns.2005.07.013

subject

Has Abstract

pub_date

2005-12-15 00:00:00

pages

45-52

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(05)00269-8

journal_volume

239

pub_type

杂志文章
  • Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.

    abstract::Preclinical evidence strongly indicate that adenosine A(2A) receptor antagonists represent a promising class of drugs for the treatment of motor deficits associated to Parkinson's disease. The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomim...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2006.05.038

    authors: Simola N,Fenu S,Baraldi PG,Tabrizi MA,Morelli M

    更新日期:2006-10-25 00:00:00

  • Intrathecal synthesis of anti-HIV antibodies in AIDS patients.

    abstract::We studied the production within the CNS of anti-HIV antibodies, of non-specific IgG, and the presence of HIV antigens in the serum and CSF of 28 HIV infected patients belonging to group IV in the Center for Disease Control classification. CSF and serum were diluted under optimal conditions to equalize their IgG conte...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(90)90162-g

    authors: Lolli F,Colao MG,De Maio E,Di Pietro M,Galli E,Grippo A,Mazzotta F,Pinto F

    更新日期:1990-11-01 00:00:00

  • Concomitant administration of sodium dichloroacetate and thiamine in west syndrome caused by thiamine-responsive pyruvate dehydrogenase complex deficiency.

    abstract::We treated a female patient with West syndrome caused by thiamine-responsive pyruvate dehydrogenase complex (PDHC) deficiency. Infantile spasms occurred in association with elevated blood and CSF lactate concentrations; these symptoms disappeared when lactate concentrations had been lowered by treatment with concomita...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0022-510x(99)00250-6

    authors: Naito E,Ito M,Yokota I,Saijo T,Chen S,Maehara M,Kuroda Y

    更新日期:1999-12-01 00:00:00

  • Transient resolution of bilateral tremor after unilateral thalamotomy, associated with focal injury of the corpus callosum: case report.

    abstract::We present a patient with Parkinson's disease whose bilateral tremor transiently resolved after a unilateral left ventrolateral thalamotomy. The transient resolution of the bilateral tremor was associated with a focal thalamic lesion and a second lesion in the corpus callosum. The mechanism of this phenomenon may be r...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(94)00236-h

    authors: Greene KA,Wallace RC,Fram EK,Shetter AG,Lieberman AN

    更新日期:1995-03-01 00:00:00

  • Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.

    abstract:BACKGROUND:Natalizumab therapy reduces inflammation and degeneration of the CNS in relapsing-remitting multiple sclerosis (RRMS). In cerebrospinal fluid (CSF) the concentration of 24S-hydroxycholesterol (24OHC) reflect neurodegeneration, whereas 27-hydroxycholesterol (27OHC) is dependent on the integrity of the blood-b...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.08.1537

    authors: Novakova L,Axelsson M,Malmeström C,Zetterberg H,Björkhem I,Karrenbauer VD,Lycke J

    更新日期:2015-11-15 00:00:00

  • The clinical and pathological phenotypes of frontotemporal dementia with C9ORF72 mutations.

    abstract::An expanded hexanucleotide repeat in the chromosome 9 open reading frame 72 (C9ORF72), on chromosome 9p21, has recently been identified as a major cause of familial frontotemporal dementia (FTD). The neuropathology and clinical characteristics associated with C9ORF72 mutations are heterogeneous with the unknown pathom...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2013.09.013

    authors: Liu Y,Yu JT,Sun FR,Ou JR,Qu SB,Tan L

    更新日期:2013-12-15 00:00:00

  • Diffusion-weighted imaging in Wallerian degeneration.

    abstract::We report two patients displaying hyperintensities on diffusion-weighted imaging (DWI) in the area of Wallerian degeneration (WD) at 12 days after stroke. High signal intensities were more conspicuous on DWI than on T2-weighted images. Both patients showed decreased diffusion anisotropy resulting in elevated apparent ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(00)00373-7

    authors: Kang DW,Chu K,Yoon BW,Song IC,Chang KH,Roh JK

    更新日期:2000-09-15 00:00:00

  • How long does it take to diagnose cervical dystonia?

    abstract:BACKGROUND:Dystonia is a neurological disorder characterized by involuntary twisting movements and postures. The neck is among the most commonly affected regions, and diagnosis can be made readily through a simple clinical evaluation. The goal of this study was to explore how long it took patients to receive a diagnosi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2013.08.028

    authors: Tiderington E,Goodman EM,Rosen AR,Hapner ER,Johns MM 3rd,Evatt ML,Freeman A,Factor S,Jinnah HA

    更新日期:2013-12-15 00:00:00

  • Immune regulation within the central nervous system.

    abstract::The brain constitutes an environment that is specifically designed to accommodate, regulate and shape immune responses. On one hand, the central nervous system (CNS) has traditionally been regarded as an immunologically privileged organ, owing to local tissue barrier and immunosuppressive microenvironment. On the othe...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0022-510x(98)00049-5

    authors: Xiao BG,Link H

    更新日期:1998-04-15 00:00:00

  • Neuropathology of sporadic amyotrophic lateral sclerosis of long duration.

    abstract::We performed post-mortem examinations of three patients with progressive neurogenic amyotrophy of long duration. One patient had been clinically diagnosed as having sporadic amyotrophic lateral sclerosis (ALS) and two had been diagnosed with progressive spinal muscular atrophy (PSMA). The disease durations were 10, 17...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(96)00297-3

    authors: Iwanaga K,Hayashi S,Oyake M,Horikawa Y,Hayashi T,Wakabayashi M,Kondo H,Tsuji S,Takahashi H

    更新日期:1997-03-10 00:00:00

  • Deletions of mitochondrial DNA in Kearns-Sayre syndrome and ocular myopathies: genetic, biochemical and morphological studies.

    abstract::Genetic, biochemical and morphological investigations were conducted on skeletal muscle mitochondria from 6 cases of ocular myopathy: 4 cases with Kearns-Sayre syndrome (KSS) and 2 with chronic progressive external ophthalmoplegia. All of these 6 cases showed mitochondrial DNA (mtDNA) deletions in addition to normal s...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(91)90042-6

    authors: Degoul F,Nelson I,Lestienne P,Francois D,Romero N,Duboc D,Eymard B,Fardeau M,Ponsot G,Paturneau-Jouas M

    更新日期:1991-02-01 00:00:00

  • Ingested (oral) anti-IL-12/23 inhibits EAE.

    abstract:BACKGROUND:Blocking the activity of IL-12/23 can inhibit autoimmune diseases such as psoriasis. OBJECTIVE:We examined whether an antibody against IL-12/23, ustekinumab (UTZ) (Stelera®), used clinically in psoriasis would have similar anti-inflammatory effects in EAE after oral administration. DESIGN/METHODS:B6 mice w...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.12.011

    authors: Brod SA

    更新日期:2016-02-15 00:00:00

  • The presence of autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptor in the blood serum of patients with epilepsy.

    abstract::We have analyzed the serum from patients with refractory epilepsy for the presence of autoreactive antibodies to AMPA glutamate receptor subunits. The presence and the level of autoantibodies were assessed using immunoblot and ELISA with synthetic peptides specific for subregions of AMPA glutamate receptor subunits. P...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(97)00150-0

    authors: Dambinova SA,Izykenova GA,Burov SV,Grigorenko EV,Gromov SA

    更新日期:1997-11-06 00:00:00

  • Insulin resistance in amyotrophic lateral sclerosis.

    abstract::Over the last 30 years glucose intolerance has been reported in a significant percentage of patients with amyotrophic lateral sclerosis (ALS). Currently, a controversy exists in determining whether the carbohydrate abnormality is disease-specific or secondary to decreased glucose utilization due to muscle atrophy. A r...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(84)90154-0

    authors: Reyes ET,Perurena OH,Festoff BW,Jorgensen R,Moore WV

    更新日期:1984-03-01 00:00:00

  • Overlap of Guillain-Barre syndrome and Bickerstaff's brainstem encephalitis.

    abstract::The nosological relationship between Bickerstaff s brainstem encephalitis (BBE) and Guillain-Barre syndrome (GBS) has yet to be clarified. We report results of the autopsy of a patient for whom overlapping BBE and GBS was diagnosed clinically. This and similar cases support the original authors' hypothesis that BBE is...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(96)00251-1

    authors: Yuki N,Wakabayashi K,Yamada M,Seki K

    更新日期:1997-01-01 00:00:00

  • Burden of non-motor symptoms in unclear parkinsonism and tremor: A study with [123I]FP-CIT SPECT.

    abstract:BACKGROUND:Non-motor symptoms (NMSs) are clearly more prevalent in Parkinson's disease (PD) patients compared to healthy individuals. However, NMSs are also common in the elderly and other neurological conditions, and thus, it is not known whether NMSs could be used to differentiate PD from parkinsonism/tremor without ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2019.07.025

    authors: Jaakkola E,Joutsa J,Mäkinen E,Noponen T,Pitkonen M,Levo R,Mertsalmi T,Scheperjans F,Kaasinen V

    更新日期:2019-09-15 00:00:00

  • Delay in the maturation of muscle fibers in infants with congenital hypotonia.

    abstract::Muscle biopsies of hypotonic children have shown delayed maturation of a fetal type of muscle fibers: subsarcolemmal halo devoid of activity for mitochondrial dehydrogenases, type II predominance and in some cases abnormal dispersion of fiber diameter. Fiber subtypes within group II were also abnormal. One case has de...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(78)90184-3

    authors: Farkas-Bargeton E,Aicardi J,Arsenio-Nunes ML,Wehrle R

    更新日期:1978-11-01 00:00:00

  • Factors influencing a patient's decision regarding riluzole: an early experience.

    abstract::Riluzole is the first drug to be approved in the United States for the treatment of amyotrophic lateral sclerosis (ALS). During the first 8 months of the drug's availability by prescription, its use was discussed with 46 patients with probable or definite ALS as defined by the E1 Escorial criteria. Seventeen of the pa...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0022-510x(97)00250-5

    authors: Rudnicki SA

    更新日期:1997-10-01 00:00:00

  • Effects of successive repetitive transcranial magnetic stimulation on motor performances and brain perfusion in idiopathic Parkinson's disease.

    abstract::We studied the effects of 0.2 Hz repetitive transcranial magnetic stimulation (rTMS) successively performed 6 times for 2 weeks in 12 patients with idiopathic Parkinson's disease (PD). Ten patients received rTMS to the bilateral frontal cortex (frontal rTMS) and six patients received rTMS to the bilateral occipital co...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0022-510x(02)00459-8

    authors: Ikeguchi M,Touge T,Nishiyama Y,Takeuchi H,Kuriyama S,Ohkawa M

    更新日期:2003-05-15 00:00:00

  • Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients.

    abstract:BACKGROUND:Hypertensive (HT) patients are at higher risk of cognitive decline than normotensive individuals, because high blood pressure is a risk factor for mild cognitive deterioration. In this study cardio- and cerebrovascular reactivity along with cognitive performance was assessed on newly diagnosed HT patients. ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2010.07.022

    authors: Kovács KR,Szekeres CC,Bajkó Z,Csapó K,Molnár S,Oláh L,Magyar MT,Bereczki D,Kardos L,Soltész P,Bojtor AB,Csiba L

    更新日期:2010-12-15 00:00:00

  • Altered resting state functional network connectivity in children absence epilepsy.

    abstract::Altered functional connectivity has been associated with the influence of epileptic activity. Abnormalities in connectivity, particularly in dorsal attention (DAN), salience (SN) and default mode (DMN) networks, might contribute to the loss of consciousness during seizures and cognitive deficits in patients with child...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.04.054

    authors: Li Q,Cao W,Liao X,Chen Z,Yang T,Gong Q,Zhou D,Luo C,Yao D

    更新日期:2015-07-15 00:00:00

  • Immunofluorescence studies in a case of rheumatoid neuropathy.

    abstract::Findings in a sural nerve biopsy from a patient with rheumatoid neuropathy are reported. Inflammatory changes in different stages were observed in epineurial arterioles. Arterioles with fibrinoid necrosis contained IgG, IgM, rheumatoid factor and complement. The same substances were found at the inner site of the peri...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(77)90128-9

    authors: Van Lis JM,Jennekens FG

    更新日期:1977-09-01 00:00:00

  • Changes in risk factors and preventive treatments by stroke subtypes over 20 years: a population-based study.

    abstract::In order to evaluate progress in preventive therapeutic strategies, and to identify potential targets for improvement, it is essential to assess changes in the risk factors and preventive treatment of stroke over time. All of the strokes occurring within the population of Dijon, France (150,000 inhabitants), were pros...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2009.08.062

    authors: Béjot Y,Osseby GV,Gremeaux V,Durier J,Rouaud O,Moreau T,Giroud M

    更新日期:2009-12-15 00:00:00

  • Environmental factors and their regulation of immunity in multiple sclerosis.

    abstract::Epidemiological and clinical studies have shown that environmental factors such as infections, smoking and vitamin D are associated with the risk of developing multiple sclerosis (MS). Some of these factors also play a role in the MS disease course. We are currently beginning to understand how environmental factors ma...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2012.10.021

    authors: Koch MW,Metz LM,Agrawal SM,Yong VW

    更新日期:2013-01-15 00:00:00

  • Combination of myotonic dystrophy and hereditary motor and sensory neuropathy.

    abstract::Myotonic Dystrophy Type 1 (DM1) in combination with demyelinating neuropathy is very rare in literature. In this study, DM1 and demyelinating neuropathy were demonstrated clinically and electromyographically in a 43-year-old female patient from Turkey. In the patient an expanded CTG repeat in the Myotonic Dystrophy Pr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2009.09.028

    authors: Kurt S,Karaer H,Kaplan Y,Akat I,Battaloglu E,Eruslu D,Basak AN

    更新日期:2010-01-15 00:00:00

  • A single report of hemiplegic arm stretching related to yawning: further investigation using apomorphine administration.

    abstract::We observed a stroke patient with an infarct of the internal capsule interrupting the pyramidal tract who stretched his hemiplegic arm during spontaneous and apomorphine-induced yawning. The putative mechanism by which yawning can induce the paradoxical motor response of the plegic arm in the patient might be the func...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(94)90278-x

    authors: Blin O,Rascol O,Azulay JP,Serratrice G,Nieoullon A

    更新日期:1994-11-01 00:00:00

  • Bradykinesia in early and advanced Parkinson's disease.

    abstract:BACKGROUND:Motor impairment in Parkinson's disease (PD) includes slowness (bradykinesia), decreased amplitude (hypokinesia), impaired rhythm and a progressive reduction in speed and amplitude during movement repetition (sequence effect). In the present study we aimed to analyse bradykinesia features in newly-diagnosed ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2016.08.028

    authors: Bologna M,Leodori G,Stirpe P,Paparella G,Colella D,Belvisi D,Fasano A,Fabbrini G,Berardelli A

    更新日期:2016-10-15 00:00:00

  • Correlation of impaired subjective visual vertical and postural instability in Parkinson's disease.

    abstract::Perception of verticality is essential for postural control. On the other hand, postural instability is one of the cardinal features in Parkinson's disease (PD). Thus, the objective of this study was to evaluate the vertical perception using the subjective visual vertical test in PD patients with different degrees of ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2014.07.057

    authors: Pereira CB,Kanashiro AK,Maia FM,Barbosa ER

    更新日期:2014-11-15 00:00:00

  • CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.

    abstract::In five patients with cerebral manifestation of Wilson's disease, copper was measured in CSF, serum, urine and liver, and ceruloplasmin was determined in CSF and serum. CSF copper was found to be elevated in all cases, especially in the four examined before therapy. Two patients were followed up for a period of 3 year...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(87)90275-9

    authors: Weisner B,Hartard C,Dieu C

    更新日期:1987-06-01 00:00:00

  • Depression in Tourette syndrome: A controlled and comparison study.

    abstract:BACKGROUND:Tourette syndrome (TS) is a neurodevelopmental condition characterised by multiple tics and co-morbid behavioural problems. Previous research found that up to 76% of patients with TS experience affective symptoms, with 13% fulfilling diagnostic criteria for depression. OBJECTIVES:We aimed to assess the seve...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jns.2016.03.030

    authors: Piedad JC,Cavanna AE

    更新日期:2016-05-15 00:00:00