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Glial fibrillary acidic protein (GFAP): purification from human fibrillary astrocytoma, development and validation of a radioimmunoassay for GFAP-like immunoactivity.

Abstract：

:The extraction and purification of glial fibrillary acidic protein (GFAP) from human fibrillary cerebellar astrocytoma is described. Using an immunoperoxidase method, antisera raised to the protein showed specific staining of astrocytes in normal spinal cord and in tumours of astrocytic origin. A double antibody radioimmunoassay for GFAP in tissue extract was developed, the detection limit of the assay being 360 pg. Extracts of tissues other than brain or spinal cord did not cross-react significantly in the assay, neither did purified preparations of myelin basic and S-100 proteins. Levels of GFAP in normal CNS tissue were higest in spinal cord (1370 microgram/g wet weight) but a level of 3050 microgram/g wet weight was detected in a fibrillary astrocytoma.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Palfreyman JW,Thomas DG,Ratcliffe JG,Graham DI

doi

10.1016/0022-510x(79)90144-8

subject

Has Abstract

pub_date

1979-03-01 00:00:00

pages

101-13

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(79)90144-8

journal_volume

41

pub_type

杂志文章

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