Abstract:
BACKGROUND:Botulinum toxin A (BTA) responders have elevated levels of calcitonin gene-related and vasoactive intestinal peptides, which are potent vasodilators. We aimed to investigate neurovascular features as a predictor of BTA treatment response in patients with chronic migraine. METHODS:We prospectively recruited South Korean patients who were diagnosed with chronic migraine and underwent BTA injection at a university hospital from December 2013 to January 2015. Interictal transcranial Doppler (TCD) test was performed before BTA treatment when patients did not experience moderate-to-severe headache attacks. Botulinum toxin A was injected per the Phase III REsearch Evaluating Migraine Prophylaxis Therapy (PREEMPT) protocol. Treatment response was determined after 4-6 weeks of follow-up. Pretreatment clinical and neurosonologic features of responders and non-responders were analyzed. RESULTS:Of the 83 enrolled patients, 70 who completed initial and follow-up evaluations were included for this study. Forty-two (60.0%) patients were classified as responders. 50% responders were 31 (44.2%). Longer disease duration was associated with poor treatment outcome (p=0.019). The ratio of the mean velocity of middle cerebral artery to that of ipsilateral internal carotid artery (MCA/ICA index) was significantly higher in responders than non-responders (p=0.027) and remained significant after controlling for covariates (p=0.025). CONCLUSIONS:Shorter disease duration and higher pretreatment MCA/ICA index on TCD are associated with good early outcomes of BTA treatment.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Lee MJ,Lee C,Choi H,Chung CSdoi
10.1016/j.jns.2016.01.054subject
Has Abstractpub_date
2016-04-15 00:00:00pages
51-4eissn
0022-510Xissn
1878-5883pii
S0022-510X(16)30054-5journal_volume
363pub_type
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
pub_type: 临床试验,杂志文章
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2013.02.010
更新日期:2013-05-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2006.05.006
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2015.05.012
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.jns.2013.01.035
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2010.10.014
更新日期:2011-02-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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更新日期:1999-12-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.jns.2015.06.032
更新日期:2015-09-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.jns.2013.02.011
更新日期:2013-05-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(78)90251-4
更新日期:1978-08-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2008.12.019
更新日期:2009-07-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/s0022-510x(02)00428-8
更新日期:2003-02-15 00:00:00
abstract:OBJECTIVES:We hypothesize that the regional pattern of blood flow reduction in the brain is different between tremor-dominant Parkinson's disease (PD) and postural instability gait difficulty (PIGD)-dominant PD. We therefore investigated the association of phenotypes in untreated PD with brain perfusion on SPECT using ...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2005.10.017
更新日期:2006-02-15 00:00:00
abstract::In boys with Duchenne muscular dystrophy (DMD) plasma myoglobin levels remained approximately constant with age while creatine kinase (CK) activity progressively decreased. For carrier detection, plasma myoglobin level was found to be less reliable than CK activity. The myoglobin level was raised only in some of those...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(84)90194-1
更新日期:1984-02-01 00:00:00