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Myasthenia due to carnitine treatment.

Abstract：

:Severe weakness of lower cranial and girdle muscles has been found in 4 subjects among 20 dialysis patients treated with carnitine in order to correct their high plasma triglyceride level. Neurophysiological investigation showed an impairment of neuromuscular transmission with short-term reduction of evoked muscle responses to repetitive stimulation and the presence of "post-activation exhaustion phenomenon" 3 min after the train. Both the weakness and the neurophysiological findings were less pronounced after edrophonium. These findings suggest a hemicholinium activity of carnitine at synaptic level.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

De Grandis D,Mezzina C,Fiaschi A,Pinelli P,Bazzato G,Morachiello M

doi

10.1016/0022-510x(80)90061-1

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

365-71

issue

3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(80)90061-1

journal_volume

46

pub_type

杂志文章

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