Abstract：
:The presence of postural disturbance in patients with Parkinson's disease (PD) was assessed by the displacement of the centre of foot pressure (CFP) and by changes in the amplitude of the soleus H-reflex when patients maintained an upright standing posture, followed by a forward-leaning posture. Thirteen patients and 13 age-matched normal controls (N) were studied. PD patients showed the following differences when compared to normal subjects: (1) the range of displacement of the CFP associated with forward leaning was significantly smaller (P<0.01); (2) the ratio of the increase in the soleus EMG activity to the CFP displacement (deltaEMG/deltaCFP) was larger (P<0.01), and the value of the deltaEMG/deltaCFP increased significantly in relation to the scale of clinical severity (P<0.01); and (3) the ratio of the increase in the amplitude of the soleus H-reflex to the soleus muscle EMG activity (deltaH-reflex/deltaEMG) was significantly lower in PD patients (P<0.05). The value of the deltaH-reflex/deltaEMG decreased significantly with the scale of clinical severity among the patients (P<0.05). These results suggest that the modulation of both the tonic stretch reflex and the phasic stretch reflex in the soleus muscle during standing are impaired in PD patients, and these impairments may partly cause their disability in the maintenance of a standing posture. Abnormalities in Ib inhibition and presynaptic inhibition are considered to be possible mechanisms in the disturbed modulation of the tonic stretch reflex and the phasic stretch reflex in PD patients during standing.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Hayashi R,Tokuda T,Tako K,Yanagisawa Ndoi
10.1016/s0022-510x(97)00175-5subject
Has Abstractpub_date
1997-12-09 00:00:00pages
61-7issue
1eissn
0022-510Xissn
1878-5883pii
S0022510X97001755journal_volume
153pub_type
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