当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Comparison of major cortical aminopeptidase activity in normal brain and brain from patients with Alzheimer's disease.

Comparison of major cortical aminopeptidase activity in normal brain and brain from patients with Alzheimer's disease.

Abstract：

:In order to develop a greater understanding of the importance of peptide catabolism in the intracellular protein degradation process in normal and pathological human brain, we have undertaken a systematic investigation of the aminopeptidase group of enzymes. Although a wide range of aminoacyl-7-amino-4-methylcoumarin derivatives (which are used to measure aminopeptidase activity) were hydrolysed by normal human cortical soluble extract, fractionation of the latter via anion exchange and gel filtration chromatography resolved only 4 separable aminopeptidase types (activity relative to alanyl aminopeptidase in parenthesis): alanyl (EC 3.4.11.14, 100%); arginyl (2 isoenzymes, EC 3.4.11.6, 15%); pyroglutamyl (EC 3.4.19.3, 4%); and leucyl (EC 3.4.11.1, 1%). Thus approx. 80% of the total soluble aminopeptidase activity in normal human cerebral cortex can be accounted for by a single enzyme, the major cortical aminopeptidase. The activity of this enzyme was measured in the soluble fraction prepared from 4 cortical regions (occipital, frontal, temporal and parietal) in a series of 8 patients with Alzheimer's disease and compared with corresponding data in 8 control normal patients. Although enzyme activity varied in these cortical regions, the activity in corresponding brain areas in the Alzheimer's disease and normal groups was very similar. These findings suggest that the characteristic neurodegeneration associated with Alzheimer's disease does not result from altered activity of the major cortical aminopeptidase in the cortical tissue of patients with this disorder.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Mantle D,Lauffart B,Perry EK,Perry RH

doi

10.1016/0022-510x(89)90024-5

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

227-34

issue

2-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(89)90024-5

journal_volume

89

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Further studies of mitochondrial and lipid storage myopathies.

    abstract：:Further observations on a family with facioscapulohumeral (FSH) muscular dystrophy due to mitochondrial myopathy, and on a case with lipid storage myopathy are reported. One member of the family with FSH muscular dystrophy died due to a viral pneumonia, during which she developed gross hyperlacticacidaemia and acidosi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90003-5

    authors： Bradley WG,Tomlinson BE,Hardy M

    更新日期：1978-02-01 00:00:00

  • Cerebrovascular reactivity after treatment of unruptured intracranial aneurysms--A transcranial Doppler sonography and acetazolamide study.

    abstract：BACKGROUND:Cerebrovascular reactivity (CVR) is defined as the change in cerebral blood flow, or blood velocity, in response to a vasoactive stimulus. There is a possible association between impaired CVR and vasospasm after aneurysmal subarachnoid hemorrhage. Most studies on CVR and vasospasm have used healthy subjects ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.12.024

    authors： Bøthun ML,Haaland ØA,Logallo N,Svendsen F,Thomassen L,Helland CA

    更新日期：2016-04-15 00:00:00

  • Peripheral neuropathy in HIV patients on antiretroviral therapy: Does it impact function?

    abstract：:HIV-associated distal sensory polyneuropathy (DSP), with or without neuropathic symptoms, can develop after anti-retroviral therapy (ART). Symptoms frequently involve small fibres but reports on autonomic dysfunction in HIV-DSP are sparse. We studied an HIV-infected cohort after 5 years of ART, and report on the frequ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116451

    authors： Dudley MT,Borkum M,Basera W,Wearne N,Heckmann JM

    更新日期：2019-11-15 00:00:00

  • Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody.

    abstract：:Anti-Yo antibodies are present in the sera and cerebrospinal fluid of some patients with paraneoplastic cerebellar degeneration (PCD), but there is no evidence that the presence of anti-Yo antibodies causes the Purkinje cell loss seen in PCD patients. We examined the level of cytotoxic T lymphocyte (CTL) activity agai...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00163-x

    authors： Tanaka M,Tanaka K,Tokiguchi S,Shinozawa K,Tsuji S

    更新日期：1999-09-15 00:00:00

  • Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders.

    abstract：:The mitochondria have several important functions in the cell. A mitochondrial dysfunction causes an abatement in ATP production, oxidative damage and the induction of apoptosis, all of which are involved in the pathogenesis of numerous disorders. This review focuses on mitochondrial dysfunctions and discusses their c...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2007.01.033

    authors： Sas K,Robotka H,Toldi J,Vécsei L

    更新日期：2007-06-15 00:00:00

  • Over ten years overall survival in glioblastoma: A different disease?

    abstract：PURPOSE:The reasons why a specific subset of glioblastoma (GBM) patients survive longer than others is still unclear. This study analyzed a cohort of long-term and very-long-term GBM survivors to determine which genetic alterations or patient's characteristics influence survival time. METHODS:We retrospectively review...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116518

    authors： Marton E,Giordan E,Siddi F,Curzi C,Canova G,Scarpa B,Guerriero A,Rossi S,D' Avella D,Longatti P,Feletti A

    更新日期：2020-01-15 00:00:00

  • Brainstem auditory evoked potential (BAEP) abnormalities in brucellosis.

    abstract：:Twelve patients with neurobrucellosis and 17 patients with systemic brucellosis without neurological involvement underwent a brainstem auditory evoked potentials (BAEP) study. All neurobrucellosis patients (100%) showed abnormalities in their BAEP recordings, suggestive of brainstem lesions at various levels. On the o...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90255-9

    authors： Khuraibet AJ,Shakir RA,Trontelj JV,Butinar D,al-Din AS

    更新日期：1988-11-01 00:00:00

  • High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study.

    abstract：:High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are ver...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00297-6

    authors： Assaf Y,Mayzel-Oreg O,Gigi A,Ben-Bashat D,Mordohovitch M,Verchovsky R,Reider-Groswasser II,Hendler T,Graif M,Cohen Y,Korczyn AD

    更新日期：2002-11-15 00:00:00

  • Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency.

    abstract：:3G11, a sialylated carbohydrate epitope on the disialoganglioside molecule, is expressed predominantly on the surface of mouse CD4(+) T cells. Our previous studies suggested that lack of the 3G11 molecule could be a new cell surface marker for regulatory CD4(+) T cells. In the present study, we explore the relationshi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.04.019

    authors： Zhao Z,Ciric B,Yu S,Li H,Yang J,Kamoun M,Zhang GX,Rostami A

    更新日期：2010-08-15 00:00:00

  • Effect of immunotherapy in myelitis with atopic diathesis.

    abstract：OBJECTIVE:A recent nationwide survey of myelitis with atopic diathesis in Japan disclosed that the disease frequently shows a chronic persistent course. A neuropathological study of the spinal cord also revealed chronic active inflammation. Since the effects of various immunotherapies have not been studied extensively ...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jns.2004.08.001

    authors： Murai H,Arahata H,Osoegawa M,Ochi H,Minohara M,Taniwaki T,Tobimatsu S,Mihara F,Tsuruta Y,Inaba S,Kira J

    更新日期：2004-12-15 00:00:00

  • Insulin resistance in amyotrophic lateral sclerosis.

    abstract：:Over the last 30 years glucose intolerance has been reported in a significant percentage of patients with amyotrophic lateral sclerosis (ALS). Currently, a controversy exists in determining whether the carbohydrate abnormality is disease-specific or secondary to decreased glucose utilization due to muscle atrophy. A r...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90154-0

    authors： Reyes ET,Perurena OH,Festoff BW,Jorgensen R,Moore WV

    更新日期：1984-03-01 00:00:00

  • Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease.

    abstract：:In addition to neuritic changes and amyloid deposits, neuronal and glial cell apoptosis is an important pathological feature of Alzheimer's disease (AD). Several factors have been postulated as causes or triggers of cellular apoptotic change. This study focused on a quantifiable relationship between phosphorylation si...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00410-0

    authors： Kobayashi K,Nakano H,Hayashi M,Shimazaki M,Fukutani Y,Sasaki K,Sugimori K,Koshino Y

    更新日期：2003-04-15 00:00:00

  • Effect of mild cognitive impairment on balance.

    abstract：OBJECTIVE:To investigate the effect of mild cognitive impairment (MCI) on balance. METHODS:87 subjects with subjective memory impairment were enrolled, and subdivided into two groups, MCI and non-MCI, according to diagnostic criteria of amnestic subtype of MCI according to the 1999 MCI international panel (Current Con...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.02.031

    authors： Shin BM,Han SJ,Jung JH,Kim JE,Fregni F

    更新日期：2011-06-15 00:00:00

  • Mirror movements in Parkinson's disease: An under-appreciated clinical sign.

    abstract：INTRODUCTION:Mirror movements (MM) have been previously reported in patients with Parkinson's disease (PD). Despite being potentially relevant in PD, MM as a neurological sign have remained less recognized. In this study we critically evaluated the characteristic features of MM and their attributes among a cohort of PD...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.05.026

    authors： Chatterjee P,Banerjee R,Choudhury S,Mondal B,Kulsum MU,Chatterjee K,Kumar H

    更新日期：2016-07-15 00:00:00

  • Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: A proof-of-concept study.

    abstract：BACKGROUND:ew drugs were confirmed to be effective in the treatments of neurological dysfunction caused by acute intracerebral hemorrhage (ICH). The present prospective clinical trial aims to evaluate the effect of mouse nerve growth factor (mNGF) on neurological function in patients with acute ICH. METHODS:60 patient...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.117069

    authors： An S,Jia Y,Tian Y,Sun J,Wei Y,Yue S,Lin L,Wei Y,Li Y,Lei P,Zhang J,Jiang R

    更新日期：2020-11-15 00:00:00

  • Distribution of intramembranous particle size in the muscle plasma membrane of the mdx mouse.

    abstract：:We investigated whether the reduced intramembranous particles (IMP) in the muscle plasma membrane in mdx mice reflects a preferential depletion of a particular size of the IMP. The experiments were performed using the freeze-fracture method to analyze the frequency distribution of the size of IMP, the density of ortho...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)05350-6

    authors： Ito H,Yoshimura T,Tsujihata M,Nagataki S

    更新日期：1997-05-29 00:00:00

  • Increased cathepsin B activity in multiple sclerosis brain.

    abstract：:Cathepsin B (CB) activity was measured in aqueous extracts of frozen autopsy specimens of centrum semiovale from three MS patients, five control patients with other neurological diseases, and five normal individuals. Mean activity was significantly increased in the MS tissue compared with controls. The mean activity i...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(95)00039-5

    authors： Bever CT Jr,Garver DW

    更新日期：1995-07-01 00:00:00

  • Reciprocal expression of dystrophin and utrophin in muscles of Duchenne muscular dystrophy patients, female DMD-carriers and control subjects.

    abstract：:We examined muscle biopsies from patients with Duchenne muscular dystrophy (DMD: 39 patients) and Becker muscular dystrophy (BMD: 11 patients), female DMD-carriers (4 patients), and control subjects (26 persons) for the expression of dystrophin and utrophin. Control subjects showed all fibers to be dystrophin-positive...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90190-a

    authors： Mizuno Y,Nonaka I,Hirai S,Ozawa E

    更新日期：1993-10-01 00:00:00

  • Single dose of methylphenidate improves cognitive performance in multiple sclerosis patients with impaired attention process.

    abstract：BACKGROUND AND PURPOSE:Attention is one of the major cognitive domains adversely affected in multiple sclerosis (MS). The aim of the current study was to determine the effect of a single dose of methylphenidate on cognitive performance of MS patients with significant attention deficit. METHODS:In a double-blind placeb...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jns.2008.08.025

    authors： Harel Y,Appleboim N,Lavie M,Achiron A

    更新日期：2009-01-15 00:00:00

  • Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel.

    abstract：:High plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and stroke and Alzheimer's disease (AD). An inverse relationship has been reported between tHcy and plasma B12 and folate levels. Seventy-nine AD patients and 156 controls from three Arab villages in northern Israel participated. Plasma tHcy, ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2004.08.011

    authors： Mizrahi EH,Bowirrat A,Jacobsen DW,Korczyn AD,Traore F,Petot GJ,Lerner AJ,Debanne SM,Adunsky A,Dibello PM,Friedland RP

    更新日期：2004-12-15 00:00:00

  • Mutational analysis of TARDBP gene in patients affected by Parkinson's disease from Calabria.

    abstract：OBJECTIVE:Neurodegenerative diseases are often characterized by the presence of intracellular or extracellular protein aggregates in the central nervous system. Mutations of TARDBP gene have been shown to cause Amyotrophic Lateral Sclerosis and have been reported to present with clinical heterogeneity including parkins...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2018.04.043

    authors： Gagliardi M,Arabia G,Nisticò R,Iannello G,Procopio R,Manfredini L,Annesi G,Quattrone A

    更新日期：2018-07-15 00:00:00

  • CaMKII antisense oligodeoxynucleotides protect against ischemia-induced neuronal death in the rat hippocampus.

    abstract：:The present study was performed to investigate the effects of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) antisense oligodeoxynucleotides (ODNs) on the assembly of the CaMKII·GluR6·PSD-95 signaling module, GluR6 serine phosphorylation and c-Jun N-terminal kinase 3 (JNK3) activation. A further aim was to det...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.10.012

    authors： Liu Z,Xu J,Shen X,Lv C,Xu T,Pei D

    更新日期：2012-03-15 00:00:00

  • Intravascular lymphomatosis presenting with sudden hearing loss.

    abstract：:Intravascular lymphoma (IVL) is a rare disorder characterized by the aggregation of malignant large cell lymphoma cells in small vessels. Neurological manifestations are typically the initial and, often the only, clinically obvious consequences of this malignancy. Diagnosis is dependent on biopsy or postmortem demonst...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2005.01.001

    authors： Berger JR,Jones R,Wilson D

    更新日期：2005-05-15 00:00:00

  • Determinants of cognitive disorders in Autosomal Dominant Cerebellar Ataxia type 1.

    abstract：:We assessed neuropsychological performances of 22 patients affected by Autosomal Dominant Cerebellar Ataxia type 1. All subjects completed a comprehensive battery of standardized tests requiring a verbal response, without time constraints. In order to verify the hypothesis that disease severity is the major factor in ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(98)00070-7

    authors： Trojano L,Chiacchio L,Grossi D,Pisacreta AI,Calabrese O,Castaldo I,De Michele G,Filla A

    更新日期：1998-05-07 00:00:00

  • Primary angiitis of the central nervous system: report of eight cases from a single Italian center.

    abstract：:The primary angiitis of the central nervous system (PACNS) is a rare and potentially fatal form of vasculitis with unknown etiology. Headache and encephalopathy are the most frequent symptoms. Neuroimaging plays an important role in the diagnosis, but the pattern of abnormal findings is not specific. In some cases bra...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.05.014

    authors： Pizzanelli C,Catarsi E,Pelliccia V,Cosottini M,Pesaresi I,Puglioli M,Moretti P,Tavoni A

    更新日期：2011-08-15 00:00:00

  • Roentgenmorphological aspects of muscular pseudohypertrophy.

    abstract：:Using special soft tissue X-ray investigations the authors have found that the increase in volume of the calf musculature in progressive muscular dystrophy does not seem to be in complete accordance with the criteria of pseudohypertrophy. It has been demonstrated that this structural alteration of the musculature does...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90074-1

    authors： Pálvölgyi R,Gallai M

    更新日期：1979-09-01 00:00:00

  • Longitudinal course of mild parkinsonian signs in elderly people: A population-based study in Japan.

    abstract：:We aimed to clarify the longitudinal course of mild parkinsonian signs (MPS) and their association with dementia and functional disability by conducting a comprehensive epidemiological study, including brain MRI, and assessments of cognition, depression, and sleep, in people aged ≥65years living in Ama-cho. We diagnos...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.01.016

    authors： Wada-Isoe K,Tanaka K,Uemura Y,Nakashita S,Tajiri Y,Tagashira S,Yamamoto M,Yamawaki M,Kishi M,Nakashima K

    更新日期：2016-03-15 00:00:00

  • Relation between MRI features and dementia in cerebrovascular disease patients with leukoaraiosis: a longitudinal study.

    abstract：:We examined selective MRI features (localization and degree of white matter abnormalities, cortical and subcortical atrophy) in relation to cognitive decline in patients with cerebrovascular disease (CVD) and leukoaraiosis (LA). We enrolled 6 female and 18 male CVD patients (mean age 66.2 +/- 6.6 years) whose Magnetic...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90263-x

    authors： Bracco L,Campani D,Baratti E,Lippi A,Inzitari D,Pracucci G,Amaducci L

    更新日期：1993-12-15 00:00:00

  • More than hemifacial spasm? A case of unilateral facial spasms with systematic review of red flags.

    abstract：:Unilateral facial spasms (UFS) are frequently caused by hemifacial spasm (HFS), a disorder that usually results from vascular loop compression at the root exit zone of the facial nerve. However, UFS can also be a manifestation of other conditions, including brainstem tumours or demyelination, post-Bell's synkinesis, l...

    journal_title：Journal of the neurological sciences

    pub_type： 信件

    doi：10.1016/j.jns.2019.116532

    authors： Sringean J,Dressler D,Bhidayasiri R

    更新日期：2019-12-15 00:00:00

  • Muscle pathology of myotonia congenita.

    abstract：:We have investigated the muscle biopsies of 8 patients with myotonia congenita. There were 2 families with autosomal recessive inheritance (5 cases), 1 with autosomal dominant inheritance, and 2 sporadic cases. Mild abnormalities were seen with routine pathological preparations which were nondiagnostic. Histochemical ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(76)90116-7

    authors： Crews J,Kaiser KK,Brooke MH

    更新日期：1976-08-01 00:00:00