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Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency.

Abstract：

:3G11, a sialylated carbohydrate epitope on the disialoganglioside molecule, is expressed predominantly on the surface of mouse CD4(+) T cells. Our previous studies suggested that lack of the 3G11 molecule could be a new cell surface marker for regulatory CD4(+) T cells. In the present study, we explore the relationship between 3G11(-) and CD25(+) T cells, a well-defined, naturally occurring regulatory T cell population. We found that a large proportion of CD25(+)CD4(+) T cells lack expression of 3G11 and that more 3G11(-)CD4(+) T cells express Foxp3 compared to the 3G11(+)CD4(+) population. Based on 3G11 and CD25 expression we sorted four CD4(+) T cell subpopulations and tested their phenotypes. Among four CD25/3G11-related CD4(+) T cell subpopulations, CD25(+)3G11(-) T cells expressed the highest levels of Foxp3 and IL-10 and most efficiently inhibited mitogenic and antigen-specific immune responses in vitro and clinical EAE in vivo, while CD25(-)3G11(+) T cells produced a higher level of proinflammatory cytokines and enhanced autoimmune responses. Thus, among CD4(+)CD25(+) T cells, CD25(+)3G11(-) T cells represent a more effective Treg subpopulation than CD25(+)3G11(+) T cells.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Zhao Z,Ciric B,Yu S,Li H,Yang J,Kamoun M,Zhang GX,Rostami A

doi

10.1016/j.jns.2010.04.019

subject

Has Abstract

pub_date

2010-08-15 00:00:00

pages

66-74

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(10)00201-7

journal_volume

295

pub_type

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