Abstract:
PURPOSE:To evaluate the clinical implications of status epilepticus in patients with metastases to the brain as well as associated demographic, clinical, EEG and radiographic features. METHODS:Retrospective chart review of 19 patients with metastases to the brain who subsequently developed status epilepticus. RESULTS:Of the patients who developed status epilepticus only 36.8% had a prior history of seizures since diagnosis of brain metastases. Status epilepticus most commonly occurred in the setting of a new structural injury to the brain such as new metastases, increase in size of metastases or hemorrhage. 57.9% of patients had either refractory or super-refractory status epilepticus. Focal non-convulsive status epilepticus was the most common subtype occurring in 42.1% of patients. 31.6% of patients died within 30 days of the onset of status epilepticus. CONCLUSION:Status epilepticus eventually resolved with treatment in all patients with brain metastases; however, it is associated with poor outcomes as nearly one-third was deceased within 30-days of onset. Nevertheless, no patients died during status epilepticus. Thus, status epilepticus may be indicative of an overall poor clinical status among patients with brain metastases.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Fox J,Ajinkya S,Greenblatt A,Houston P,Lekoubou A,Lindhorst S,Cachia D,Olar A,Kutluay Edoi
10.1016/j.jns.2019.116538subject
Has Abstractpub_date
2019-12-15 00:00:00pages
116538eissn
0022-510Xissn
1878-5883pii
S0022-510X(19)30881-0journal_volume
407pub_type
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