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An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study.

Abstract：

OBJECTIVE:The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. METHODS:In a cross-sectional population sample of 1751 people (age 40-84 years, 46.4% men), we used an automated method to segment WMH using T1-weighted and T2-weighted fluid-attenuated inversion recovery image obtained at 3T. CoW variants were classified from time-of-flight scans, also at 3T. WMH risk factors, including age, sex, smoking and blood pressure, were obtained from questionnaires and clinical examinations. We used linear regression to examine whether people with incomplete CoW variants had greater volumes of deep WMH (DWMH) and periventricular WMH (PWMH) compared to people with the complete CoW, correcting for WMH risk factors. RESULTS:Participants with incomplete CoW variants did not have significantly higher DWMH or PWMH volumes than those with complete CoW when accounting for risk factors. Age, pack-years smoking, and systolic blood pressure were risk factors for increased DWMH and PWMH volume. Diabetes was a unique risk factor for increased PWMH volume. CONCLUSION:Incomplete CoW variants do not appear to be risk factors for WMH in the general population.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Hindenes LB,Håberg AK,Mathiesen EB,Vangberg TR

doi

10.1016/j.jns.2020.117268

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

117268

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(20)30604-3

journal_volume

420

pub_type

杂志文章

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