当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis.

Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis.

Abstract：

:Predicting clinical outcome is one of the major and most interesting issues in MS patients. If the global evolution of disability (usually chosen levels on the Kurtzke's Disability Status Scale) has been widely studied, much less is known about the progression of disability during the secondary progressive phase of the disease. It is usually said that there is a poorer prognosis once patients enter a progressive phase, whether from onset (like in primary progressive MS) or after an initial relapsing-remitting phase. The secondary progressive phase of multiple sclerosis (MS) is the one most often associated with the development of severe and irreversible disability. Despite this fact, there is a lot of information about the initial relapsing-remitting phase in the literature, but much less about the secondary progressive one. We review here information available from the literature and from the Lyon MS database about this secondary progressive phase.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Vukusic S,Confavreux C

doi

10.1016/s0022-510x(02)00426-4

subject

Has Abstract

pub_date

2003-02-15 00:00:00

pages

135-7

issue

2

eissn

0022-510X

issn

1878-5883

pii

S0022510X02004264

journal_volume

206

pub_type

杂志文章,评审

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Familial bulbo-spinal muscular atrophy associated with testicular atrophy and sensory neuropathy (Kennedy-Alter-Sung syndrome). Autopsy case report of two brothers.

    abstract：:Autopsy cases of two brothers with bulbo-spinal muscular atrophy associated with gynecomastia, testicular atrophy and sensory neuropathy are reported. The disease started with finger tremor, proximal muscle weakness and facial muscle twitching at the second and fourth decades, accompanied by bulbar signs and glove-sto...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90240-7

    authors： Nagashima T,Seko K,Hirose K,Mannen T,Yoshimura S,Arima R,Nagashima K,Morimatsu Y

    更新日期：1988-11-01 00:00:00

  • Methylprednisolone increases dystrophin levels by inhibiting myotube death during myogenesis of normal human muscle in vitro.

    abstract：:The glucocorticoid methylprednisolone (Mepd) increased dystrophin and myosin heavy chain levels in differentiated cultures of cloned human myoblasts. Mepd increased the number of myotubes per area by preventing myotube death and detachment during myogenesis in vitro. Myotube death was the result of an endogenous proce...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90019-4

    authors： Sklar RM,Brown RH Jr

    更新日期：1991-01-01 00:00:00

  • Autonomic dysfunction in different subtypes of post-acute ischemic stroke.

    abstract：OBJECTIVES:Central autonomic impairment is frequent in ischemic stroke at acute or chronic stages. The mechanism by which these symptoms occur in patients with ischemic stroke has not been elucidated. This study sought to investigate cardiovascular autonomic function in patients with different subtypes of post-acute is...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.11.036

    authors： Xiong L,Leung HW,Chen XY,Leung WH,Soo OY,Wong KS

    更新日期：2014-02-15 00:00:00

  • 5'-flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan.

    abstract：:Though the etiology of Parkinson's disease (PD) is unresolved and may be heterogeneous involving both environmental and genetic factors, there are indications that oxidative stress plays an important role in dopaminergic neuronal death. And, it has been reported that inhibition of nitric oxide synthase (NOS) can preve...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00666-9

    authors： Lo HS,Hogan EL,Soong BW

    更新日期：2002-02-15 00:00:00

  • Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?

    abstract：:Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, but not migraine atta...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90160-3

    authors： Ferrari MD,Odink J,Frölich M,Tapparelli C,Portielje JE

    更新日期：1989-10-01 00:00:00

  • Peroneal muscular atrophy. Part 2. Nerve biopsy studies.

    abstract：:The present study used the nerve pathology, studied by quantitative light microscopy, as the sole basis for classification of peroneal muscular atrophy (PMA). The findings in biopsies of superficial peroneal nerves of 20 patients were compared with normal values obtained from 8 controls. Three homogeneous groups compr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(83)90173-9

    authors： Gherardi R,Bouché P,Escourolle R,Hauw JJ

    更新日期：1983-10-01 00:00:00

  • A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack.

    abstract：:The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we performed a systematic review of randomized controlled trials (RCTs) to investigate whether PFO closure was superior to medical th...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2013.11.027

    authors： Chen L,Luo S,Yan L,Zhao W

    更新日期：2014-02-15 00:00:00

  • Repair of N-methylpurines in DNA from lymphocytes of patients with amyotrophic lateral sclerosis.

    abstract：:We have previously reported reduced ability of ALS fibroblasts to repair genomic DNA damage produced by alkylating agents. This report presents our experience of studying DNA repair in lymphocytes from ALS patients. The repair of N-methylpurines produced by treatment with the alkylating agent, methyl methanesulfonate,...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90225-n

    authors： Robison SH,Tandan R,Bradley WG

    更新日期：1993-04-01 00:00:00

  • Symptomatic orthostatic hypotension in Parkinson's disease patients: Prevalence, associated factors and its impact on balance confidence.

    abstract：BACKGROUND:Orthostatic hypotension (OH) is a commonly reported sign of the cardiovascular autonomic dysfunctions associated with Parkinson's disease (PD). Patients might suffer from a variety of the clinical symptoms of OH, including dizziness, lightheadedness, or problems with vision and fatigue. OBJECTIVES:To determ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.12.037

    authors： Klanbut S,Phattanarudee S,Wongwiwatthananukit S,Suthisisang C,Bhidayasiri R

    更新日期：2018-02-15 00:00:00

  • Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients.

    abstract：BACKGROUND:Hypertensive (HT) patients are at higher risk of cognitive decline than normotensive individuals, because high blood pressure is a risk factor for mild cognitive deterioration. In this study cardio- and cerebrovascular reactivity along with cognitive performance was assessed on newly diagnosed HT patients. ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.07.022

    authors： Kovács KR,Szekeres CC,Bajkó Z,Csapó K,Molnár S,Oláh L,Magyar MT,Bereczki D,Kardos L,Soltész P,Bojtor AB,Csiba L

    更新日期：2010-12-15 00:00:00

  • Comparison of hemihypoglossal- and accessory-facial neurorrhaphy for treating facial paralysis in rats.

    abstract：:The aim of this study was to determine the effectiveness of hypoglossal-facial nerve "side"-to-end (HemiHN-FN) and accessory-facial nerve end-to-end (AN-FN) neurorrhaphy using a predegenerated nerve graft (PNG) for reanimating facial paralysis in a rat FN injury model. A total of 25 rats with complete unilateral facia...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.10.006

    authors： Li D,Wan H,Feng J,Wang S,Su D,Hao S,Schumacher M,Liu S

    更新日期：2014-12-15 00:00:00

  • Combined treatment with LDL-apheresis, chenodeoxycholic acid and HMG-CoA reductase inhibitor for cerebrotendinous xanthomatosis.

    abstract：:The effects of combined treatment with low-density lipoprotein (LDL)-apheresis, chenodeoxycholic acid (CDCA) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor were studied in 2 patients with cerebrotendinous xanthomatosis. Patient 1 was initially treated with LDL-apheresis alone: serum cholestanol level...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jns.2003.07.005

    authors： Ito S,Kuwabara S,Sakakibara R,Oki T,Arai H,Oda S,Hattori T

    更新日期：2003-12-15 00:00:00

  • Myasthenia gravis with a monoclonal gammopathy--report of a case.

    abstract：:An elderly man with relapsing myasthenia gravis was found to have hypergammaglobulinaemia, a monoclonal peak of gamma mobility and paraproteinaemia IgG, type K. Bence-Jones proteinuria, type K was present. This is the fourth report of myasthenia gravis associated with a monoclonal gammopathy. Myasthenia gravis is cons...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(80)80011-6

    authors： Galli M,Landi G,Restelli DL,Scarlato G

    更新日期：1980-02-01 00:00:00

  • Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation.

    abstract：:Cortical excitability to magnetic stimulation was investigated interictally in 10 patients with migraine with aura, 10 with migraine without aura and in 10 healthy volunteers. Thresholds, latencies and amplitudes of the magnetic-evoked potentials (MEPs) were measured from threshold to 100% stimulus intensity in 10% st...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)00044-5

    authors： van der Kamp W,Maassen VanDenBrink A,Ferrari MD,van Dijk JG

    更新日期：1996-07-01 00:00:00

  • Hemispheric differences in malignant middle cerebral artery stroke.

    abstract：BACKGROUND:We recently reported that left versus right hemisphere cerebral infarctions patients more frequently have worse outcomes. However our clinical experience led us to suspect that the incidence of malignant middle cerebral artery infarctions (MMCA) was higher in the right compared to the left hemispheric stroke...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2015.04.036

    authors： Rastogi V,Lamb DG,Williamson JB,Stead TS,Penumudi R,Bidari S,Ganti L,Heilman KM,Hedna VS

    更新日期：2015-01-01 00:00:00

  • Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing.

    abstract：:The analysis of human skeletal muscle mitochondria revealed a progressive decline in mitochondrial respiratory chain function with age. The activities affected to the greatest extent were those of complexes I and IV which were decreased by 59% and 47% respectively between the ages of 20-30 years and 60-90 years of age...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90270-u

    authors： Cooper JM,Mann VM,Schapira AH

    更新日期：1992-11-01 00:00:00

  • Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat.

    abstract：:A nitric oxide releasing compound, NOC-18, was injected intrathecally in order to determine the role of NO in spinal nociceptive mechanisms in rats. The nociceptive threshold was evaluated by the radiant heat tail-flick test. The effects of intrathecal injection of N-nitro-L-arginine methyl ester (L-NAME), an NO synth...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00188-3

    authors： Inoue T,Mashimo T,Shibuta S,Yoshiya I

    更新日期：1997-12-09 00:00:00

  • CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.

    abstract：:In five patients with cerebral manifestation of Wilson's disease, copper was measured in CSF, serum, urine and liver, and ceruloplasmin was determined in CSF and serum. CSF copper was found to be elevated in all cases, especially in the four examined before therapy. Two patients were followed up for a period of 3 year...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(87)90275-9

    authors： Weisner B,Hartard C,Dieu C

    更新日期：1987-06-01 00:00:00

  • Absence of neuronal and glial proteins in human and rat leptomeninges in situ.

    abstract：:Human leptomeningeal (arachnoid and pia mater) cells in culture have been demonstrated in replicated studies to express typical neuronal proteins such as neurofilament protein and neuron-specific enolase. In addition, they can express glial fibrillary acidic protein. The present study examines the possibility that neu...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)00189-x

    authors： Calingasan NY,Bernstein JJ,Blass JP

    更新日期：1996-12-01 00:00:00

  • Comparison of gamma-glutamyl transpeptidase activity in tissues of normal and dystrophic hamsters and mice.

    abstract：:The activity of gamma-glutamyl transpeptidase (gamma-GT), a membrane-bound enzyme, was assayed by a sensitive fluorometric method in the brain, heart, kidney, liver, skeletal muscle and serum of normal and dystrophic hamsters and mice. Normal and dystrophic hamsters were of the golden brown and BIO 14.6 line respectiv...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(77)90130-7

    authors： Neerunjun JS,Dubowitz V

    更新日期：1977-09-01 00:00:00

  • N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease.

    abstract：:The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptor that is involved in synaptic mechanisms of learning and memory, and mediates excitotoxic neuronal injury. In this study, we tested the hypothesis that NMDA receptor subunit gene expression is altered in Alzheimer's disease (AD), esp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00087-4

    authors： Bi H,Sze CI

    更新日期：2002-08-15 00:00:00

  • Clinical and neuroimaging features of the m.10197G>A mtDNA mutation: New case reports and expansion of the phenotype variability.

    abstract：:Complex I (CI) is the largest component of the mitochondrial respiratory chain (MRC) and it is made up of 7 mitochondrial DNA (mtDNA)-encoded and at least 38 nuclear DNA-encoded subunits. Isolated CI deficiency is the most common single enzyme deficiency in the heterogeneous group of MRC disorders and it is a relative...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.02.010

    authors： Tolomeo D,Rubegni A,Severino M,Pochiero F,Bruno C,Cassandrini D,Madeo A,Doccini S,Pedemonte M,Rossi A,D'Amore F,Donati MA,Di Rocco M,Santorelli FM,Nesti C

    更新日期：2019-04-15 00:00:00

  • Increasing and persistent DWI changes in a patient with hereditary diffuse leukoencephalopathy with spheroids.

    abstract：:We report a case with genetically confirmed hereditary diffuse leukoencephalopathy with spheroids with distinctive MRI features. A 52-year-old woman with a family history of juvenile dementia presented with an 18-month history of progressive cognitive decline. Longitudinal magnetic resonance imaging studies of the bra...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.08.027

    authors： Terasawa Y,Osaki Y,Kawarai T,Sugimoto T,Orlacchio A,Abe T,Izumi Y,Kaji R

    更新日期：2013-12-15 00:00:00

  • Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system.

    abstract：:Mice were inoculated with herpes simplex virus (HSV) type 1 by gently scraping the skin of the nose with a fine needle. About 80% of the animals developed latent inapparent HSV infections in trigeminal ganglia. Virus was demonstrable for at least 6 months post inoculation (p.i.) by cocultivation of ganglionic tissue w...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90119-9

    authors： Kristensson K,Svennerholm B,Persson L,Vahlne A,Lycke E

    更新日期：1979-10-01 00:00:00

  • Assessment of 'on-treatment platelet reactivity' and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis.

    abstract：INTRODUCTION:The relationship between on-treatment platelet reactivity and cerebral micro-embolic signals (MES) is unknown, and has not been previously simultaneously assessed in asymptomatic and symptomatic carotid stenosis patients. METHODS:Consecutive eligible patients with ≥50% asymptomatic or recently symptomatic...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.03.015

    authors： Kinsella JA,Oliver Tobin W,Tierney S,Feeley TM,Egan B,Coughlan T,Ronan Collins D,O'Neill D,Harbison JA,Doherty CP,Madhavan P,Moore DJ,O'Neill SM,Colgan MP,Saqqur M,Murphy RP,Moran N,Hamilton G,McCabe DJH

    更新日期：2017-05-15 00:00:00

  • Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia.

    abstract：OBJECT:The purpose of this study was to determine the effects of diazoxide on apoptosis and the relative mechanisms in a model of brain injury induced by cerebral ischemia/reperfusion (I/R) during deep hypothermia. METHODS:Three-week-old Sprague-Dawley male rats were randomly and equitably divided into sham-operated g...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.10.029

    authors： He X,Mo X,Gu H,Chen F,Gu Q,Peng W,Qi J,Shen L,Sun J,Zhang R,Kj Y

    更新日期：2008-05-15 00:00:00

  • The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status.

    abstract：:We have monitored the cell surface phenotypic changes occurring in T, B and NK cells of chronic progressive multiple sclerosis (MS) patients after total lymphoid irradiation (TLI) plus low-dose prednisone (TLI-LDP) therapy in comparison to sham TLI-LDP. TLI-LDP resulted in a marked reduction in the relative and absolu...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0022-510x(97)00156-1

    authors： Rohowsky-Kochan C,Molinaro D,Devereux C,Troiano R,Bansil S,Zito G,Wolansky L,Jotkowitz A,Denny T,Oleske J,Dowling P,Cook SD

    更新日期：1997-11-25 00:00:00

  • Prevalence of migraine headache and its weight on neurological burden in Africa: a 43-year systematic review and meta-analysis of community-based studies.

    abstract：BACKGROUND:Headache burden is not adequately explored in Africa. Here, we measured weighted migraine prevalence from community-based studies in Africa. METHODS:PubMed search was employed using terms 'headache in Africa' AND/OR 'migraine in Africa' for published literature from 1970 until January 31, 2014. PRISMA was a...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jns.2014.04.019

    authors： Woldeamanuel YW,Andreou AP,Cowan RP

    更新日期：2014-07-15 00:00:00

  • Studies of resistance to ischemic nerve conduction failure in normal and diabetic rats.

    abstract：:Increased resistance to ischemic nerve conduction failure (RINCF) has been demonstrated in the spontaneously diabetic BB Wistar rat as well as in non-insulin dependent but hyperglycemic litter-mates. There is marked variability in the severity of the ischemic resistance in insulin dependent rats but not in the non-ins...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90161-5

    authors： Parry GJ,Kohzu H

    更新日期：1989-10-01 00:00:00

  • A case of 3243A>G mutation in mtDNA presenting as apparently idiopathic hyperCKemia.

    abstract：:The 3243A>G mutation of mtDNA usually is associated with MELAS syndrome. Here we report a patient with the 3243A>G mutation presenting only recurrent muscle fatigue and elevated levels of serum creatine kinase (CK). The mother of the proband was referred to us for type 2 diabetes mellitus, muscle pain and sensorineura...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.01.010

    authors： Rubegni A,Cardaioli E,Chini E,Da Pozzo P,Battisti C,Malandrini A,Federico A

    更新日期：2014-03-15 00:00:00