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High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study.

Abstract：

:High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are very common in VaD as well as in other types of dementia. Therefore, the role of white matter changes in the cognitive and memory decline that occurs in VaD patients is still under debate. High-b DWI, analyzed using the q-space approach, is a more sensitive MRI method for detection of white matter changes. High-b DWI revealed massive white matter loss in VaD patients that surpassed the boundaries of T2 hyperintensities. This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Assaf Y,Mayzel-Oreg O,Gigi A,Ben-Bashat D,Mordohovitch M,Verchovsky R,Reider-Groswasser II,Hendler T,Graif M,Cohen Y,Korczyn AD

doi

10.1016/s0022-510x(02)00297-6

subject

Has Abstract

pub_date

2002-11-15 00:00:00

pages

235-9

eissn

0022-510X

issn

1878-5883

pii

S0022510X02002976

journal_volume

203-204

pub_type

杂志文章

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