Abstract:
:Degeneration at the neuromuscular function following cutting the phrenic nerve at the 9th intercostal space differs in red, white and intermediate skeletal muscle fibers. The ultrastructure of the nerve terminal and the muscle fiber between 12 hours and 21 days following denervation suggests that lack of neurotrophic influences results in responses specific for each fiber type. Degeneration of axon ends is rapid and by 2 days axon terminals are missing from the end-plate areas of all 3 fiber types. Schwann cells "engulf" degenerating axon terminals and eventually replace them in the primary clefts. Schwann cells display specific morphological changes directly related to axonal degeneration. In all instances axon terminal degeneration precedes muscle fiber degeneration. Synaptic cleft changes are similar for all types of muscle fibers. Primary cleft structure appears to be dependent upon neurotrophic influence, whereas secondary cleft structure is relatively unaffected by denervation. Initial changes in subsynpatic regions of muscle fibers include focal loss of sarcomere alignment and skewing of the Z lines. By 21 days myofibrillar disorganization appears most severe in white fibers and least in red muscle fibers. The rate and degree of degeneration of the axon terminal and subjacent muscle fiber are different for each of the 3 muscle fiber types.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Pulliam DL,April EWdoi
10.1016/0022-510x(79)90116-3subject
Has Abstractpub_date
1979-10-01 00:00:00pages
205-22issue
2eissn
0022-510Xissn
1878-5883pii
0022-510X(79)90116-3journal_volume
43pub_type
杂志文章abstract:BACKGROUND:ew drugs were confirmed to be effective in the treatments of neurological dysfunction caused by acute intracerebral hemorrhage (ICH). The present prospective clinical trial aims to evaluate the effect of mouse nerve growth factor (mNGF) on neurological function in patients with acute ICH. METHODS:60 patient...
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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doi:10.1016/0022-510x(75)90140-9
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journal_title:Journal of the neurological sciences
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journal_title:Journal of the neurological sciences
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doi:10.1016/j.jns.2014.04.009
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journal_title:Journal of the neurological sciences
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doi:10.1016/j.jns.2009.04.037
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journal_title:Journal of the neurological sciences
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doi:10.1016/j.jns.2016.09.025
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journal_title:Journal of the neurological sciences
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更新日期:1999-12-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2009.11.015
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journal_title:Journal of the neurological sciences
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更新日期:1994-11-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
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更新日期:1997-02-27 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(79)90096-0
更新日期:1979-05-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/s0022-510x(98)00050-1
更新日期:1998-04-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2010.12.011
更新日期:2011-03-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(76)90171-4
更新日期:1976-10-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.jns.2020.116952
更新日期:2020-08-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(96)00112-8
更新日期:1996-09-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
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更新日期:2007-03-15 00:00:00
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journal_title:Journal of the neurological sciences
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doi:10.1016/j.jns.2015.06.048
更新日期:2015-09-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(79)90074-1
更新日期:1979-09-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2004.06.012
更新日期:2004-09-15 00:00:00
abstract::Identification of the Negri bodies in the brain of an 8-year-old boy who died 8 days after a paralytic illness and 20 days after a dog bite, and who had received 9 injections of Semple's anti-rabies vaccine, provided evidence that he died of acute rabies encephalitis and not of post-vaccinal allergic encephalomyelitis...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(86)90093-6
更新日期:1986-09-01 00:00:00
abstract::We report a case with genetically confirmed hereditary diffuse leukoencephalopathy with spheroids with distinctive MRI features. A 52-year-old woman with a family history of juvenile dementia presented with an 18-month history of progressive cognitive decline. Longitudinal magnetic resonance imaging studies of the bra...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2013.08.027
更新日期:2013-12-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2007.12.017
更新日期:2008-06-15 00:00:00
abstract::The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN), 3-hydroxykynurenine (3-HK) and picolinic acid (PIC). The former two are neuroactive, while the latter two are molecules with pro-oxidants an...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.jns.2012.08.005
更新日期:2012-12-15 00:00:00
abstract::Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had ne...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2011.07.010
更新日期:2011-11-15 00:00:00
abstract::Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for neuromyelitis optica (NMO). However, the molecular mechanism of NMO still remains unclear. The purpose of this study was to identify the possible humoral mechanisms responsible for the occurrence of astrocytic damage. Human prima...
journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2013.05.035
更新日期:2013-08-15 00:00:00