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Pleomorphism of fine structure of rabies virus in human and experimental brain.

Abstract：

:Identification of the Negri bodies in the brain of an 8-year-old boy who died 8 days after a paralytic illness and 20 days after a dog bite, and who had received 9 injections of Semple's anti-rabies vaccine, provided evidence that he died of acute rabies encephalitis and not of post-vaccinal allergic encephalomyelitis. The Negri bodies in the human subject and those seen in the inoculated mouse differed in their morphological structure: the former consisted of a matrix of very fine granular material bearing larger granules or strands of higher electron-density resembling nucleic acids and representing products of host cell-virus interaction; and the latter showed better defined areas of granular matrix containing tubular, bullet-shaped and elongated forms of viral structures, and nucleocapsids or capsule-deficient cores, representing the virions, emerging from them. Fine structural examination of the patient's brain and of the inoculated mouse has provided evidence of the pleomorphism of the Negri bodies and the various stages of formation of viral material and virions in them, the animal alone showing the mature virions of rabies, and proving the infectivity of the Negri bodies of the human brain.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Manghani DK,Dastur DK,Nanavaty AN,Patel R

doi

10.1016/0022-510x(86)90093-6

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

181-93

issue

2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(86)90093-6

journal_volume

75

pub_type

杂志文章

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