Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?


:Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, but not migraine attack-free plasma, released Met-enkephalin from platelets of migraineurs. Platelets of healthy controls or tension headache sufferers did not release their Met-enkephalin in response to either incubation medium. In contrast to Met-enkephalin, serotonin was not released from platelets in relevant quantities by migraine-attack plasma.


J Neurol Sci


Ferrari MD,Odink J,Frölich M,Tapparelli C,Portielje JE




Has Abstract


1989-10-01 00:00:00














  • Myasthenic crisis: guidelines for prevention and treatment.

    abstract::Management of myasthenic crisis (MC) requires admission of the patient into a neurological intensive care unit and timely institution of an efficient and safe treatment. Despite the growing clinical experience with disease modifying immunotherapy there is no clinical consensus regarding the use of plasma exchange or h...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Jani-Acsadi A,Lisak RP

    更新日期:2007-10-15 00:00:00

  • Familial Creutzfeldt-Jakob disease.

    abstract::A Finnish family is described with 9 cases of presenile dementia in 3 generations. The mean age at onset was 52 years (range 46--62 years). Progressive dementia, upper motor neuron signs, muscular rigidity, and twitching, irregular tremors were consistent features in the 6 clinically investigated patients and were ass...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Haltia M,Kovanen J,Van Crevel H,Bots GT,Stefanko S

    更新日期:1979-08-01 00:00:00

  • Increased intracranial volume in Parkinson's disease.

    abstract:BACKGROUND:Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that can be difficult to diagnose and distinguish from each other. STUDY AIMS AND METHODS: Patients with PD and MSA and controls were studied with magnetic resonance imaging (MRI) using tissue segmentation and outlining...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Krabbe K,Karlsborg M,Hansen A,Werdelin L,Mehlsen J,Larsson HB,Paulson OB

    更新日期:2005-12-15 00:00:00

  • The diagnostic value of plasma myoglobin levels in the adult and fetus at-risk for Duchenne muscular dystrophy.

    abstract::In boys with Duchenne muscular dystrophy (DMD) plasma myoglobin levels remained approximately constant with age while creatine kinase (CK) activity progressively decreased. For carrier detection, plasma myoglobin level was found to be less reliable than CK activity. The myoglobin level was raised only in some of those...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Edwards RJ,Rodeck CH,Watts DC

    更新日期:1984-02-01 00:00:00

  • Subacute perihematomal edema in intracerebral hemorrhage is associated with impaired blood pressure regulation.

    abstract:BACKGROUND:Perihematomal edema and secondary brain injury may influence the clinical course after intracerebral hemorrhage (ICH). The role of blood pressure (BP) in edema formation in ICH has not been studied sufficiently. We hypothesize that impaired blood pressure regulation (as measured by baroreflex sensitivity) le...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Sykora M,Diedler J,Turcani P,Rupp A,Steiner T

    更新日期:2009-09-15 00:00:00

  • The nosology of tardive syndromes.

    abstract::Since the original description of side effects of neuroleptics, different terminologies and definitions for tardive dyskinesia (TD) and tardive syndrome (TS) have been used by different authors, and often these two terms have been used interchangeably. This paper proposes a nosology designed to define and clarify vari...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Frei K,Truong DD,Fahn S,Jankovic J,Hauser RA

    更新日期:2018-06-15 00:00:00

  • Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia.

    abstract::The relationship between dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) has been insufficiently described, and it is still problematic. Twenty-nine cases of DLB and 10 cases of PDD were investigated in the present study. DLB cases disclosed a significantly older disease onset and shorter d...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Horimoto Y,Matsumoto M,Nakazawa H,Yuasa H,Morishita M,Akatsu H,Ikari H,Yamamoto T,Kosaka K

    更新日期:2003-12-15 00:00:00

  • Cognitive fatigue in multiple sclerosis: findings from a two-wave screening project.

    abstract:BACKGROUND:Multiple sclerosis (MS) patients commonly suffer from fatigue and define it as one of their most disabling symptom profoundly disrupting their lives. However, the relationship of fatigue to cognitive functions and its impact on quality of life have not been widely studied. AIM:To define (1) "cognitive fatig...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Barak Y,Achiron A

    更新日期:2006-06-15 00:00:00

  • Parabiotic reinnervation in normal and dystrophic mice. Part 2. Morphological studies.

    abstract::The technique of parabiotic reinnervation has been used to test directly the neurogenic theory of the aetiology of muscular dystrophy in mice. Dystrophic muscles contain significantly fewer muscle fibres than their normal controls; they also have a much broader spectrum of fibre size because of a much higher proportio...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Johnson MA,Montgomery A

    更新日期:1975-11-01 00:00:00

  • Bilateral striatal necrosis caused by a founder mitochondrial 14459G>A mutation in two independent Japanese families.

    abstract::Bilateral striatal necrosis (BSN) has many causes and is characterized by unique clinical and neuroradiological features. Herein, we report a clinical and genetic analysis of three BSN cases from two independent Japanese families harboring a mitochondrial DNA (mtDNA) 14459G>A mutation located in a coding region of the...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hirayanagi K,Okamoto Y,Takai E,Ishizawa K,Makioka K,Fujita Y,Kaneko Y,Tanaka M,Takashima H,Ikeda Y

    更新日期:2017-07-15 00:00:00

  • Natural course of LGI1 encephalitis: 3-5 years of follow-up without immunotherapy.

    abstract::Antibodies against LGI1 (leucin-rich glioma-inactivated 1 protein) are associated with limbic encephalitis (LE), which is characterized by a favorable outcome following immunotherapy. Here, we present two cases, where antibodies against LGI1 were detected in the sera 36 and 53 months after acute LE, respectively, and ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Szots M,Marton A,Kover F,Kiss T,Berki T,Nagy F,Illes Z

    更新日期:2014-08-15 00:00:00

  • The significance of cerebral atrophy for the symptomatology of Parkinson's disease.

    abstract::Hitherto published results on the impact of brain atrophy on the neurological and psychopathological sympion of this problem without risk of complications. We investigated 173 parkinsonian patients (89 men, 84 women) aged 37--83 years. Besides CT in all patients a standardized neurological and psychopathological inves...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Schneider E,Fischer PA,Jacobi P,Becker H,Hacker H

    更新日期:1979-07-01 00:00:00

  • Clinical characteristics and outcomes of myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis in varying age groups: A cohort study in China.

    abstract:PURPOSE:To investigate the clinical characteristics and outcomes of myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis (MOG-ON) in patients with varying ages of onset in China. METHODS:Patients displaying symptoms of MOG-ON were recruited from the Neuro-ophthalmology Department in the Chinese Peo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Song H,Zhou H,Yang M,Xu Q,Sun M,Wei S

    更新日期:2019-05-15 00:00:00

  • Nurse led telephone assessment of expanded disability status scale assessment in MS patients at high levels of disability.

    abstract:BACKGROUND:In clinical trials drop out bias reduces the validity of results. This is a particular problem in long-term multiple sclerosis (MS) studies, particularly when patients become progressively disabled and have increasing difficulty attending assessment clinics. OBJECTIVE:To assess the validity of nurse led tel...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究


    authors: Huda S,Cavey A,Izat A,Mattison P,Boggild M,Palace J

    更新日期:2016-03-15 00:00:00

  • International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. The Ataxia Neuropharmacology Committee of the World Federation of Neurology.

    abstract::Despite the involvement of cerebellar ataxia in a large variety of conditions and its frequent association with other neurological symptoms, the quantification of the specific core of the cerebellar syndrome is possible and useful in Neurology. Recent studies have shown that cerebellar ataxia might be sensitive to var...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Trouillas P,Takayanagi T,Hallett M,Currier RD,Subramony SH,Wessel K,Bryer A,Diener HC,Massaquoi S,Gomez CM,Coutinho P,Ben Hamida M,Campanella G,Filla A,Schut L,Timann D,Honnorat J,Nighoghossian N,Manyam B

    更新日期:1997-02-12 00:00:00

  • Prevalence and subtypes of dementia in southern Taiwan: impact of age, sex, education, and urbanization.

    abstract::To determine the prevalence and subtypes of dementia in southern Taiwan, a two-phase study consisting of a phase I screening survey using the Mini-Mental Status Examination (MMSE) and a phase II diagnostic examination using the CERAD neuropsychological battery and the neurobehavioral examination was conducted. Accordi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Lin RT,Lai CL,Tai CT,Liu CK,Yen YY,Howng SL

    更新日期:1998-09-18 00:00:00

  • Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils.

    abstract::Nitric oxide (*NO)-mediated toxicity has been involved in neurodegenerative diseases, including Parkinson's disease (PD). We have recently reported an increase of about 50% in *NO production rate in PMA-activated polymorphonuclear leukocytes (PMN) from either newly diagnosed or chronically treated PD patients. As humo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Gatto EM,Riobó NA,Carreras MC,Schöpfer FJ,Pargament GA,Poderoso JJ

    更新日期:1999-05-01 00:00:00

  • Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings.

    abstract::Pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS), is an autosomal recessive neurodegenerative disorder characterized by iron accumulation in the brain. Mutations in the pantothenate kinase 2 (PANK2) gene are known to be responsible for PKAN. Several studies h...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Doi H,Koyano S,Miyatake S,Matsumoto N,Kameda T,Tomita A,Miyaji Y,Suzuki Y,Sawaishi Y,Kuroiwa Y

    更新日期:2010-03-15 00:00:00

  • Evoked potential measures of auditory cortical function and auditory comprehension in aphasia.

    abstract::This study investigated the relation between severity of auditory comprehension impairment in aphasia and the functional integrity of the posterior superior temporal region as evaluated by middle- and long-latency auditory evoked potentials and dipole source analysis. AEPs were studied in 20 stroke patients and in age...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Praamstra P,Stegeman DF,Kooijman S,Moleman J

    更新日期:1993-03-01 00:00:00

  • Long-term follow-up of patients with adult-onset subacute sclerosing panencephalitis.

    abstract::Subacute sclerosing panencephalitis (SSPE) is a rare infectious central nervous system disease with a poor prognosis. Nineteen patients, 18 males and one female, ranging in age from 18 to 22, mean 19.6+/-1.5 years with SSPE were evaluated. We treated 9 patients with oral isoprinosine and 10 patients with alpha-interfe...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章


    authors: Eroglu E,Gokcil Z,Bek S,Ulas UH,Ozdag MF,Odabasi Z

    更新日期:2008-12-15 00:00:00

  • Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy.

    abstract::There is ample evidence of an important role of descending serotonergic projections in modulating spinal motor neuron activation and firing, and experimental studies suggest that 5-HT receptor stimulation can improve motor function after spinal cord injury; however, relevant clinical data is sorely lacking. We describ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Horvath GA,Meisner L,Selby K,Stowe R,Carleton B

    更新日期:2017-07-15 00:00:00

  • The characteristics of spinal imaging in different types of demyelinating diseases.

    abstract:BACKGROUND:Transverse myelitis is the common presentation in demyelinating conditions. OBJECTIVE:To determine the characteristics of spinal lesions among each type of demyelinating diseases. METHODS:Medical records and spinal imaging of patients who were [1] older than 18years, [2] had at least one attack of TM, [3] ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Dumrikarnlert C,Siritho S,Chulapimphan P,Ngamsombat C,Satukijchai C,Prayoonwiwat N

    更新日期:2017-01-15 00:00:00

  • Altered resting state functional network connectivity in children absence epilepsy.

    abstract::Altered functional connectivity has been associated with the influence of epileptic activity. Abnormalities in connectivity, particularly in dorsal attention (DAN), salience (SN) and default mode (DMN) networks, might contribute to the loss of consciousness during seizures and cognitive deficits in patients with child...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Li Q,Cao W,Liao X,Chen Z,Yang T,Gong Q,Zhou D,Luo C,Yao D

    更新日期:2015-07-15 00:00:00

  • Crossed cerebellar diaschisis and brain tumor biochemistry studied with positron emission tomography, [18F]fluorodeoxyglucose and [11C]methionine.

    abstract::Cerebral gliomas may cause a reduction of glucose metabolism in the cerebellum contralateral to the tumor side (crossed cerebellar diaschisis, CCD). We investigated whether CCD is related to tumor localization, histological grade, size and tumor biochemistry. Cerebellar glucose metabolism was measured in 44 glioma pat...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Otte A,Roelcke U,von Ammon K,Hausmann O,Maguire RP,Missimer J,Müller-Brand J,Radü EW,Leenders KL

    更新日期:1998-01-01 00:00:00

  • Mechanisms of muscular hypertrophy.

    abstract::The effects of synergist tenotomy have been studied on rat soleus muscles after denervation and after interference with sciatic axoplasmic flow with colchicine. The results suggest that neural, as well as muscular, factors cause compensatory hypertrophy (CH) of soleus. The myogenic factor may be mild depolarization of...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hofmann WW

    更新日期:1980-03-01 00:00:00

  • Contralateral abolition of essential tremor following a pontine stroke.

    abstract::A 90-year-old man with a longstanding bilateral essential tremor presented with right-sided weakness of sudden onset. The CT scan of the brain showed a hypodense area in the left side of the pons consistent with an infarction. The paralysis disappeared without recurrence of the tremor on the right, but the tremor pers...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Nagaratnam N,Kalasabail G

    更新日期:1997-08-01 00:00:00

  • Discrete lesions in the sensorimotor control system. A clinical-topographical study of lacunar infarcts.

    abstract::In 50 patients with computed tomography-verified small, deep, lacunar, infarcts from a prospective stroke registry, we studied the lesion site in relationship with the clinical syndromes pure motor stroke, sensorimotor stroke and ataxic hemiparesis. Seventy per cent (95% confidence interval: 57-83%) of the lesions wer...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Boiten J,Lodder J

    更新日期:1991-10-01 00:00:00

  • TNF alpha, IFN gamma and IL-2 mRNA expression in CIDP sural nerve biopsies.

    abstract::Proinflammatory cytokines contribute to the regulation of the disease process in inflammatory neuropathies. Cellular localisation of cytokine expression in CIDP nerve biopsies should provide further insight into the pathogenic mechanisms of the disease and the individual cells involved. In this study in situ hybridisa...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Mathey EK,Pollard JD,Armati PJ

    更新日期:1999-02-01 00:00:00

  • Innervation of adult human laryngeal muscle fibers.

    abstract::The innervation of laryngeal muscle fibers was appraised in adult humans. Sixteen intrinsic laryngeal muscles were dissected during the autopsy of 4 adults (41-71 years old). Longitudinal serial frozen sections, 60 microm thick, of the whole muscles were double-stained for cholinesterase activity and axonal visualizat...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Périé S,St Guily JL,Callard P,Sebille A

    更新日期:1997-07-01 00:00:00

  • A fatal congenital myopathy with severe type I fibre atrophy, central nuclei and multicores.

    abstract::An unusual fatal congenital myopathy in a Chinese female infant is described. Muscle biopsy showed type I fibre smallness with central nuclei and focal decrease in oxidative enzyme activities affecting mainly larger type II fibres. Longitudinal sections from glutaldehyde-fixed araldite-embedded material stained with t...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Lee YS,Yip WC

    更新日期:1981-05-01 00:00:00