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Non-familial degenerative disease and atrophy of brainstem and cerebellum. Clinical and CT data in 47 patients.

Abstract：

:We studied the clinical features of 47 patients with a non-hereditary degenerative disease and with atrophy of brainstem or cerebellum or both in CT scanning. There was no relation between the CT findings and duration or severity of the disease, nor with the kind of the neurological signs which comprised ataxia, a hypokinetic rigid syndrome, oculomotor abnormalities, upper and lower motor neuron signs, orthostatic hypotension and dementia. The 2 main diagnoses were olivopontocerebellar atrophy (OPCA), or a combination of OPCA and striatonigral degeneration (SND). The differential diagnosis with Parkinson's disease and progressive supranuclear palsy was discussed. We concluded, that a CT scan is warranted in all cases of suspected Parkinson's disease, especially in those without tremor, and in cases of motoneuron disease with broad-based gait. In our patients with mainly hypokinesia and rigidity, levodopa treatment had no or brief beneficial effects. If ataxia predominated, OPCA appeared the most sensible diagnosis; if a hypokinetic-rigid syndrome predominated, the diagnoses SND plus OPCA appeared the most suitable. We assessed the degree of atrophy on CT subjectively, because an interobserver study of 60 normal CT scans, did not produce reliable measurements.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Staal A,Meerwaldt JD,van Dongen KJ,Mulder PG,Busch HF

doi

10.1016/0022-510x(90)90073-v

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

259-69

issue

3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(90)90073-V

journal_volume

95

pub_type

杂志文章

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