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Evaluation of the drug-induced morphological differentiation of rat glioma cells (C-6) from the aspects of S-100 protein level and con A binding pattern.

Abstract：

:The intracellular content of the nervous system specific protein S-100 began to increase with 4 days latency following the morphological differentiation of cultured rat glioma cells (C-6) with 1 mM dibutyryl cyclic AMP (dbcAMP), rising to approximately 10-fold over the control level at 15 days after the treatment. The concanavalin A (Con A) binding pattern on the external cell surface of C-6 cells exposed to dbcAMP appeared as a smooth layer of 40-60 nm thickness whereas that of control cells was irregularly thick and patchy. The correlation between morphological and biochemical changes of C-6 cells after dbcAMP treatment is discussed in relation to the mechanism controlling the differentiation of glioma cells.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Tabuchi K,Furuta T,Norikane H,Tsuboi M,Moriya Y,Nishimoto A

doi

10.1016/0022-510x(81)90065-4

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

119-30

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(81)90065-4

journal_volume

51

pub_type

杂志文章

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