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External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis.

Abstract：

:The parotid glands and part of the submandibular glands were irradiated in 18 amyotrophic lateral sclerosis patients with very advanced disease and severe drooling problems. In a prospective study, a single dosage of 7.0-7.5 Gy was administered bilateral to the larger part of the parotid glands and the posterior parts of the submandibular glands. Salivary secretion rate was assayed before and after radiotherapy. Sixteen out of eighteen patients reported satisfactory to good reduction in drooling lasting up to 4-6 months, 1/18 developed xerostomia and needed saliva substitutes, and 1/18 reported no effect. Caregivers reported positive effect in all patients. The procedure was well tolerated with few side effects. Low dosage external radiotherapy of the salivary glands is effective in reducing drooling satisfactorily in ALS patients, especially in well-hydrated patients.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Andersen PM,Grönberg H,Franzen L,Funegård U

doi

10.1016/s0022-510x(01)00631-1

subject

Has Abstract

pub_date

2001-10-15 00:00:00

pages

111-4

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022510X01006311

journal_volume

191

pub_type

临床试验,杂志文章

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