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Environmental factors and their regulation of immunity in multiple sclerosis.

Abstract：

:Epidemiological and clinical studies have shown that environmental factors such as infections, smoking and vitamin D are associated with the risk of developing multiple sclerosis (MS). Some of these factors also play a role in the MS disease course. We are currently beginning to understand how environmental factors may impact immune function in MS on a cellular and molecular level. Here we review epidemiological, clinical and basic immunological studies on the environmental factors, viral and parasitic infections, smoking, and vitamin D and relate epidemiological findings with their likely pathophysiology in MS.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Koch MW,Metz LM,Agrawal SM,Yong VW

doi

10.1016/j.jns.2012.10.021

subject

Has Abstract

pub_date

2013-01-15 00:00:00

pages

10-6

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(12)00578-3

journal_volume

324

pub_type

杂志文章,评审

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