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Involvement of hippocampus in Creutzfeldt-Jakob disease.

Abstract：

:The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Mizusawa H,Hirano A,Llena JF

doi

10.1016/0022-510x(87)90003-7

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

13-26

issue

1-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(87)90003-7

journal_volume

82

pub_type

杂志文章

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