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Elevated fasting blood glucose is predictive of the severity and poor outcome in nondiabetic patients with cerebral venous thrombosis.

Abstract：

BACKGROUND AND PURPOSE:Although elevated fasting blood glucose (FBG) at admission is associated with poor outcome in patients with ischemic and hemorrhagic stroke, it has not been investigated in patients with cerebral venous thrombosis (CVT). We aimed to determine the correlation between elevated FBG and severity and outcome among CVT patients. METHODS:Consecutive CVT patients between 2009 and 2019 were identified for this retrospective study. Patients with a history of diabetes mellitus or incomplete clinical data were excluded. Hyperglycemia was defined as FBG ≥ 6.1 mmol/L, further classified as mild (6.1-6.9 mmol/L) and severe hyperglycemia (≥7.0 mmol/L). The severity of CVT was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), CVT-related complications, and intracranial pressure. The outcome was assessed at discharge using mRS; mRS 3-6 indicated poor outcome. RESULTS:Of 160 patients, 36 (22.5%) had hyperglycemia, and 24 (15%) had severe hyperglycemia. Baseline FBG positively correlated with NIHSS at admission (r = 0.55, P < .001). Patients with hyperglycemia had higher baseline mRS scores (P < .001), higher incidence of cerebral venous infarction (P = .039), intracranial hemorrhage (P = .005), coma (P < .001), and seizure (P = .010). Multivariate regression analysis revealed that patients with hyperglycemia had a higher risk of poor outcome (adjusted OR: 4.47; 95% CI: 1.05-18.95), and subgroup analysis showed that severe hyperglycemia (adjusted OR: 6.66; 95% CI: 1.35-32.81) was a stronger independent predictor of poor outcome. CONCLUSIONS:Admission FBG was associated with severity of CVT, and elevated FBG is a predictor of short-term poor outcome among CVT patients.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Wu Y,Zhou L,Yao M,Zhu Y,Ni J,Cui L,Peng B

doi

10.1016/j.jns.2020.117017

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

117017

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(20)30354-3

journal_volume

417

pub_type

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Elevated fasting blood glucose is predictive of the severity and poor outcome in nondiabetic patients with cerebral venous thrombosis.