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Chronic progressive spinobulbar spasticity with disturbance of voluntary eyelid closure. Report of a case with special reference to MRI and electrophysiological findings.

Abstract：

:We describe a 56-year-old man who had a progressive pseudobulbar palsy, spastic tetraparesis, forced laughing and disturbance of voluntary eyelid closure, and was clinically compatible with chronic progressive spinobulbar spasticity. Magnetic resonance images (MRI) revealed atrophy of the bilateral motor cortices and single photon emission tomography after intravenous injection of N-isopropyl-p-iodoamphetamine iodine-123 (IMP-SPECT) showed hyporadioactivity in the same regions. Electrophysiological studies on supranuclear paralysis of eyelid closure demonstrated that so-called apraxia and motor impersistence coexisted and that in attempts to keep the eyelid closed the inhibition of basal activity of the levator palpebrae superioris muscle and activation of the orbicularis oculi muscle were insufficient, indicating the impaired reciprocity of these ocular muscles. The corresponding lesion of these eyelid symptoms was considered to be the bilateral motor cortices.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Nishimura M,Tojima M,Suga M,Hirose K,Tanabe H

doi

10.1016/0022-510x(90)90131-6

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

183-90

issue

2-3

eissn

0022-510X

issn

1878-5883

pii

0022-510X(90)90131-6

journal_volume

96

pub_type

杂志文章

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