Multiple paraneoplastic syndromes: myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma.

abstract：:Recent studies have demonstrated that cytokines play an important role in the pathogenesis of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important proinflammatory cytokine. In our study, we investigated the association of genetic variants within the gene encoding interleukin-6-572G/C (IL-6-572G/C) with I...

journal_title：Journal of the neurological sciences

authors： Zhang G,Tu Y,Feng W,Huang L,Li M,Qi S

更新日期：2011-07-15 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1 (CMT1) is a common disorder of the peripheral nervous system. The underlying genetic cause is highly heterogeneous, and mutations in SIMPLE (small integral membrane protein of lysosome/late endosome) represent a rare cause of CMT type 1, named CMT1C. Herein, we report the clinical, e...

journal_title：Journal of the neurological sciences

authors： Ciotti P,Luigetti M,Geroldi A,Capponi S,Pezzini I,Gulli R,Pazzaglia C,Padua L,Massa R,Mandich P,Bellone E

更新日期：2014-08-15 00:00:00

abstract：:Common pathogenic mechanisms may be involved in the prevalence of ischemic stroke and coronary heart disease. Recently, genome-wide association (GWA) studies identified a chromosome region (9p21) that confers the risk of coronary heart disease. In a hospital-based case-control study conducted in Chinese Hans, we teste...

journal_title：Journal of the neurological sciences

authors： Li SJ,Hu WL,Liu DT,Sun FH,Zhang Q,Yang XC,Yu SZ,Jin L,Wang XF

更新日期：2009-09-15 00:00:00

abstract：:We evaluated the efficacy of low-dose, add-on therapy of CLB in adults with refractory epilepsy. 28 patients were included: 12 with temporal lobe epilepsy (TLE), 14 with extratemporal lobe epilepsy (ETLE) and 2 with symptomatic generalized epilepsy (SGE). CLB was added with the initial dose of 2.5 mg/day and increased...

journal_title：Journal of the neurological sciences

authors： Kinoshita M,Ikeda A,Begum T,Terada K,Shibasaki H

更新日期：2007-12-15 00:00:00

abstract：:Ultrastructural alterations were observed in the sciatic nerve of dystrophic mice. Myelin sheaths were abnormal in shape, abruptly ceased beyond a node of Ranvier, leaving the axon naked. These changes were seen in both afferent and efferent nerve fibres. Apparent embryonal Schwann cells and Schwann cells which were a...

journal_title：Journal of the neurological sciences

authors： Okada E,Mizuhira V,Nakamura H

更新日期：1976-08-01 00:00:00

abstract：:The clinical, genetic and electrophysiological study of 3 patients with an association of a neuronal form of Charcot-Marie-Tooth Disease (CMTD) with a syndrome of continuous motor unit activity (CMUA) are reported, with light and electron microscopy of muscle and sural nerve biopsies in 2 patients. The unusual clinica...

journal_title：Journal of the neurological sciences

authors： Vasilescu C,Alexianu M,Dan A

更新日期：1984-01-01 00:00:00

abstract：:A single blind randomized study has been conducted in 216 patients with severe or moderate head injury, with the aim of comparing the evolution of those that received only conventional treatment with the evolution of those treated with CDP-choline. Our results indicate that CDP-choline improves the global outcome of p...

journal_title：Journal of the neurological sciences

authors： Calatayud Maldonado V,Calatayud Pérez JB,Aso Escario J

更新日期：1991-07-01 00:00:00

abstract：:We investigated superoxide dismutase (SOD) activity in human cerebrospinal fluid (CSF) as an index of the aging process in the central nervous system (CNS). The subjects were 61 individuals aged 21-77 years, comprising 24 men and 37 women without organic disorders of the nervous system. SOD activity in CSF was measure...

journal_title：Journal of the neurological sciences

authors： Okabe T,Hamaguchi K,Inafuku T,Hara M

更新日期：1996-09-15 00:00:00

abstract：:Prefrontal corticofugal systems, as studied with anterograde HRP histochemistry, revealed projections to preoculomotor and oculomotor centers in the diencephalon and brainstem which may underlie direct cortical influence on eye movement. Because of the location of these preoculomotor trajectories, stimulation and lesi...

journal_title：Journal of the neurological sciences

authors： Leichnetz GR

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. OBJECTIVES:The aim...

journal_title：Journal of the neurological sciences

authors： Uher T,Benedict RH,Horakova D,Bergsland N,Dusankova JB,Tyblova M,Ramasamy DP,Seidl Z,Vaneckova M,Krasensky J,Havrdova E,Zivadinov R

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:In clinical trials drop out bias reduces the validity of results. This is a particular problem in long-term multiple sclerosis (MS) studies, particularly when patients become progressively disabled and have increasing difficulty attending assessment clinics. OBJECTIVE:To assess the validity of nurse led tel...

journal_title：Journal of the neurological sciences

authors： Huda S,Cavey A,Izat A,Mattison P,Boggild M,Palace J

更新日期：2016-03-15 00:00:00

abstract：:Vitamin B1- and B-deficient encephalopathy was produced in adult Wistar rats and the effect of methylcobalamin was studied. These experiments were performed in vitamin B1- or B-deficient rats with or without the administration of guanidine, a magnesium antagonist. These encephalopathic rats showed symmetrical lesions ...

journal_title：Journal of the neurological sciences

authors： Goto I,Nagara H,Tateishi J,Kuroiwa Y

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Reports regarding outcome of Guillain-Barré syndrome (GBS) are usually limited to relatively short follow-up. We assessed the occurrence of fatigue and correlated it to clinical measures in patients who had suffered from GBS over 20 years previously. METHODS:We contacted 24 patients with GBS requiring in-...

journal_title：Journal of the neurological sciences

authors： Drory VE,Bronipolsky T,Bluvshtein V,Catz A,Korczyn AD

更新日期：2012-05-15 00:00:00

abstract：:The pattern of arterial occlusion and related lesions have been studied in 26 cases with 38 medullary infarcts. In 10 of these cases, only the intracranial vessels were examined. In the 16 other cases, the entire cerebral arterial supply was dissected. Medial infarcts were more often related to occlusion of the verteb...

journal_title：Journal of the neurological sciences

authors： Escourolle R,Hauw JJ,Agopian PD,Trelles L

更新日期：1976-05-01 00:00:00

abstract：:An expanded hexanucleotide repeat in the chromosome 9 open reading frame 72 (C9ORF72), on chromosome 9p21, has recently been identified as a major cause of familial frontotemporal dementia (FTD). The neuropathology and clinical characteristics associated with C9ORF72 mutations are heterogeneous with the unknown pathom...

journal_title：Journal of the neurological sciences

authors： Liu Y,Yu JT,Sun FR,Ou JR,Qu SB,Tan L

更新日期：2013-12-15 00:00:00

abstract：:Cultured post-fused human skeletal muscle monolayers exposed to WSN influenza A virus were analyzed by scanning and transmission electron microscopy. At 12-14h post-inoculation (p.i.), affected mononuclear cells retracted from the cell surface, but remained anchored to the substrate by taut filar processes. Retraction...

journal_title：Journal of the neurological sciences

authors： Miranda AF,Gamboa ET,Armstrong CL,Hsu KC

更新日期：1978-03-01 00:00:00

abstract：:The muscarinic acetylcholine receptors were identified in membrane preparations from human tissues by the specific binding of 1-[benzilic-4,4'-3H] quinuclidinyl benzilate. Saturation binding isotherms of this radioligand yielded a total amount of receptors of 435 +/- 208, 159 +/- 65 and 913 +/- 89 fmol/mg protein, res...

journal_title：Journal of the neurological sciences

authors： Vanderheyden P,Gies JP,Ebinger G,De Keyser J,Landry Y,Vauquelin G

更新日期：1990-06-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) occurs more commonly in men than in women, and women get the disease later in life compared to men. This epidemiologic aspect of the disease raises the question as to whether estrogen may be neuroprotective in delaying or preventing ALS. Postmenopausal women with ALS were separated ...

journal_title：Journal of the neurological sciences

authors： Rudnicki SA

更新日期：1999-10-31 00:00:00

abstract：OBJECTIVES:To compare the clinical course and muscle biopsy features of polymyositis with mitochondrial pathology (PM-Mito) to inclusion body myositis (IBM) and steroid-responsive inflammatory myopathies (polymyositis). METHODS:We compared clinical, laboratory and myopathologic features in a retrospective study of pat...

journal_title：Journal of the neurological sciences

authors： Temiz P,Weihl CC,Pestronk A

更新日期：2009-03-15 00:00:00

abstract：:Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward s...

journal_title：Journal of the neurological sciences

authors： Santangelo G,Piscopo F,Barone P,Vitale C

更新日期：2017-03-15 00:00:00

abstract：:There is evidence that visuo-spatial capacity can become overloaded when processing a secondary visual task (Dual Task, DT), as occurs in daily life. Hence, we investigated the influence of the visuo-spatial interference in the identification of emotional facial expressions (EFEs) in early stages of Parkinson's diseas...

journal_title：Journal of the neurological sciences

authors： García-Rodríguez B,Guillén CC,Barba RJ,io Valladolid GR,Arjona JA,Ellgring H

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is offered to amyotrophic lateral sclerosis (ALS) patients with severe dysphagia. Immediate benefits of PEG are adequate food intake and weight stabilization. However, the impact of PEG on survival is still uncertain. In this work we retrospectively evaluated the eff...

journal_title：Journal of the neurological sciences

authors： Spataro R,Ficano L,Piccoli F,La Bella V

更新日期：2011-05-15 00:00:00

abstract：:In addition to neuritic changes and amyloid deposits, neuronal and glial cell apoptosis is an important pathological feature of Alzheimer's disease (AD). Several factors have been postulated as causes or triggers of cellular apoptotic change. This study focused on a quantifiable relationship between phosphorylation si...

journal_title：Journal of the neurological sciences

authors： Kobayashi K,Nakano H,Hayashi M,Shimazaki M,Fukutani Y,Sasaki K,Sugimori K,Koshino Y

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:The effects of smoking on clinical outcomes following acute stroke remain controversial. METHODS:We evaluated the influence of smoking on 90-day outcomes after acute atherothrombotic stroke in 292 Japanese men extracted from the database of the Edaravone and Argatroban Stroke Therapy for Acute Ischemic Stro...

journal_title：Journal of the neurological sciences

authors： Kumagai N,Okuhara Y,Iiyama T,Fujimoto Y,Takekawa H,Origasa H,Kawanishi Y,Yamaguchi T

更新日期：2013-12-15 00:00:00

abstract：:Functional and structural damage in postanoxic persistent vegetative state (PVS) was analysed using 18fluorodeoxyglucose PET (FDG-PET) coregistered to 3-D MRI in combination with morphometric 3-D MRI analysis (voxel-based morphometry, VBM). In five patients in late stages of non-traumatic PVS, combined analysis using ...

journal_title：Journal of the neurological sciences

authors： Juengling FD,Kassubek J,Huppertz HJ,Krause T,Els T

更新日期：2005-02-15 00:00:00

abstract：:The pathogenesis of MS has become better understood as a result of recent advances in several areas, particularly in epidemiology and neuro-imaging. A number of epidemiologically based conclusions need to be revised, most importantly the putative direct relationship between prevalence and latitude, and the concept tha...

journal_title：Journal of the neurological sciences

authors： Poser CM

更新日期：1992-02-01 00:00:00

abstract：:A 52-year-old Caucasian male with typical features of myotonic dystrophy (MD) developed a lung abscess and was found to have a mild atypical cyclic neutropenia. Granulocyte function testing revealed a defect in phagocytosis, bactericidal activity and chemotaxis. The defects were less severe at the nadir of the granulo...

journal_title：Journal of the neurological sciences

authors： Friedenberg WR,Marx JJ Jr,Hansotia P,Gottschalk PG

更新日期：1986-03-01 00:00:00

abstract：:Frontal gaits (FG) and parkinsonian gaits (PG) are common neurological gait abnormalities in older adults. It may be difficult to distinguish these gaits as they share common clinical characteristics such as unsteadiness, slowing, and shuffling. Of 488 community-residing subjects in an aging study, 11 were diagnosed w...

journal_title：Journal of the neurological sciences

authors： Ambrose A,Levalley A,Verghese J

更新日期：2006-10-25 00:00:00

abstract：:We cloned a previously characterized glioblastoma-derived parent cell line (12-18) in order to obtain a relatively homogenous population of human neural cells of neoplastic origin. These cells reach high densities in culture (over 100,000 cells/cm2) and have a high mean DNA content per cell of 18.1 +/- 0.9 pg. A histo...

journal_title：Journal of the neurological sciences

authors： Liepkalns VA,Icard-Liepkalns C,Sommer AM,Quigley JP

更新日期：1982-12-01 00:00:00

abstract：:In a prospective study, we analysed the presence of monoclonal immunoglobulin (moIg) in the serum from 30 patients with amyotrophic lateral sclerosis (ALS) and 30 matched controls using a sensitive Western blot technique. The incidence of serum moIg was 60% in the ALS group and 13.3% in the control group. Most ALS ser...

journal_title：Journal of the neurological sciences

authors： Duarte F,Binet S,Lacomblez L,Bouche P,Preud'homme JL,Meininger V

更新日期：1991-07-01 00:00:00