The prefrontal cortico-oculomotor trajectories in the monkey.

abstract：:Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal (+/+) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed. In contrast, the myelin cholesterol: phospholipid:...

journal_title：Journal of the neurological sciences

authors： Sena A,Sarliève LL,Rebel G

更新日期：1985-05-01 00:00:00

abstract：:A method is described which characterises the conduction deficit of a nerve in terms of the distribution of the refractory periods of transmission (RPTs) of its constituent fibres. The RPT is a particularly sensitive index of conduction deficit and measures the ability of a nerve fibre to conduct pairs of closely spac...

journal_title：Journal of the neurological sciences

authors： Smith KJ

更新日期：1980-11-01 00:00:00

abstract：:Acute cortical lesions rarely cause vertigo. We report a 51-year-old patient presenting with an acute vestibular syndrome including spontaneous vertigo and nystagmus, lateropulsion and nausea due to middle cerebral artery infarction. The central origin of the acute vestibular syndrome was revealed by a normal head imp...

journal_title：Journal of the neurological sciences

authors： von Brevern M,Süßmilch S,Zeise D

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:There is a need for biomarkers that can classify optic neuritis (ON) attacks as belonging to either neuromyelitis optica spectrum disorder with optic neuritis (NMOSD-ON) or relapsing remitting multiple sclerosis with optic neuritis (MS-ON). This study uses spectral domain optical coherence tomography (SD-OCT...

journal_title：Journal of the neurological sciences

authors： Bertsch-Gout M,Loeb R,Finch AK,Javed A,Bernard J

更新日期：2018-01-15 00:00:00

abstract：:The Alzheimer's disease (AD) related amyloid precursor protein (APP) is stored, cleaved and released similarly from neurons and from platelets. We have reported that the proportion of 120-130 to 110 kDa carboxyl-cleaved APP present in the platelets of AD patients is significantly lower than that of platelets of age-ma...

journal_title：Journal of the neurological sciences

authors： Baskin F,Rosenberg RN,Iyer L,Schellenberg GD,Hynan L,Nee LE

更新日期：2001-01-15 00:00:00

abstract：:In 1977 and 1978 Cook and his associates demonstrated a positive association between ownership of small dogs and both familial and sporadic cases of multiple sclerosis in New Jersey. Because of the far reaching implications of this work, a similar study was carried out and 72 patients with clinically definite multiple...

journal_title：Journal of the neurological sciences

authors： Read D,Nassim D,Smith P,Patterson C,Warlow C

更新日期：1982-09-01 00:00:00

abstract：:Recently, TAR DNA-binding protein of 43-kDa (TDP-43) was identified as a major component of ubiquitinated neuronal cytoplasmic inclusions observed in lower motor neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions. We herein investigated the relationship b...

journal_title：Journal of the neurological sciences

authors： Fujita Y,Mizuno Y,Takatama M,Okamoto K

更新日期：2008-06-15 00:00:00

abstract：:To elucidate the T helper 1 (Th1)/T helper 2 (Th2) balance in various inflammatory neuropathies, we measured the ratio of intracellular interferon-gamma (IFN-gamma)-positive to IL-4-positive cells (intracellular IFN-gamma/IL-4 ratio) by flow cytometry in peripheral blood CD4(+) T cells of 14 patients with mononeuritis...

journal_title：Journal of the neurological sciences

authors： Horiuchi I,Ochi H,Murai H,Osoegawa M,Minohara M,Furuya H,Kira J

更新日期：2001-12-15 00:00:00

abstract：BACKGROUND:A recent pilot study suggested spasticity improvement during glatiramer acetate (GA) treatment in multiple sclerosis (MS) patients who previously received interferon-β (IFN-β). OBJECTIVE:To evaluate changes in spasticity in MS patients switching from IFN-β to GA. METHODS:Observational, multicentre study in...

journal_title：Journal of the neurological sciences

authors： Meca-Lallana JE,Balseiro JJ,Lacruz F,Guijarro C,Sanchez O,Cano A,Costa-Frossard L,Hernández-Clares R,Sanchez-de la Rosa R,Escala Study Group.

更新日期：2012-04-15 00:00:00

abstract：:Cerebral gliomas may cause a reduction of glucose metabolism in the cerebellum contralateral to the tumor side (crossed cerebellar diaschisis, CCD). We investigated whether CCD is related to tumor localization, histological grade, size and tumor biochemistry. Cerebellar glucose metabolism was measured in 44 glioma pat...

journal_title：Journal of the neurological sciences

authors： Otte A,Roelcke U,von Ammon K,Hausmann O,Maguire RP,Missimer J,Müller-Brand J,Radü EW,Leenders KL

更新日期：1998-01-01 00:00:00

abstract：:We report a 2-year-old girl who presented with delayed development, weakness and persistent vomiting. She had a demyelinating peripheral neuropathy. The activity of cytochrome oxidase in skeletal muscle from the patient was 10% of controls. Immunochemical studies using antibodies to holo-cytochrome oxidase and the ind...

journal_title：Journal of the neurological sciences

authors： Shepherd IM,Birch-Machin MA,Johnson MA,Sherratt HS,Aynsley-Green A,Droste M,Kadenbach B,Stephenson JB,King MD,Dick DJ

更新日期：1988-11-01 00:00:00

abstract：:In this study, we evaluated magnetization transfer ratio values in the brain white matter of siblings of multiple sclerosis (MS) patients and compared them to those obtained in sex- and age-matched normal controls. No statistically significant difference was found between the two groups for all the white matter areas ...

journal_title：Journal of the neurological sciences

authors： Filippi M,Campi A,Martino G,Colombo B,Comi G

更新日期：1997-04-15 00:00:00

abstract：:The physiological and histological changes following injection of 10 microliter of proteinase K into the rat tibial nerve have been compared with those induced by proteinase K and specific inhibitor phenylmethylsulphonyl fluoride (PMSF) and also by rabbit experimental allergic neuritis (EAN) serum. Proteinase K and PM...

journal_title：Journal of the neurological sciences

authors： Westland K,Pollard JD

更新日期：1987-12-01 00:00:00

abstract：:Motor evoked potentials (MEP) were recorded in 23 patients with definite relapsing multiple sclerosis before and after treatment with a short course of high dose of methylprednisolone. MEP were performed together with clinical examination just before treatment, and 6 and 60 days later. The following results were obser...

journal_title：Journal of the neurological sciences

authors： Salle JY,Hugon J,Tabaraud F,Boulesteix JM,Vallat JM,Dumas M,Poser CM

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To determine the influence of different factors on test-retest reliability of frequently used transcranial magnetic stimulation (TMS) parameters while controlling for potential confounders in healthy subjects. METHODS:TMS was applied in 93 healthy volunteers (61% male) twice (mean retest interval of 34.0 ± 2...

journal_title：Journal of the neurological sciences

authors： Hermsen AM,Haag A,Duddek C,Balkenhol K,Bugiel H,Bauer S,Mylius V,Menzler K,Rosenow F

更新日期：2016-03-15 00:00:00

abstract：:Complement-dependent gliotoxic antibody activity was determined in 22 patients with multiple sclerosis (MS) and 19 normal control persons. Peripheral blood serum was collected from MS patients at about 4-week intervals for one year, and the results of cytotoxicity tests correlated with the course of disease. For 10 MS...

journal_title：Journal of the neurological sciences

authors： Mar P,Gradl T,Dörner C

更新日期：1979-05-01 00:00:00

abstract：:The clinical features, results of nerve conduction studies and sural nerve biopsy findings have been compared in 5 patients with chronic relapsing polyneuropathy in whom plasma exchange was used in treatment. In 2 patients who consistently responded to plasma exchange, the dominant pathological findings was segmental ...

journal_title：Journal of the neurological sciences

authors： Pollard JD,McLeod JG,Gatenby P,Kronenberg H

更新日期：1983-02-01 00:00:00

abstract：:We show here that the major glycolipid in myelin, galactocerebroside, is not only a useful marker for isolated bovine oligodendrocytes but that its quantitation can serve as a probe for cell differentiation. We have produced in the rabbit antisera to bovine oligodendroglia, bovine myelin and galactocerebroside. The bi...

journal_title：Journal of the neurological sciences

authors： Steck AJ,Perruisseau G

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:To describe additional cases of subacute encephalopathy with seizures in alcoholics (SESA) syndrome, and to question the clinical and radiological course. METHODS:We retrospectively analyzed the clinical characteristics, electroencephalography (EEG), MRI studies at the admission and over the following 6 months...

journal_title：Journal of the neurological sciences

authors： Duwicquet C,Biberon J,Corcia P,De Toffol B,Limousin N

更新日期：2019-01-15 00:00:00

abstract：:Experimental allergic neuritis has been induced in 52 guinea pigs by the inoculation of rabbit peripheral nerve in Freund's adjuvant. The majority of the animals developed an acute monophasic illness after a mean interval of 16 days and, if they survived, recovered fully after an average period of 52 days. Two animal...

journal_title：Journal of the neurological sciences

authors： Pollard JD,King RH,Thomas PK

更新日期：1975-03-01 00:00:00

abstract：:We report two patients displaying hyperintensities on diffusion-weighted imaging (DWI) in the area of Wallerian degeneration (WD) at 12 days after stroke. High signal intensities were more conspicuous on DWI than on T2-weighted images. Both patients showed decreased diffusion anisotropy resulting in elevated apparent ...

journal_title：Journal of the neurological sciences

authors： Kang DW,Chu K,Yoon BW,Song IC,Chang KH,Roh JK

更新日期：2000-09-15 00:00:00

abstract：:Based on the development of a transgenic animal model, an increasing number of experimental strategies have revealed the potential to modify the selective degeneration of motor neurons, a feature unique to motor neuron diseases such as amyotrophic lateral sclerosis (ALS). The translation of this success into therapeut...

journal_title：Journal of the neurological sciences

authors： Karitzky J,Ludolph AC

更新日期：2001-10-15 00:00:00

abstract：:Our objective was to apply the technique of measuring diameters of optic nerve sheath (ONSD) for the intracranial pressure assessment for the cases with traumatic head injury without hemorrhage. In a retrospective study, CT data of 720 adult patients were collected and analyzed. ONSDs were measured at the point where ...

journal_title：Journal of the neurological sciences

authors： Bekerman I,Sigal T,Kimiagar I,Vaiman M

更新日期：2016-09-15 00:00:00

abstract：:In five patients with cerebral manifestation of Wilson's disease, copper was measured in CSF, serum, urine and liver, and ceruloplasmin was determined in CSF and serum. CSF copper was found to be elevated in all cases, especially in the four examined before therapy. Two patients were followed up for a period of 3 year...

journal_title：Journal of the neurological sciences

authors： Weisner B,Hartard C,Dieu C

更新日期：1987-06-01 00:00:00

abstract：:The study's objectives were to assess the predictive significance of different sets of demographic, clinical and extraclinical variables in identifying multiple sclerosis patients with various risk levels of worsening during the follow-up, in order to provide clues to inclusion criteria and selection of primary clinic...

journal_title：Journal of the neurological sciences

authors： Amato MP,Ponziani G,Bartolozzi ML,Siracusa G

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:Progressive multifocal leukoencephalopathy, caused by oligodendrocyte lytic infection by JCVirus, is a growing concern for patients undergoing immune modulatory therapies for treatment of autoimmune diseases, such as multiple sclerosis (MS). The objective of JEMS was to describe the prevalence of anti-JCV an...

journal_title：Journal of the neurological sciences

authors： da Silva AM,Santos ME,Portuguese JEMS Study Investigators.

更新日期：2014-02-15 00:00:00

abstract：:We have investigated protein expression and genotype in 59 Becker muscular dystrophy (BMD) patients. The aim was to identify possible causes of the marked variability in phenotype in patients with similar deletions/mutations. The patients were examined neurologically and functionally and underwent Manual Muscle Testin...

journal_title：Journal of the neurological sciences

authors： Morandi L,Mora M,Confalonieri V,Barresi R,Di Blasi C,Brugnoni R,Bernasconi P,Mantegazza R,Dworzak F,Antozzi C

更新日期：1995-10-01 00:00:00

abstract：:We assessed the incidence of hemorrhagic transformation and infarct volume after early intravenous infusion of recombinant human tissue plasminogen activator (rht-PA) in a newly developed rat cerebral embolic model. Male Wistar rats (n=60) were subjected to middle cerebral artery (MCA) occlusion by a single fibrin ric...

journal_title：Journal of the neurological sciences

authors： Zhang RL,Chopp M,Zhang ZG,Divine G

更新日期：1998-09-18 00:00:00

abstract：BACKGROUND:Microglial activation is thought to be a key pathophysiological mechanism underlying disease activity in all forms of MS. Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory properties that is widely used in the treatment of rheumatological diseases. In this series of experiments, we explo...

journal_title：Journal of the neurological sciences

authors： Koch MW,Zabad R,Giuliani F,Hader W Jr,Lewkonia R,Metz L,Wee Yong V

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:In the diagnostic work-up of young stroke patients angiography is still considered as mandatory to identify otherwise undetected causes of stroke. We hypothesized that stroke cause is more heterogeneous among patients with a territorial infarct, whereas in lacunar stroke it is generally small vessel disease....

journal_title：Journal of the neurological sciences

authors： de Jong S,Lodder J,Luijckx GJ

更新日期：2004-07-15 00:00:00