当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.

CSF copper concentration: a new parameter for diagnosis and monitoring therapy of Wilson's disease with cerebral manifestation.

Abstract：

:In five patients with cerebral manifestation of Wilson's disease, copper was measured in CSF, serum, urine and liver, and ceruloplasmin was determined in CSF and serum. CSF copper was found to be elevated in all cases, especially in the four examined before therapy. Two patients were followed up for a period of 3 years, while undergoing therapy with chelating substances. In case 1, the data and the clinical course are presented in detail: prior to therapy, the daily urinary copper excretion had been elevated, and this increased during the initial treatment stages. The serum copper concentration, which was already low, decreased quickly the during the initial stages of therapy, and remained at a low level during further treatment. In contrast to its level in serum, the copper level in the CSF was up to 3-fold the normal range and fell only very slowly as clinical symptoms improved. These findings suggest transport of copper from the CNS to the CSF. The copper concentration in CSF appears to be a valuable parameter for diagnosis and monitoring therapy in patients with cerebral manifestation of Wilson's disease.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Weisner B,Hartard C,Dieu C

doi

10.1016/0022-510x(87)90275-9

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

229-37

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

0022-510X(87)90275-9

journal_volume

79

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Anterior horn cell loss from subdural hygroma: a consequence of spontaneous spinal fluid leak.

    abstract：:We describe a case of a 50-year-old man with bilateral shoulder girdle weakness caused by anterior subdural hygroma secondary to a previous spontaneous CSF leak. The CSF leak occurred and resolved 16 years prior to presenting with a 6-year progressive painless, asymmetric proximal muscle weakness involving both upper ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.02.029

    authors： Mihaylova T,Biondo A,Zak I,Lewis RA

    更新日期：2011-06-15 00:00:00

  • The contribution of wall shear stress insult to the growth of small unruptured cerebral aneurysms in longitudinal 3D-TOF-MRA.

    abstract：OBJECTIVE:Aneurysm growth is a risk factor for rupture, however the detailed mechanism remains unclear. The present study was performed to identify whether hemodynamic insult could prompt small unruptured aneurysms to grow. METHODS:Six pairs of unruptured small (<5 mm) cerebral aneurysms from patients followed with lo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116798

    authors： Sun L,Wang J,Li M,Li M,Zhu Y

    更新日期：2020-06-15 00:00:00

  • The presence of autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptor in the blood serum of patients with epilepsy.

    abstract：:We have analyzed the serum from patients with refractory epilepsy for the presence of autoreactive antibodies to AMPA glutamate receptor subunits. The presence and the level of autoantibodies were assessed using immunoblot and ELISA with synthetic peptides specific for subregions of AMPA glutamate receptor subunits. P...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00150-0

    authors： Dambinova SA,Izykenova GA,Burov SV,Grigorenko EV,Gromov SA

    更新日期：1997-11-06 00:00:00

  • Spinal cord blood flow measured by a hydrogen clearance technique.

    abstract：:Spinal cord blood flow (SCBF) has been measured in segments of the thoracolumbar cord of dogs using the hydrogen clearance technique. Clearances were recorded and flows calculated from electrodes placed in grey and white matter. The position of the recording electrodes was marked by diathermy and confirmed in each exp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(75)90054-4

    authors： Griffiths IR,Rowan JO,Crawford RA

    更新日期：1975-12-01 00:00:00

  • Changes in superficial temporal artery blood flow and cerebral hemodynamics after extracranial-intracranial bypass surgery in moyamoya disease and atherothrombotic carotid occlusion.

    abstract：:This study included 40 consecutive patients with athrothrombotic carotid occlusive disease (A-group) and 13 consecutive patients with moyamoya disease (M-group) who had an internal carotid artery occlusion and underwent EC-IC bypass. Flow velocity and diameter of the operated STA on duplex ultrasonography (STDU), as w...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.11.006

    authors： Fujimoto S,Toyoda K,Inoue T,Jinnouchi J,Kitazono T,Okada Y

    更新日期：2013-02-15 00:00:00

  • Association of interleukin-6-572G/C gene polymorphisms in the Cantonese population with intracranial aneurysms.

    abstract：:Recent studies have demonstrated that cytokines play an important role in the pathogenesis of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important proinflammatory cytokine. In our study, we investigated the association of genetic variants within the gene encoding interleukin-6-572G/C (IL-6-572G/C) with I...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.03.036

    authors： Zhang G,Tu Y,Feng W,Huang L,Li M,Qi S

    更新日期：2011-07-15 00:00:00

  • Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody.

    abstract：:Anti-Yo antibodies are present in the sera and cerebrospinal fluid of some patients with paraneoplastic cerebellar degeneration (PCD), but there is no evidence that the presence of anti-Yo antibodies causes the Purkinje cell loss seen in PCD patients. We examined the level of cytotoxic T lymphocyte (CTL) activity agai...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00163-x

    authors： Tanaka M,Tanaka K,Tokiguchi S,Shinozawa K,Tsuji S

    更新日期：1999-09-15 00:00:00

  • Effect of mild cognitive impairment on balance.

    abstract：OBJECTIVE:To investigate the effect of mild cognitive impairment (MCI) on balance. METHODS:87 subjects with subjective memory impairment were enrolled, and subdivided into two groups, MCI and non-MCI, according to diagnostic criteria of amnestic subtype of MCI according to the 1999 MCI international panel (Current Con...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.02.031

    authors： Shin BM,Han SJ,Jung JH,Kim JE,Fregni F

    更新日期：2011-06-15 00:00:00

  • Delayed neurite regeneration and its improvement by nerve growth factor (NGF) in dorsal root ganglia from MRL-lpr/lpr mice in vitro.

    abstract：:We studied neurite regeneration in MRL-lpr/lpr mice, a murine model of systemic lupus erythematosus, using a culture system to investigate the influences of immunological abnormalities on neurons. The regeneration of cultured dorsal root ganglion (DRG) neurons from MRL-lpr/lpr mice was delayed compared with control MR...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)05216-1

    authors： Hikawa N,Kiuchi Y,Maruyama T,Takenaka T

    更新日期：1997-07-01 00:00:00

  • Very early activation of m-calpain in peripheral nerve during Wallerian degeneration.

    abstract：:Peripheral nerve injury results in a series of events culminating in degradation of the axonal cytoskeleton (Wallerian degeneration). In the time period between axotomy and cytoskeletal degradation (24-48 h in rodents), there is calcium entry and activation of calpains within the axon. The precise timing of these even...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00013-8

    authors： Glass JD,Culver DG,Levey AI,Nash NR

    更新日期：2002-04-15 00:00:00

  • Glycogen accumulated in the brain following insults is not degraded during a subsequent period of ischemia.

    abstract：:The primary objective of this study was to attempt to induce excessive intraglial acidosis during ischemia by subjecting rats to an initial insult which leads to post insult accumulation of glycogen, presumed to accumulate primarily in astrocytes. The initial insults were 15 min of transient forebrain ischemia, 30 min...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(96)82226-x

    authors： Folbergrova J,Katsura KI,Siesjo BK

    更新日期：1996-04-01 00:00:00

  • Monocyte phenotype in blood and cerebrospinal fluid: compartment-specific pattern is unrelated to neurological disease.

    abstract：:An immunocytochemical study of surface and cytoplasmic markers of the monocyte/macrophage lineage was undertaken on peripheral blood (PB) and cerebrospinal fluid (CSF) cells in patients with multiple sclerosis (MS) or other neurological diseases (OND) and in three healthy controls. Size and granularity were assessed b...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90274-3

    authors： Salmaggi A,Sandberg-Wollheim M

    更新日期：1993-12-15 00:00:00

  • Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing beta-interferon therapy.

    abstract：OBJECTIVE:Multiple sclerosis (MS) is a disabling idiopathic inflammatory disorder with evidence of immune dysfunction. Current therapies for MS include preparations of beta-interferon (beta IFN). We studied the gene expression patterns in peripheral blood mononuclear cells from relapsing-remitting MS patients undergoin...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.02.034

    authors： Singh MK,Scott TF,LaFramboise WA,Hu FZ,Post JC,Ehrlich GD

    更新日期：2007-07-15 00:00:00

  • Treatment and outcome of myasthenia gravis: retrospective multi-center analysis of 470 Japanese patients, 1999-2000.

    abstract：:To clarify the current status of treatments and outcomes of patients with myasthenia gravis (MG) in Japan, a total of 470 patients (164 men and 306 women; mean age 41 years) were recruited from 19 Japanese tertiary medical centers in 1999-2000. Thymectomy was performed in 319 (68%) of the patients. Patients who receiv...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2003.09.016

    authors： Kawaguchi N,Kuwabara S,Nemoto Y,Fukutake T,Satomura Y,Arimura K,Osame M,Hattori T,Study Group for Myasthenia Gravis in Japan.

    更新日期：2004-09-15 00:00:00

  • Prolonged-release fampridine treatment improved subject-reported impact of multiple sclerosis: Item-level analysis of the MSIS-29.

    abstract：:Prolonged-release (PR) fampridine is approved to treat walking impairment in persons with multiple sclerosis (MS); however, treatment benefits may extend beyond walking. MOBILE was a phase 2, 24-week, double-blind, placebo-controlled exploratory study to assess the impact of 10mg PR-fampridine twice daily versus place...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jns.2016.08.052

    authors： Gasperini C,Hupperts R,Lycke J,Short C,McNeill M,Zhong J,Mehta LR

    更新日期：2016-11-15 00:00:00

  • Low-level EMFs are transduced like other stimuli.

    abstract：:The aims of this study were to test the theory that transduction of low-level electromagnetic fields (EMFs) is mediated like other stimuli, and to determine the false-negative rate of the method used to assess the occurrence of transduction (intra-subject comparison of stimulus and non-stimulus states (ICOS)). A light...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)00188-8

    authors： Marino AA,Bell GB,Chesson A

    更新日期：1996-12-01 00:00:00

  • Potassium channel antibody-associated encephalitis with hypothalamic lesions and intestinal pseudo-obstruction.

    abstract：:A subgroup of limbic encephalitis is associated with antibodies against voltage-gated potassium channels (VGKC), and responds well to immuno-modulating therapies. Anti-VGKC antibodies are also found in Isaacs' syndrome and Morvan's syndrome, both of which are sometimes complicated by thymoma. We describe a 52-years-ol...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.12.019

    authors： Sekiguchi Y,Takahashi H,Mori M,Ito S,Shimada H,Hattori T,Kuwabara S

    更新日期：2008-06-15 00:00:00

  • Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS.

    abstract：:Recently, TAR DNA-binding protein of 43-kDa (TDP-43) was identified as a major component of ubiquitinated neuronal cytoplasmic inclusions observed in lower motor neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions. We herein investigated the relationship b...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.12.016

    authors： Fujita Y,Mizuno Y,Takatama M,Okamoto K

    更新日期：2008-06-15 00:00:00

  • Ubiquitin-positive inclusion in anterior horn cells in subgroups of motor neuron diseases: a comparative study of adult-onset amyotrophic lateral sclerosis, juvenile amyotrophic lateral sclerosis and Werdnig-Hoffmann disease.

    abstract：:This report concerns the expression of ubiquitin in anterior horn cells of various subgroups of adult and infantile motor neuron disease (MNDs); immunohistochemical techniques were employed. Ubiquitin-positive skein-like inclusions (SLIs) were found in all cases of adult-onset amyotrophic lateral sclerosis (ALS), incl...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90226-o

    authors： Matsumoto S,Goto S,Kusaka H,Imai T,Murakami N,Hashizume Y,Okazaki H,Hirano A

    更新日期：1993-04-01 00:00:00

  • Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia.

    abstract：OBJECT:The purpose of this study was to determine the effects of diazoxide on apoptosis and the relative mechanisms in a model of brain injury induced by cerebral ischemia/reperfusion (I/R) during deep hypothermia. METHODS:Three-week-old Sprague-Dawley male rats were randomly and equitably divided into sham-operated g...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2007.10.029

    authors： He X,Mo X,Gu H,Chen F,Gu Q,Peng W,Qi J,Shen L,Sun J,Zhang R,Kj Y

    更新日期：2008-05-15 00:00:00

  • A unique episode of REM sleep behavior disorder triggered during surgery for Parkinson's disease.

    abstract：:REM sleep behavior disorder (RBD) is characterized by vigorous movements during REM sleep. Here, the authors report the case of a patient who presented such a disorder immediately after the implantation of the definitive electrode for left subthalamic stimulation. Interestingly, this was and has remained a unique epis...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.11.005

    authors： Piette T,Mescola P,Uytdenhoef P,Henriet M,Vanderkelen B,Jacquy J,Seeldrayers P,Godaux E

    更新日期：2007-02-15 00:00:00

  • An unusual late complication of intracerebral haematoma in herpes encephalitis after successful acyclovir treatment.

    abstract：:This is a case report of PCR proven herpes simplex (HSV-1) encephalitis in a 26 years old immunocompetent adult taking an unusual course of acute intracerebral haematoma after successful and complete recovery with acyclovir therapy. This transient late complication was associated with a negative repeat CSF PCR for HSV...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2006.10.020

    authors： Shelley BP,Raniga SB,Al-Khabouri J

    更新日期：2007-01-31 00:00:00

  • Parabiotic reinnervation in normal and dystrophic mice. Part 2. Morphological studies.

    abstract：:The technique of parabiotic reinnervation has been used to test directly the neurogenic theory of the aetiology of muscular dystrophy in mice. Dystrophic muscles contain significantly fewer muscle fibres than their normal controls; they also have a much broader spectrum of fibre size because of a much higher proportio...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(75)90212-9

    authors： Johnson MA,Montgomery A

    更新日期：1975-11-01 00:00:00

  • CSF analysis of IgH gene rearrangement in CNS lymphoma: relationship to the disease course.

    abstract：PURPOSE:To assess whether clonal IgH genes in CSF of patients with CNS lymphoma correlates with the disease course. BACKGROUND:It has been shown that the PCR technique, which offers a sensitive test for diagnosis of systemic lymphoproliferative malignancies, can be applied to the CSF. METHODS:Seventy-three CSF specim...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.03.012

    authors： Ekstein D,Ben-Yehuda D,Slyusarevsky E,Lossos A,Linetsky E,Siegal T

    更新日期：2006-08-15 00:00:00

  • Novel mutations in the sacsin gene in ataxia patients from Maritime Canada.

    abstract：:We ascertained two families in Eastern Canada segregating a form of ataxia consistent with a recessive mode of inheritance. We performed a whole genome scan using dense SNP genotyping, and despite an absence of shared homozygosity in the families we defined linkage to a small region on chromosome 13. Direct DNA resequ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.09.034

    authors： Guernsey DL,Dubé MP,Jiang H,Asselin G,Blowers S,Evans S,Ferguson M,Macgillivray C,Matsuoka M,Nightingale M,Rideout A,Delatycki M,Orr A,Ludman M,Dooley J,Riddell C,Samuels ME

    更新日期：2010-01-15 00:00:00

  • The lack of deep reflexes in myotonic dystrophy.

    abstract：:Clinical and electrophysiological observations have been carried out on 12 patients with myotonic dystrophy. Neurological examination showed that the tendon reflexes were absent or weak in almost all cases, whereas the cutaneous reflexes were normal. Examination of both deep and superficial sensibility gave normal res...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(76)90136-2

    authors： Messina C,Tonali P,Scoppetta C

    更新日期：1976-12-01 00:00:00

  • Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients.

    abstract：BACKGROUND:Hypertensive (HT) patients are at higher risk of cognitive decline than normotensive individuals, because high blood pressure is a risk factor for mild cognitive deterioration. In this study cardio- and cerebrovascular reactivity along with cognitive performance was assessed on newly diagnosed HT patients. ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.07.022

    authors： Kovács KR,Szekeres CC,Bajkó Z,Csapó K,Molnár S,Oláh L,Magyar MT,Bereczki D,Kardos L,Soltész P,Bojtor AB,Csiba L

    更新日期：2010-12-15 00:00:00

  • Trends in epilepsy diagnosis and surgery in western China during 2009-2017.

    abstract：OBJECTIVE:Despite the strong evidence for the efficacy of surgery to treat temporal lobe epilepsy, the number of such surgeries has plateaued in western countries. This study examined trends in the number of epilepsy cases diagnosed, number of surgeries performed, and certain characteristics of surgery patients in west...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.06.026

    authors： Qiu X,Lai W,Kinoshita M,Zhang L,Li H,Peng A,Li W,Chen L

    更新日期：2019-08-15 00:00:00

  • Olfactory dysfunction in patients with multiple sclerosis.

    abstract：:Association of changes in olfactory-related structures with olfactory function in patients with multiple sclerosis (MS) is not well understood. We used a T&T olfactometer test kit to evaluate olfactory function in 26 patients with MS and 26 age- and sex-matched healthy controls (HC). Then, Brain MRI were performed and...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.03.045

    authors： Li LM,Yang LN,Zhang LJ,Fu Y,Li T,Qi Y,Wang J,Zhang DQ,Zhang N,Liu J,Yang L

    更新日期：2016-06-15 00:00:00

  • Cerebellar peduncular myelinolysis in a patient receiving hemodialysis.

    abstract：:Here, we report the observation of extrapontine lesions, in addition to the pontine lesions previously documented in a diagnosed case of hemodialysis-associated osmotic demyelination syndrome due to end-stage renal disease. The patient exhibited lesions on bilateral middle cerebellar peduncles, and had been receiving ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.10.012

    authors： Kim J,Song T,Park S,Choi IS

    更新日期：2007-02-15 00:00:00