Effects of smoking on outcomes after acute atherothrombotic stroke in Japanese men.

Abstract:

BACKGROUND:The effects of smoking on clinical outcomes following acute stroke remain controversial. METHODS:We evaluated the influence of smoking on 90-day outcomes after acute atherothrombotic stroke in 292 Japanese men extracted from the database of the Edaravone and Argatroban Stroke Therapy for Acute Ischemic Stroke randomized parallel-group trial that tested the safety and efficacy of edaravone and argatroban therapy in 814 patients in 2004-2008. Smokers were matched with non-smokers of the same age for identical age distribution in the smoker and non-smoker groups. Poor 90-day outcomes (defined as death, Barthel index<60, or modified Rankin score>3) were evaluated using a logistic regression model. Significant variables (P<0.05) in univariate analysis were further evaluated by multivariate logistic regression analysis using a forward-selection method. RESULTS:Body temperature, age, National Institute of Health Stroke Scale score at admission, systolic blood pressure, and smoking status were selected in the final model. Smokers had significantly increased odds of poor 90-day functional outcomes independent of other statistically significant predictor variables (adjusted odds ratio, 2.28; 95% confidence interval, 1.15-4.55; P=0.019). CONCLUSIONS:In Japanese men, smoking leads to poor functional outcomes at 3 months after acute atherothrombotic stroke.

journal_name

J Neurol Sci

authors

Kumagai N,Okuhara Y,Iiyama T,Fujimoto Y,Takekawa H,Origasa H,Kawanishi Y,Yamaguchi T

doi

10.1016/j.jns.2013.09.023

subject

Has Abstract

pub_date

2013-12-15 00:00:00

pages

164-8

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(13)02932-8

journal_volume

335

pub_type

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