当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.

Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.

Abstract：

:We evaluated the efficacy of low-dose, add-on therapy of CLB in adults with refractory epilepsy. 28 patients were included: 12 with temporal lobe epilepsy (TLE), 14 with extratemporal lobe epilepsy (ETLE) and 2 with symptomatic generalized epilepsy (SGE). CLB was added with the initial dose of 2.5 mg/day and increased to the optimal dose (mean, 5.6 mg/day). The mean observation period was 7.9 months. As compared with the baseline period, 14 out of 28 patients (50%) obtained an obviously good seizure control: 6 seizure free and 8 more than 50% of seizure reduction. The 14 patients comprised of 4 TLE, 8 ETLE and 2 SGE. In seizure type analysis, 26% of complex partial seizures (CPS), 64% of simple partial seizures (SPS) and 86% of generalized tonic-clonic seizures (GTC) showed a good control. Blood level of N-desmethyl-CLB in the steady state was higher in seizure-free group of 6 patients, and N-desmethyl-CLB blood level/dose per kg body weight correlated significantly to seizure control (p=0.0167). Our data show that even in low dose CLB was effective to patients with refractory epilepsy who had higher blood level of N-desmethyl-CLB.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Kinoshita M,Ikeda A,Begum T,Terada K,Shibasaki H

doi

10.1016/j.jns.2007.05.025

subject

Has Abstract

pub_date

2007-12-15 00:00:00

pages

44-8

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(07)00384-X

journal_volume

263

pub_type

临床试验,杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy.

    abstract：:Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disorder of muscle in children. The DMD gene product, "dystrophin", is absent from DMD, while the allelic disease, Becker muscular dystrophy (BMD), exhibits dystrophin of abnormal size and/or quantity. But we are still uncertain about the scenario that in...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90039-a

    authors： Arahata K,Beggs AH,Honda H,Ito S,Ishiura S,Tsukahara T,Ishiguro T,Eguchi C,Orimo S,Arikawa E

    更新日期：1991-02-01 00:00:00

  • The effects of glycerol on cerebral ultrastructure following experimentally induced cerebral ischemia.

    abstract：:Ultrastructural changes in cerebral tissue subjected to temporary occlusion on the right middle cerebral artery for intervals of 30 min, 1, 2, 3, and 4 hr were studied after daily injections of 10% glycerol in saline. These changes were compared with previously reported data from untreated animals. The extent of tiss...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(75)90035-0

    authors： Dodson RF,Tagashira Y,Wai-Fong Chu L

    更新日期：1975-10-01 00:00:00

  • Serum antibodies against cytosol antigens in multiple sclerosis.

    abstract：:Immunologically pure IgG was isolated from serum of multiple sclerosis (MS) patients and normal controls. The F(ab)2 moiety of IgG was then isolated by salting out between 12.5 and 19.0% Na2SO4 of the pepsin digest of IgG. The ability of the 131I-labelled F(ab)2 to bind to subcellular brain fractions (nuclei, synaptos...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(83)90063-1

    authors： Clausen J

    更新日期：1983-08-01 00:00:00

  • Cognitive impairment and hypothymia in post stroke patients.

    abstract：:129 patients aged 18-84 in early rehabilitation period of the first hemispheric ischemic stroke and 48 patients with cerebrovascular disorders without stroke in anamnesis were observed. Cognitive functions (MMSE, FAB, Clock Drawing Test, the 5-Word test, attention assessment, Semantic Verbal Fluency test) and emotiona...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.11.013

    authors： Pustokhanova L,Morozova E

    更新日期：2013-02-15 00:00:00

  • French translation and normation of the Parkinson Neuropsychometric Dementia Assessment (PANDA).

    abstract：INTRODUCTION:Cognitive impairment and depressive symptoms caused by Parkinson's disease (PD) are often underestimated in routine clinical practice, partly due to the lack of short screening tests. The "Parkinson Neuropsychometric Dementia Assessment" (PANDA) is a new convenient tool, validated in German, to assess cogn...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.06.044

    authors： Gasser AI,Kalbe E,Calabrese P,Kessler J,Von Allmen G,Rossier P

    更新日期：2011-11-15 00:00:00

  • Mechanisms of muscular hypertrophy.

    abstract：:The effects of synergist tenotomy have been studied on rat soleus muscles after denervation and after interference with sciatic axoplasmic flow with colchicine. The results suggest that neural, as well as muscular, factors cause compensatory hypertrophy (CH) of soleus. The myogenic factor may be mild depolarization of...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90166-5

    authors： Hofmann WW

    更新日期：1980-03-01 00:00:00

  • Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis.

    abstract：:Multiple sclerosis is an inflammatory disease of the central nervous system (CNS) which includes a neurodegenerative component. Brain derived neurotrophic factor (BDNF) is a neuroprotective agent which might be useful in preventing neurodegeneration but its application has been limited because the blood brain barrier ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.02.011

    authors： Makar TK,Trisler D,Sura KT,Sultana S,Patel N,Bever CT

    更新日期：2008-07-15 00:00:00

  • Are white matter abnormalities associated with "unexplained dizziness"?

    abstract：INTRODUCTION:Although cerebral small vessel disease is a significant contributor to the development of imbalance and falls in the elderly, whether it causes dizziness is not known. METHODS:A retrospective case analysis was conducted for 122 dizzy patients referred to two neuro-otology tertiary centres in London and Pi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2015.09.006

    authors： Ahmad H,Cerchiai N,Mancuso M,Casani AP,Bronstein AM

    更新日期：2015-11-15 00:00:00

  • Serum cortisol and outcome of ischemic brain infarction.

    abstract：:The predictive value of serum cortisol level on the prognosis in acute brain infarction of the carotid circulation territory was studied in 101 patients younger than 70 years. The levels of 7 a.m. and 7 p.m. serum cortisol were measured initially and at 1 week. All patients underwent a computed cerebral tomography (CT...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90083-b

    authors： Murros K,Fogelholm R,Kettunen S,Vuorela AL

    更新日期：1993-05-01 00:00:00

  • Functional consequences of the 3460-bp mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.

    abstract：:Complex I is the largest of the mitochondrial respiratory chain proteins, and contains subunits encoded by both mitochondrial and nuclear genomes. Leber's hereditary optic neuropathy has been clearly linked to mutations of mitochondrial DNA complex I genes, and variable complex I functional defects have been reported....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00088-x

    authors： Cock HR,Cooper JM,Schapira AH

    更新日期：1999-05-01 00:00:00

  • The effects of bilateral subthalamic nucleus deep brain stimulation (STN DBS) on cognition in Parkinson disease.

    abstract：:The effects of subthalamic nucleus (STN) stimulation on cognition and mood have not been well established. The authors estimated cognitive and mood effects of bilateral subthalamic nucleus deep brain stimulation (STN DBS) in patients with Parkinson's disease (PD) at 6 months and 1 year postoperatively. Forty-six patie...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jns.2008.06.010

    authors： Heo JH,Lee KM,Paek SH,Kim MJ,Lee JY,Kim JY,Cho SY,Lim YH,Kim MR,Jeong SY,Jeon BS

    更新日期：2008-10-15 00:00:00

  • Acute endothelial swelling is induced in endoneurial microvessels by ischemia.

    abstract：:Structural alterations of endoneurial microvessels occur in diabetic neuropathy and are statistically associated with severity of nerve fiber loss and teased fiber abnormality. It is therefore hypothesized that the microvessel alterations may cause or contribute to pathologic alterations of nerve fibers in diabetic ne...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90197-u

    authors： Benstead TJ,Sangalang VE,Dyck PJ

    更新日期：1990-10-01 00:00:00

  • Analysis of the major lipid classes in human peripheral nerve biopsies. Age group differences and abnormalities of ganglioside level in perhexiline maleate therapy.

    abstract：:We report here the results of a simple and reproducible technique which can be used in semi-routine analysis of peripheral nerve biopsy specimens, so as to have a quantitative analysis of the major lipid classes, i.e. cholesterol, cerebrosides, ethanolamine phospholipids, phosphatidyl-choline, phosphatidyl-serine + ph...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90039-x

    authors： Pollet S,Hauw JJ,Turpin JC,Le Saux F,Escourolle R,Baumann N

    更新日期：1979-04-01 00:00:00

  • Does education modify motor compensation in Parkinson's disease?

    abstract：BACKGROUND:In Alzheimer's disease, higher educational attainment is associated with fewer cognitive deficits despite similar pathological lesions. In animal models of Parkinson's disease (PD), enhanced levels of cognitive and physical stimulation can reduce motor deficits due to dopaminergic neuronal loss. Therefore, i...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.01.030

    authors： Sunwoo MK,Hong JY,Lee JJ,Lee PH,Sohn YH

    更新日期：2016-03-15 00:00:00

  • Acute ischaemic neuropathy in the rabbit.

    abstract：:Ligation of either the common and internal iliac or the internal and external iliac arteries produced ischaemic lesions of the sciatic nerve and its branches, as well as direct muscle damage, in 5 out of 6 rabbits. In one animal, ligation of the aorta and of the internal iliac artery on one side produced a similar mix...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90220-x

    authors： Hess K,Eames RA,Darveniza P,Gilliatt RW

    更新日期：1979-12-01 00:00:00

  • Brainstem gliomas--retrospective analysis of 86 patients.

    abstract：:Brainstem gliomas constitute 10% of brain tumors in children and less than 2% in adults. Since therapeutic options are limited and brainstem gliomas are associated with a high morbidity and mortality, we sought to analyze the prognostic factors associated with a better outcome. We reviewed the records of 86 patients w...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.03.009

    authors： Ueoka DI,Nogueira J,Campos JC,Maranhão Filho P,Ferman S,Lima MA

    更新日期：2009-06-15 00:00:00

  • The contribution of magnetic resonance imaging in the differential diagnosis of optic nerve damage.

    abstract：:In this paper we review the findings of magnetic resonance imaging (MRI) in optic neuritis and visual dysfunction due to other optic neuropathies. With advances in MRI technology, it has become possible to visualise optic nerve pathology. STIR and RARE sequences, contrast-enhanced sequences, and phased array surface c...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-510x(99)00272-5

    authors： Gass A,Moseley IF

    更新日期：2000-01-15 00:00:00

  • A case of chronic demyelinating polyneuropathy resembling the Guillain-Barré syndrome.

    abstract：:A case of demyelinating polyneuropathy is reported which was clinically and pathologically indistinguishable from the Guillain-Barré syndrome, with the exception that the symptoms progressed steadily for 7 months. Pathologically, the peripheral nerves and intraspinal roots showed selective demyelination with axonal sp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(77)90038-7

    authors： Torvik A,Lundar T

    更新日期：1977-05-01 00:00:00

  • Diffusion-weighted imaging in Wallerian degeneration.

    abstract：:We report two patients displaying hyperintensities on diffusion-weighted imaging (DWI) in the area of Wallerian degeneration (WD) at 12 days after stroke. High signal intensities were more conspicuous on DWI than on T2-weighted images. Both patients showed decreased diffusion anisotropy resulting in elevated apparent ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(00)00373-7

    authors： Kang DW,Chu K,Yoon BW,Song IC,Chang KH,Roh JK

    更新日期：2000-09-15 00:00:00

  • Childhood cow's milk allergy and the risk of multiple sclerosis: a population based study.

    abstract：:Autoimmune mechanisms are thought to have a major role in the pathogenesis of multiple sclerosis (MS) and vitamin D is hypothesised to contribute to disease susceptibility. Cow's milk allergy (CMA) is a common childhood allergy arising from an immune system imbalance and can also lead to vitamin D deficiency due to da...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.10.021

    authors： Ramagopalan SV,Dyment DA,Guimond C,Orton SM,Yee IM,Ebers GC,Sadovnick AD

    更新日期：2010-04-15 00:00:00

  • Progressive aphemia in a patient with Pick's disease: a neuropsychological and anatomic study.

    abstract：:We describe a patient with progressive aphemia with agrammatism that was later overlaid with buccofacial apraxia and pseudobulbar palsy. Pathological findings were consistent with those of classic Pick's disease with argyrophilic inclusions and neuronal achromasia, except for restricted cortical atrophy in the frontal...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(98)00159-2

    authors： Sakurai Y,Murayama S,Fukusako Y,Bando M,Iwata M,Inoue K

    更新日期：1998-08-14 00:00:00

  • Clinically relevant cognitive impairment after cardiac surgery: a 6-month follow-up study.

    abstract：BACKGROUND AND PURPOSE:The majority of studies on neuropsychological complications after cardiac surgery used the raw variation of selective tests scores to define the occurrence of cognitive decline. We prospectively estimated the frequency of cognitive impairment after cardiac surgery, with a particular emphasis on p...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00554-8

    authors： Di Carlo A,Perna AM,Pantoni L,Basile AM,Bonacchi M,Pracucci G,Trefoloni G,Bracco L,Sangiovanni V,Piccini C,Palmarini MF,Carbonetto F,Biondi E,Sani G,Inzitari D

    更新日期：2001-07-15 00:00:00

  • Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age.

    abstract：:The frequency of senile plaques and neurofibrillary tangles and the number of pyramidal neurones and the volume of their nucleolus were measured in temporal cortex (middle temporal gyrus) and hippocampus (area h1) of 32 patients with Alzheimer's disease. Plaques and tangles were greatly increased in frequency in these...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(85)90129-7

    authors： Mann DM,Yates PO,Marcyniuk B

    更新日期：1985-07-01 00:00:00

  • Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

    abstract：:HS1-associated protein X-1 (HAX-1) and presenilin-associated rhomboid-like protein (PALR) were reported to play an important role in the activation of HtrA2/Omi, which is also designated PARK13, in the mitochondria. To elucidate the role of HAX-1 and PARL in patients with Parkinson's disease (PD) and dementia with Lew...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116928

    authors： Kawamoto Y,Ayaki T,Urushitani M,Ito H,Takahashi R

    更新日期：2020-08-15 00:00:00

  • Insights into thermoregulation: a clinico-radiological description of Shapiro syndrome.

    abstract：:Shapiro syndrome is a rare entity, comprising a triad of recurrent hypothermia, hyperhidrosis and congenital agenesis of the corpus callosum. Fewer than 50 cases have been described, almost invariably in patients presenting in childhood or early adulthood. We present a case of an 80 year old woman presenting with recu...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.03.014

    authors： Pazderska A,O'Connell M,Pender N,Gavin C,Murray B,O'Dowd S

    更新日期：2013-06-15 00:00:00

  • High resolution retinal scanning reveals regional structural differences between MS and NMOSD optic neuritis regardless of antibody status.

    abstract：BACKGROUND:There is a need for biomarkers that can classify optic neuritis (ON) attacks as belonging to either neuromyelitis optica spectrum disorder with optic neuritis (NMOSD-ON) or relapsing remitting multiple sclerosis with optic neuritis (MS-ON). This study uses spectral domain optical coherence tomography (SD-OCT...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.11.017

    authors： Bertsch-Gout M,Loeb R,Finch AK,Javed A,Bernard J

    更新日期：2018-01-15 00:00:00

  • The pattern of E2F1 and c-myb immunoreactivities in the CA1 region is different from those in the CA2/3 region of the gerbil hippocampus induced by transient ischemia.

    abstract：:In this study, we examined transient ischemia-induced changes in transcription factor E2F1 and c-myb expressions in the gerbil hippocampus after 5 min of transient forebrain ischemia. E2F1 immunoreactivity significantly increased in the CA1 region 6-12 h after ischemia/reperfusion. c-myb immunoreactivity increased mai...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.05.048

    authors： Hwang IK,Yoo KY,Cho BM,Hwang HS,Kim SM,Oh SM,Choi SK,Hwang DY,Won MH,Moon SM

    更新日期：2006-09-25 00:00:00

  • A protective effect of early pregnancy factor on experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein.

    abstract：:Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease characterised by inflammation and demyelination of the central nervous system and is the best available animal model of multiple sclerosis (MS). Since previous studies have shown that EAE is less severe or is delayed in onset durin...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(03)00212-0

    authors： Harness J,Cavanagh A,Morton H,McCombe P

    更新日期：2003-12-15 00:00:00

  • SPG2 mimicking multiple sclerosis in a family identified using next generation sequencing.

    abstract：:Several single gene disorders can potentially be overlooked in the differential diagnostic evaluation of patients with multiple sclerosis (MS). Pelizaeus-Merzbacher disease and spastic paraplegia type 2 are allelic X-linked disorders associated with defective myelination of the central nervous system and mutations in ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.01.069

    authors： Rubegni A,Battisti C,Tessa A,Cerase A,Doccini S,Malandrini A,Santorelli FM,Federico A

    更新日期：2017-04-15 00:00:00

  • Immunohistochemical study of Alzheimer's disease using antibodies to synthetic amyloid and fibronectin.

    abstract：:Etiology and source of amyloid deposition in senile plaques of Alzheimer's disease (AD) are still unknown. In order to know whether or not fibronectin (Fn), an adhesive glycoprotein, is related to the amyloid deposition in the senile plaque, we conducted immunohistochemical studies using polyclonal anti-Fn and affinit...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90031-7

    authors： Koike F,Kunishita T,Nakayama H,Tabira T

    更新日期：1988-05-01 00:00:00